| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Fabry Disease | D000795 | 4 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Roviezzo F et al. | Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. | 2014 | Clin. Sci. | pmid:24131465 |
| Qin Z et al. | Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. | 2014 | Mol. Cancer Ther. | pmid:24140934 |
| Ryu JM et al. | Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. | 2014 | Stem Cell Res | pmid:24145189 |
| Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
| Purschke WG et al. | Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. | 2014 | Biochem. J. | pmid:24832383 |
| Karaca I et al. | Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. | 2014 | J. Biol. Chem. | pmid:24808180 |
| Fayyaz S et al. | Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. | 2014 | Diabetologia | pmid:24292566 |
| Meng Y et al. | Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. | 2014 | Fertil. Steril. | pmid:24993801 |
| Kang JW and Lee SM | Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24997335 |
| Langeslag M et al. | Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. | 2014 | Mol Pain | pmid:25431213 |
| Callihan P et al. | Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. | 2014 | ASN Neuro | pmid:25424429 |
| Kułakowska A et al. | Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. | 2014 | J Neuroinflammation | pmid:25421616 |
| Gomes L et al. | Sphingosine 1-phosphate in acute dengue infection. | 2014 | PLoS ONE | pmid:25409037 |
| Hamidi S et al. | TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. | 2014 | Biochim. Biophys. Acta | pmid:24440818 |
| Park K et al. | The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. | 2014 | J. Nutr. Biochem. | pmid:24768661 |
| Schaper K et al. | Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. | 2014 | Mol. Immunol. | pmid:24434636 |
| Kono M et al. | Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. | 2014 | J. Clin. Invest. | pmid:24667638 |
| Sasaki H et al. | Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. | 2014 | Arch. Biochem. Biophys. | pmid:24708996 |
| Ntranos A et al. | FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. | 2014 | J. Neuroimmunol. | pmid:24680062 |
| Liu M et al. | Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. | 2014 | J. Biol. Chem. | pmid:24318881 |
| Li F et al. | Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. | 2014 | Hum. Reprod. | pmid:24221908 |
| Hirata N et al. | Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. | 2014 | Nat Commun | pmid:25254944 |
| Bigaud M et al. | Second generation S1P pathway modulators: research strategies and clinical developments. | 2014 | Biochim. Biophys. Acta | pmid:24239768 |
| Iino J et al. | Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. | 2014 | Lipids Health Dis | pmid:25253303 |
| Xiong Y et al. | Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. | 2014 | J. Clin. Invest. | pmid:25250575 |
| Tan SJ et al. | Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. | 2014 | Reprod. Biomed. Online | pmid:25246113 |
| Goñi FM et al. | Biophysical properties of sphingosine, ceramides and other simple sphingolipids. | 2014 | Biochem. Soc. Trans. | pmid:25233422 |
| Moon MH et al. | Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes. | 2014 | Int. J. Mol. Med. | pmid:25050633 |
| Wakashima T et al. | Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. | 2014 | J. Biol. Chem. | pmid:25049234 |
| Marfia G et al. | Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. | 2014 | Glia | pmid:25042636 |
| Fuerst E et al. | Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. | 2014 | Allergy | pmid:25041788 |
| Tong X et al. | The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. | 2014 | Cardiovasc Diabetol | pmid:24751283 |
| Murakami M et al. | Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. | 2014 | Acta Biomater | pmid:25038462 |
| Park SJ et al. | Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. | 2014 | Cell. Signal. | pmid:25035231 |
| Kim EY et al. | Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. | 2014 | FASEB J. | pmid:25002116 |
| Ceglarek U et al. | Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. | 2014 | Clin. Chim. Acta | pmid:24768784 |
| Brizuela L et al. | Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. | 2014 | Mol Oncol | pmid:24768038 |
| Poitevin S et al. | Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. | 2014 | Cardiovasc. Res. | pmid:24743591 |
| O'Sullivan MJ et al. | Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. | 2014 | PLoS ONE | pmid:24743449 |
| Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
| Zhu Y et al. | Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. | 2014 | Mol. Neurobiol. | pmid:24722820 |
| Kerage D et al. | Review: novel insights into the regulation of vascular tone by sphingosine 1-phosphate. | 2014 | Placenta | pmid:24411702 |
| Gil-Ortega M et al. | Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations. | 2014 | Int J Obes (Lond) | pmid:24357852 |
| Maeda Y et al. | S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. | 2014 | Int. Immunol. | pmid:24343820 |
| Guo L et al. | Roles of sphingosine-1-phosphate in reproduction. | 2014 | Reprod Sci | pmid:24336672 |
| Shen Z et al. | Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). | 2014 | Cell Stress Chaperones | pmid:24293320 |
| Chen JJ et al. | Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. | 2014 | Steroids | pmid:24269742 |
| Nishi T et al. | Molecular and physiological functions of sphingosine 1-phosphate transporters. | 2014 | Biochim. Biophys. Acta | pmid:23921254 |
| Xia JY et al. | The adipokine/ceramide axis: key aspects of insulin sensitization. | 2014 | Biochimie | pmid:23969158 |
| Albinet V et al. | Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. | 2014 | Oncogene | pmid:23893239 |