phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Canals D et al. Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. 2009 Bioorg. Med. Chem. pmid:19056278
Hoeller S et al. Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. 2009 Int J Pharm pmid:19073240
Videira A et al. Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function. 2009 Microbiology (Reading, Engl.) pmid:19520721
Hancock SM et al. Designer enzymes for glycosphingolipid synthesis by directed evolution. 2009 Nat. Chem. Biol. pmid:19525967
Mitsui K et al. Saccharomyces cerevisiae Na+/H+ antiporter Nha1p associates with lipid rafts and requires sphingolipid for stable localization to the plasma membrane. 2009 J. Biochem. pmid:19254924
Hill JR and Wertz PW Structures of the ceramides from porcine palatal stratum corneum. 2009 Lipids pmid:19184160
Kim BM et al. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells. 2009 Toxicol. Appl. Pharmacol. pmid:19481559
Rodgers A et al. Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. 2009 Stem Cells Dev. pmid:19228106
Yang F et al. DNA immunization perturbs lipid metabolites and increases risk of atherogenesis. 2008 J. Proteome Res. pmid:18166009
Amemiya F et al. Targeting lipid metabolism in the treatment of hepatitis C virus infection. 2008 J. Infect. Dis. pmid:18248300
Kim S et al. Efficient and selective synthesis of D-arabino-, D-lyxo-, and D-xylo-phytosphingosine from D-ribo-phytosphingosine. 2008 J. Org. Chem. pmid:18197680
Kyogashima M et al. Chemical and apoptotic properties of hydroxy-ceramides containing long-chain bases with unusual alkyl chain lengths. 2008 J. Biochem. pmid:18420598
Hannay K et al. Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. 2008 BMC Genomics pmid:19087332
Castro A et al. Increased resistance of complex I mutants to phytosphingosine-induced programmed cell death. 2008 J. Biol. Chem. pmid:18474589
Garcia J et al. Mathematical modeling of pathogenicity of Cryptococcus neoformans. 2008 Mol. Syst. Biol. pmid:18414484
Itonori S et al. Structural characterization of glycosylinositolphospholipids with a blood group type B sugar unit from the edible mushroom, Hypsizygus marmoreus. 2008 Glycobiology pmid:18450973
Shang P et al. Chemical modification of iGb3 increases IFN-gamma production by hepatic NKT cells. 2008 Int. Immunopharmacol. pmid:18387506
Worrall D et al. Involvement of sphingosine kinase in plant cell signalling. 2008 Plant J. pmid:18557834
Pruett ST et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. 2008 J. Lipid Res. pmid:18499644
Thevissen K et al. Fungicidal activity of truncated analogues of dihydrosphingosine. 2008 Bioorg. Med. Chem. Lett. pmid:18524581