Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

Cross Reference

Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Niemann-Pick Disease, Type C D052556 1 associated lipids
Farber Lipogranulomatosis D055577 1 associated lipids
Sensation Disorders D012678 2 associated lipids
Tachycardia, Sinus D013616 2 associated lipids
Ileus D045823 3 associated lipids
Fabry Disease D000795 4 associated lipids
Hematologic Neoplasms D019337 4 associated lipids
Shock, Hemorrhagic D012771 4 associated lipids
Adenomatous Polyps D018256 4 associated lipids
Pregnancy, Ectopic D011271 5 associated lipids
Ovarian Diseases D010049 5 associated lipids
Dilatation, Pathologic D004108 5 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Eye Abnormalities D005124 7 associated lipids
Multiple Sclerosis, Relapsing-Remitting D020529 7 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Teratocarcinoma D018243 7 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Thrombocythemia, Essential D013920 9 associated lipids
Cardiomyopathies D009202 10 associated lipids
Retinal Detachment D012163 10 associated lipids
Influenza, Human D007251 11 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Sciatic Neuropathy D020426 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Lung Injury D055370 14 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Vascular Diseases D014652 16 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Anemia D000740 21 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Fibrosis D005355 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Pulmonary Edema D011654 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Glioblastoma D005909 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Endotoxemia D019446 27 associated lipids
Neuralgia D009437 28 associated lipids
Insulinoma D007340 28 associated lipids
Proteinuria D011507 30 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Acne Vulgaris D000152 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Heart Failure D006333 36 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Asthma D001249 52 associated lipids
Nerve Degeneration D009410 53 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Leukemia D007938 74 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Sabbadini RA Targeting sphingosine-1-phosphate for cancer therapy. 2006 Br. J. Cancer pmid:17024123
Rieken S et al. Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). 2006 J. Biol. Chem. pmid:17023430
Dragusin M et al. Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. 2006 FASEB J. pmid:16877527
Garg SK et al. Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? 2006 Clin. Immunol. pmid:17049310
Mitra P et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17050692
Yatomi Y [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. 2006 Rinsho Byori pmid:16913663
Leclercq TM and Pitson SM Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. 2006 IUBMB Life pmid:16916784
Kohno M et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. 2006 Mol. Cell. Biol. pmid:16980623
Theilmeier G et al. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. 2006 Circulation pmid:16982942
Kihara A [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics]. 2006 Seikagaku pmid:16986722
Birgbauer E and Chun J New developments in the biological functions of lysophospholipids. 2006 Cell. Mol. Life Sci. pmid:16988788
Ryu J et al. Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. 2006 EMBO J. pmid:17124500
Jin YX et al. Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. 2006 Arch. Pharm. Res. pmid:17146975
Taha TA et al. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. 2006 Biochim. Biophys. Acta pmid:17161984
Huwiler A and Pfeilschifter J Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. 2006 Curr. Pharm. Des. pmid:17168766
Ahmad M et al. The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. 2006 Prostaglandins Other Lipid Mediat. pmid:16647641
Wattenberg BW et al. The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. 2006 J. Lipid Res. pmid:16520486
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Pan CY et al. Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. 2006 Neuropharmacology pmid:16616768
Sutherland CM et al. The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. 2006 J. Biol. Chem. pmid:16522638
Fieber CB et al. Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. 2006 Exp. Cell Res. pmid:16527273
Berdyshev EV et al. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. 2006 Cell. Signal. pmid:16529909
Schubert R Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? 2006 Cardiovasc. Res. pmid:16542647
Ochi R et al. Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. 2006 Cardiovasc. Res. pmid:16545787
Betito S and Cuvillier O Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. 2006 Biochem. Biophys. Res. Commun. pmid:16414356
Lee JF et al. Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. 2006 Histochem. Cell Biol. pmid:16416022
Taha TA et al. Sphingosine kinase: biochemical and cellular regulation and role in disease. 2006 J. Biochem. Mol. Biol. pmid:16584625
Malaplate-Armand C et al. Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. 2006 Neurobiol. Dis. pmid:16626961
Lin CI et al. Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. 2006 J. Cell. Biochem. pmid:16795034
Hiraga Y et al. Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells. 2006 Biochem. Biophys. Res. Commun. pmid:16631609
French KJ et al. Antitumor activity of sphingosine kinase inhibitors. 2006 J. Pharmacol. Exp. Ther. pmid:16632640
Milstien S and Spiegel S Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. 2006 Cancer Cell pmid:16530698
Visentin B et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. 2006 Cancer Cell pmid:16530706
Scherer EQ et al. Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? 2006 Cardiovasc. Res. pmid:16533504
Rouach N et al. S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. 2006 Eur. J. Neurosci. pmid:16553609
Brizuela L et al. Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion. 2006 J. Lipid Res. pmid:16554657
Chatterjee S et al. The role of the phospholipid sphingomyelin in heart disease. 2006 Curr Opin Investig Drugs pmid:16555682
Zeidan YH et al. Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. 2006 J. Biol. Chem. pmid:16803890
Dindo D et al. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. 2006 Mol. Cancer Ther. pmid:16818511
Durand CA et al. The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. 2006 Eur. J. Immunol. pmid:16821235
Yan L et al. 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. 2006 Bioorg. Med. Chem. Lett. pmid:16621543
Venkataraman K et al. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. 2006 Biochem. J. pmid:16623665
Weigert A et al. Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. 2006 Blood pmid:16690965
Kim MK et al. Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. 2006 Biochem. Biophys. Res. Commun. pmid:16674917
Xu SZ et al. A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. 2006 Circ. Res. pmid:16675717
Jiang X and Han X Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. 2006 J. Lipid Res. pmid:16682747
Zhang YH et al. Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. 2006 J. Neurophysiol. pmid:16723416
Zhang YH et al. Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. 2006 J. Physiol. (Lond.) pmid:16740613
Hu W et al. Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. 2006 Biochem. Biophys. Res. Commun. pmid:16574065
Zhi L et al. Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. 2006 J. Cell. Physiol. pmid:16575915
Wacker BK et al. Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. 2006 Biomacromolecules pmid:16602758
Hemmings DG et al. Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. 2006 Biol. Reprod. pmid:16162874
Yamashita H et al. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. 2006 J. Surg. Res. pmid:16183075
Sparkman L et al. Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16183668
Wong RC et al. Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. 2006 Biochem. Biophys. Res. Commun. pmid:16616002
Kono M et al. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. 2006 J. Biol. Chem. pmid:16380386
von Otte S et al. Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. 2006 J. Biol. Chem. pmid:16365044
Alewijnse AE and Michel MC Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? 2006 Br. J. Pharmacol. pmid:16402045
Mathieson FA and Nixon GF Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. 2006 Br. J. Pharmacol. pmid:16402047
Chantrain CF et al. Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. 2006 Eur. J. Cancer pmid:16406506
Olivera A et al. IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. 2006 J. Biol. Chem. pmid:16316995
Barthomeuf C et al. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. 2006 Free Radic. Biol. Med. pmid:16458188
Kawamori T et al. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. 2006 FASEB J. pmid:16319132
Roviezzo F et al. Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. 2006 FASEB J. pmid:16322129
Der P et al. Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. 2006 J. Mol. Cell. Cardiol. pmid:16337960
Ramasamy R et al. Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. 2006 Circ. Res. pmid:17008596
Park KS et al. Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. 2006 Mol. Pharmacol. pmid:16368894
Gonzalez E et al. Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. 2006 J. Biol. Chem. pmid:16339142
Dahm F et al. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. 2006 J. Thromb. Haemost. pmid:17010150
Gardell SE et al. Emerging medicinal roles for lysophospholipid signaling. 2006 Trends Mol Med pmid:16406843
Kim MY et al. Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. 2006 Am. J. Physiol., Cell Physiol. pmid:16267108
di Villa Bianca Rd et al. Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. 2006 J. Pharmacol. Exp. Ther. pmid:16234413
Bu S et al. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. 2006 FASEB J. pmid:16278291
Inniss K and Moore H Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate. 2006 Stem Cells Dev. pmid:17253942
Matsuyuki H et al. Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. 2006 Cell. Mol. Immunol. pmid:17257496
Rahaman M et al. Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16224106
Kang JS et al. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. 2006 Mol. Pharmacol. pmid:16354764
Tardieu D et al. Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. 2006 Chem. Biol. Interact. pmid:16412405
Eigenbrod S et al. Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. 2006 Immunol. Invest. pmid:16698674
Hait NC et al. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. 2006 Biochim. Biophys. Acta pmid:16996023
Minshall RD and Malik AB Transport across the endothelium: regulation of endothelial permeability. 2006 Handb Exp Pharmacol pmid:16999218
Smicun Y et al. S1P regulation of ovarian carcinoma invasiveness. 2006 Gynecol. Oncol. pmid:16956652
Squecco R et al. Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. 2006 Mol. Biol. Cell pmid:16957055
Whetzel AM et al. Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. 2006 Circ. Res. pmid:16960101
El-Shewy HM et al. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. 2006 J. Biol. Chem. pmid:16926156
Huang WR et al. [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. 2006 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:16928321
Meriane M et al. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. 2006 Stem Cells pmid:16931773
Bjursell M et al. G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. 2006 Biochem. Biophys. Res. Commun. pmid:16887097
Donati C and Bruni P Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. 2006 Biochim. Biophys. Acta pmid:16890187
Thompson B et al. Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. 2006 Prostaglandins Other Lipid Mediat. pmid:16846783
Long JS et al. The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor. 2006 Prostaglandins Other Lipid Mediat. pmid:16846788
Nagata Y et al. Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling. 2006 J. Cell Biol. pmid:16847102
Xu R et al. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. 2006 FASEB J. pmid:16940153
Schultz C Lipid-induced phenotypes. 2006 Nat. Chem. Biol. pmid:16850012
Brinkmann V and Baumruker T Pulmonary and vascular pharmacology of sphingosine 1-phosphate. 2006 Curr Opin Pharmacol pmid:16563863
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136
Choueiri TK et al. Phenoxodiol: isoflavone analog with antineoplastic activity. 2006 Curr Oncol Rep pmid:16507219
Naetzker S et al. Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. 2006 Genes Cells pmid:16483315
Jurisicova A et al. Molecular requirements for doxorubicin-mediated death in murine oocytes. 2006 Cell Death Differ. pmid:16439991