phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Wright BS et al. Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn. 2003 Arch. Biochem. Biophys. pmid:12831841
Cheng J et al. Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. 2003 Mol. Cell. Biol. pmid:12482970
Ponec M et al. New acylceramide in native and reconstructed epidermis. 2003 J. Invest. Dermatol. pmid:12648220
Kim HJ et al. Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis. 2003 J. Invest. Dermatol. pmid:14708615
Kim HJ et al. Tetraacetyl phytosphingosine-induced caspase activation and apoptosis occur through G2 arrest in human keratinocyte HaCaT cells. 2003 J. Invest. Dermatol. pmid:14708616
Kim HJ et al. Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells. 2003 Mol. Cells pmid:14744023
Seefelder W et al. Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. 2003 Toxicol. Appl. Pharmacol. pmid:14550748
Park MT et al. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. 2003 J. Biol. Chem. pmid:14522966
Kariotoglou DM and Mastronicolis SK Sphingophosphonolipid molecular species from edible mollusks and a jellyfish. 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12941637
Ardail D et al. The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases. 2003 Biochem. J. pmid:12578562