Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

Cross Reference

Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Niemann-Pick Disease, Type C D052556 1 associated lipids
Farber Lipogranulomatosis D055577 1 associated lipids
Tachycardia, Sinus D013616 2 associated lipids
Sensation Disorders D012678 2 associated lipids
Ileus D045823 3 associated lipids
Adenomatous Polyps D018256 4 associated lipids
Fabry Disease D000795 4 associated lipids
Hematologic Neoplasms D019337 4 associated lipids
Shock, Hemorrhagic D012771 4 associated lipids
Ovarian Diseases D010049 5 associated lipids
Dilatation, Pathologic D004108 5 associated lipids
Pregnancy, Ectopic D011271 5 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Teratocarcinoma D018243 7 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Eye Abnormalities D005124 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Thrombocythemia, Essential D013920 9 associated lipids
Cardiomyopathies D009202 10 associated lipids
Retinal Detachment D012163 10 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Influenza, Human D007251 11 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Lung Injury D055370 14 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Vascular Diseases D014652 16 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Anemia D000740 21 associated lipids
Hypersensitivity D006967 22 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Fibrosis D005355 23 associated lipids
Pulmonary Edema D011654 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endotoxemia D019446 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Glioblastoma D005909 27 associated lipids
Neuralgia D009437 28 associated lipids
Insulinoma D007340 28 associated lipids
Proteinuria D011507 30 associated lipids
Acute Lung Injury D055371 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Acne Vulgaris D000152 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Heart Failure D006333 36 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Asthma D001249 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Leukemia D007938 74 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Chimen M et al. Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. 2015 Nat. Med. pmid:25894827
Pulli I et al. A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⁺ microdomain in the caveolar compartment. 2015 Biochim. Biophys. Acta pmid:25892494
Zankov DP and Ogita H Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. 2015 Biomed Res Int pmid:25883953
Zhang DD et al. Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. 2015 Biol. Chem. pmid:25720064
Schröder M et al. Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. 2015 Biol. Chem. pmid:25720062
Koch A et al. Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. 2015 Biol. Chem. pmid:25719311
Roviezzo F et al. S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. 2015 Br. J. Pharmacol. pmid:25439580
Carroll B et al. Sphingolipids in the DNA damage response. 2015 Adv Biol Regul pmid:25434743
Czubowicz K et al. Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival. 2015 Mol. Neurobiol. pmid:25056275
Jeong JK et al. Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. 2015 Mol Med Rep pmid:26459774
Sutter I et al. Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. 2015 Atherosclerosis pmid:26093887
Cantalupo A et al. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. 2015 Nat. Med. pmid:26301690
Adamiak M et al. Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. 2015 Oncotarget pmid:26299919
Chen MH et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. 2015 Oncotarget pmid:26090720
Panneer Selvam S et al. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. 2015 Sci Signal pmid:26082434
El-Najjar N et al. Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. 2015 PLoS ONE pmid:26466367
Rao PV Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. 2014 Mar-Apr J Ocul Pharmacol Ther pmid:24283588
Roviezzo F et al. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. 2014 Clin. Sci. pmid:24131465
Qin Z et al. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. 2014 Mol. Cancer Ther. pmid:24140934
Ryu JM et al. Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. 2014 Stem Cell Res pmid:24145189
Yu Y et al. Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. 2014 Lipids pmid:24158769
Giannouli CC et al. Visualizing S1P-directed cellular egress by intravital imaging. 2014 Biochim. Biophys. Acta pmid:24090699
Zhang Y et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. 2014 J. Clin. Invest. pmid:24837436
Kurano M et al. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. 2014 Biochim. Biophys. Acta pmid:24814049
Brünnert D et al. Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. 2014 Mol. Hum. Reprod. pmid:24994816
Karaca I et al. Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. 2014 J. Biol. Chem. pmid:24808180
Fayyaz S et al. Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. 2014 Diabetologia pmid:24292566
Meng Y et al. Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. 2014 Fertil. Steril. pmid:24993801
Kang JW and Lee SM Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. 2014 Biochem. Biophys. Res. Commun. pmid:24997335
Nagamatsu T et al. Emerging roles for lysophospholipid mediators in pregnancy. 2014 Am. J. Reprod. Immunol. pmid:24689547
Ohotski J et al. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. 2014 Cell. Signal. pmid:24486401
Takeo T et al. Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. 2014 Cryobiology pmid:24201107
de Assuncao TM et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. 2014 J. Biol. Chem. pmid:24759103
Langeslag M et al. Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. 2014 Mol Pain pmid:25431213
Callihan P et al. Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. 2014 ASN Neuro pmid:25424429
Kułakowska A et al. Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. 2014 J Neuroinflammation pmid:25421616
Gomes L et al. Sphingosine 1-phosphate in acute dengue infection. 2014 PLoS ONE pmid:25409037
Xu M et al. FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. 2014 Acta Pharmacol. Sin. pmid:25399649
Watanabe C et al. Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. 2014 Langmuir pmid:25386673
Park K et al. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. 2014 J. Nutr. Biochem. pmid:24768661
Schaper K et al. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. 2014 Mol. Immunol. pmid:24434636
Kono M et al. Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. 2014 J. Clin. Invest. pmid:24667638
Sasaki H et al. Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. 2014 Arch. Biochem. Biophys. pmid:24708996
Ntranos A et al. FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. 2014 J. Neuroimmunol. pmid:24680062
Liu M et al. Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. 2014 J. Biol. Chem. pmid:24318881
Li F et al. Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. 2014 Hum. Reprod. pmid:24221908
Bigaud M et al. Second generation S1P pathway modulators: research strategies and clinical developments. 2014 Biochim. Biophys. Acta pmid:24239768
Iino J et al. Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. 2014 Lipids Health Dis pmid:25253303
Huang YL et al. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. 2014 Cell. Signal. pmid:24333325
Emery SM et al. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. 2014 J. Pharmacol. Exp. Ther. pmid:24259678
Sutter I et al. Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. 2014 J. Lipid Res. pmid:24950692
Adamson RH et al. Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24531813
Xiong Y et al. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. 2014 J. Clin. Invest. pmid:25250575
Rosen H et al. The organization of the sphingosine 1-phosphate signaling system. 2014 Curr. Top. Microbiol. Immunol. pmid:24728591
Tan SJ et al. Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. 2014 Reprod. Biomed. Online pmid:25246113
Hanson MA and Peach R Structural biology of the S1P1 receptor. 2014 Curr. Top. Microbiol. Immunol. pmid:24728592
Goñi FM et al. Biophysical properties of sphingosine, ceramides and other simple sphingolipids. 2014 Biochem. Soc. Trans. pmid:25233422
Yagoub D et al. Sphingosine kinase 1 isoform-specific interactions in breast cancer. 2014 Mol. Endocrinol. pmid:25216046
Yang W et al. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. 2014 PLoS ONE pmid:25188412
Chen J et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. 2014 Am. J. Respir. Crit. Care Med. pmid:25180446
Kong Y et al. Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. 2014 Mediators Inflamm. pmid:25147438
Moon MH et al. Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes. 2014 Int. J. Mol. Med. pmid:25050633
Wakashima T et al. Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. 2014 J. Biol. Chem. pmid:25049234
Marfia G et al. Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. 2014 Glia pmid:25042636
Fuerst E et al. Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. 2014 Allergy pmid:25041788
Tong X et al. The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. 2014 Cardiovasc Diabetol pmid:24751283
Murakami M et al. Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. 2014 Acta Biomater pmid:25038462
Park SJ et al. Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. 2014 Cell. Signal. pmid:25035231
Kim EY et al. Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. 2014 FASEB J. pmid:25002116
Hao J et al. The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. 2014 Arthritis Res. Ther. pmid:25000985
Xiong Y and Hla T S1P control of endothelial integrity. 2014 Curr. Top. Microbiol. Immunol. pmid:24728594
Mendelson K et al. Sphingosine 1-phosphate signalling. 2014 Development pmid:24346695
Rauch BH Sphingosine 1-phosphate as a link between blood coagulation and inflammation. 2014 Cell. Physiol. Biochem. pmid:24977491
Sattler K et al. HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. 2014 Cell. Physiol. Biochem. pmid:24977490
Thuy AV et al. Sphingosine 1-phosphate in blood: function, metabolism, and fate. 2014 Cell. Physiol. Biochem. pmid:24977489
Ceglarek U et al. Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. 2014 Clin. Chim. Acta pmid:24768784
Brizuela L et al. Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. 2014 Mol Oncol pmid:24768038
Poitevin S et al. Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. 2014 Cardiovasc. Res. pmid:24743591
Mahajan-Thakur S et al. Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. 2014 J. Leukoc. Biol. pmid:24990321
O'Sullivan MJ et al. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. 2014 PLoS ONE pmid:24743449
Jesko H et al. Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. 2014 Folia Neuropathol pmid:24729344
Zhu Y et al. Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. 2014 Mol. Neurobiol. pmid:24722820
Kondo S et al. Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. 2014 PLoS ONE pmid:24714781
Korbelik M et al. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. 2014 Int. Immunopharmacol. pmid:24713544
Gatfield J et al. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. 2014 Cell. Signal. pmid:24704119
Shin KO et al. Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. 2014 Arch. Pharm. Res. pmid:24687256
Blaho VA and Hla T An update on the biology of sphingosine 1-phosphate receptors. 2014 J. Lipid Res. pmid:24459205
Gil-Ortega M et al. Ex vivo microperfusion system of the adipose organ: a new approach to studying the mobilization of adipose cell populations. 2014 Int J Obes (Lond) pmid:24357852
Maeda Y et al. S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1. 2014 Int. Immunol. pmid:24343820
Guo L et al. Roles of sphingosine-1-phosphate in reproduction. 2014 Reprod Sci pmid:24336672
Shen Z et al. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). 2014 Cell Stress Chaperones pmid:24293320
Chen JJ et al. Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. 2014 Steroids pmid:24269742
Whisler JA et al. Control of perfusable microvascular network morphology using a multiculture microfluidic system. 2014 Tissue Eng Part C Methods pmid:24151838
Mendes-Braz M et al. The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. 2014 Liver Int. pmid:24107124
Baranowski M et al. Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. 2014 Int J Sport Nutr Exerc Metab pmid:24092763
Xia JY et al. The adipokine/ceramide axis: key aspects of insulin sensitization. 2014 Biochimie pmid:23969158
Albinet V et al. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. 2014 Oncogene pmid:23893239
Zeng Y et al. Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24285115
Speak AO et al. Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. 2014 Blood pmid:24235134
Nagahashi M et al. Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. 2014 Adv Biol Regul pmid:24210073