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Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
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Tsuchida J et al. |
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
2016 |
J. Surg. Res. |
pmid:27621003
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Targeting sphingosine-1-phosphate signaling in lung diseases. |
2016 |
Pharmacol. Ther. |
pmid:27621206
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Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. |
2016 |
J. Biol. Chem. |
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Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
pmid:27631876
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Custódio R et al. |
Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. |
2016 |
Mol. Microbiol. |
pmid:27632710
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Kemppainen K et al. |
Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. |
2016 |
Cell. Signal. |
pmid:27634386
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Lepannetier S et al. |
Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
2016 |
Cell Calcium |
pmid:27638096
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Scotti L et al. |
Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
2016 |
Mol. Hum. Reprod. |
pmid:27645281
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Kobayashi N et al. |
Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. |
2016 |
J. Lipid Res. |
pmid:27655910
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To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. |
2016 |
Pharmacol. Res. |
pmid:27663260
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Hemdan NY et al. |
Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
2016 |
Eur. J. Immunol. |
pmid:27683081
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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. |
2016 |
Cardiovasc. Res. |
pmid:27694435
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Morillon YM et al. |
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. |
2016 |
J. Immunol. |
pmid:27694496
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Sánchez DI et al. |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
2017 |
J. Pineal Res. |
pmid:27696512
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Åukomska A et al. |
The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
2017 |
Chemosphere |
pmid:27697711
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Beider K et al. |
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
pmid:27697999
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Adamiak M et al. |
The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. |
2016 |
Stem Cell Rev |
pmid:27704316
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Wang X et al. |
Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. |
2016 |
PLoS Pathog. |
pmid:27711202
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Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. |
2016 |
Pharmacol. Res. |
pmid:27713021
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Ebenezer DL et al. |
Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
2017 |
Adv Biol Regul |
pmid:27720306
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Pal SK et al. |
A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
pmid:27727447
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Abraham C et al. |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
pmid:27780712
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
pmid:27784725
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González-Fernández B et al. |
Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
2017 |
Biofactors |
pmid:27801960
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Zhao Z et al. |
Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
2017 |
Acta Haematol. |
pmid:27802432
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Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. |
2016 |
J. Exp. Med. |
pmid:27810923
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Li S et al. |
Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
2016 |
Oncotarget |
pmid:27811358
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Yanagida K and Hla T |
Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
2017 |
Annu. Rev. Physiol. |
pmid:27813829
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Chen T et al. |
Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
pmid:27814635
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Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
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Tan SF et al. |
Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
2016 |
Oncotarget |
pmid:27825124
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O'Sullivan S and Dev KK |
Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
2017 |
Neuropharmacology |
pmid:27825807
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Brait VH et al. |
Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. |
2016 |
Stroke |
pmid:27827329
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Terashita T et al. |
Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. |
2016 |
Respir. Res. |
pmid:27829417
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Trinh HK et al. |
Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. |
2016 |
Sci Rep |
pmid:27830727
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Wang R et al. |
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
2017 |
Am. J. Pathol. |
pmid:27840081
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Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
2017 |
Nat. Immunol. |
pmid:27841869
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Frias MA et al. |
High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. |
2017 |
Eur. J. Clin. Invest. |
pmid:27861771
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Fu P et al. |
Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. |
2016 |
J. Biol. Chem. |
pmid:27864331
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Barnawi J et al. |
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
2017 |
Respirology |
pmid:27868302
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Ruiz M et al. |
High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:27879252
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Lee MH et al. |
S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. |
2017 |
J. Lipid Res. |
pmid:27881715
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Mao-Draayer Y et al. |
The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. |
2017 |
Clin. Immunol. |
pmid:27890706
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Williams PA et al. |
Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. |
2017 |
Ann Biomed Eng |
pmid:27904998
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Winkler MS et al. |
Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
2017 |
Shock |
pmid:27922551
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Miyabe C et al. |
A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. |
2017 |
Inflamm. Res. |
pmid:27942751
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Powell JA et al. |
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
2017 |
Blood |
pmid:27956387
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Soltau I et al. |
Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
2016 |
PLoS ONE |
pmid:27973607
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Surya VN et al. |
Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
2016 |
J R Soc Interface |
pmid:27974574
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