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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
2017 |
Blood |
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A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. |
2017 |
Inflamm. Res. |
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Williams PA et al. |
Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. |
2017 |
Ann Biomed Eng |
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The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. |
2017 |
Clin. Immunol. |
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S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. |
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J. Lipid Res. |
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High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:27879252
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Barnawi J et al. |
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
2017 |
Respirology |
pmid:27868302
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High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. |
2017 |
Eur. J. Clin. Invest. |
pmid:27861771
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Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
2017 |
Nat. Immunol. |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
2017 |
Am. J. Pathol. |
pmid:27840081
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
pmid:27727447
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Åukomska A et al. |
The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
2017 |
Chemosphere |
pmid:27697711
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Sánchez DI et al. |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
2017 |
J. Pineal Res. |
pmid:27696512
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Lim J et al. |
Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. |
2017 |
Int. J. Mol. Med. |
pmid:28677769
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Mitroi DN et al. |
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. |
2017 |
Autophagy |
pmid:28521611
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Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
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Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
2017 |
Mol. Neurobiol. |
pmid:27631876
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Hajny S and Christoffersen C |
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
pmid:28749426
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Bertlich M et al. |
Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
2017 |
Otol. Neurotol. |
pmid:28742634
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Koch A et al. |
Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
2017 |
Int J Mol Sci |
pmid:28714882
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Wilkerson JL and Mandal NA |
Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. |
2017 |
Methods Mol. Biol. |
pmid:28660590
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Kurano M et al. |
Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. |
2017 |
PLoS ONE |
pmid:28494002
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Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. |
2017 |
Thromb. Res. |
pmid:28609704
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Azimzadeh K et al. |
Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
2017 |
Microb. Pathog. |
pmid:28533142
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Oh YT et al. |
DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
2017 |
Cell Commun. Signal |
pmid:28482915
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Fan Q et al. |
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. |
2017 |
Oncotarget |
pmid:28460443
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The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. |
2017 |
J. Lipid Res. |
pmid:28588048
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
2017 |
Adv Biol Regul |
pmid:27720306
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Al-Jarallah A and Oriowo M |
The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
2017 |
PLoS ONE |
pmid:28493876
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Fang R et al. |
Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. |
2017 |
Arch. Med. Res. |
pmid:28625317
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. |
2017 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:28618839
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Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. |
2017 |
J. Immunol. |
pmid:28600291
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High-Density Lipoprotein Regulation of Mitochondrial Function. |
2017 |
Adv. Exp. Med. Biol. |
pmid:28551800
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Dany M and Elston D |
Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. |
2017 |
J. Am. Acad. Dermatol. |
pmid:28551069
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Mendoza A et al. |
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. |
2017 |
Nature |
pmid:28538737
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Ma S et al. |
A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |
2017 |
Dev. Cell |
pmid:28535372
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Meshcheryakova A et al. |
Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. |
2017 |
Expert Opin. Ther. Targets |
pmid:28524744
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Ko J et al. |
Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
pmid:28492873
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Aoyama-Araki Y et al. |
Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
pmid:28418499
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Lee HM et al. |
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. |
2017 |
J. Pathol. |
pmid:28240350
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Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. |
2017 |
Eur. J. Immunol. |
pmid:28198542
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Bruno M et al. |
Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. |
2017 |
Biochim. Biophys. Acta |
pmid:28188805
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Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. |
2017 |
J. Lipid Res. |
pmid:28188148
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Ren K et al. |
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. |
2017 |
J. Physiol. Biochem. |
pmid:28181168
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Ruiz M et al. |
HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. |
2017 |
Lipids Health Dis |
pmid:28179022
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Moruno-Manchon JF et al. |
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
2017 |
Hum. Mol. Genet. |
pmid:28175299
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Rojas-Canales D et al. |
Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
2017 |
Diabetes |
pmid:28174291
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Dela Paz NG et al. |
Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. |
2017 |
Am. J. Physiol., Cell Physiol. |
pmid:28148497
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Green CL et al. |
The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
2017 |
Aging Cell |
pmid:28139067
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Vishwakarma S et al. |
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
2017 |
Cancer Invest. |
pmid:28135860
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