Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ruwisch L et al. | An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284453 |
van der Weyden L et al. | Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. | 2017 | Nature | pmid:28052056 |
Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
Maceyka M and Spiegel S | Sphingolipid metabolites in inflammatory disease. | 2014 | Nature | pmid:24899305 |
Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
Eisenhoffer GT et al. | Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. | 2012 | Nature | pmid:22504183 |
Vu TM et al. | Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. | 2017 | Nature | pmid:29045386 |
Olivera A and Spiegel S | Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. | 1993 | Nature | pmid:8413613 |
Choi OH et al. | Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. | 1996 | Nature | pmid:8602265 |
Driever W | Developmental biology. Bringing two hearts together. | 2000 | Nature | pmid:10910341 |
Kupperman E et al. | A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. | 2000 | Nature | pmid:10910360 |
Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
Martin R | Multiple sclerosis: closing in on an oral treatment. | 2010 | Nature | pmid:20237554 |
Mendoza A et al. | Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. | 2017 | Nature | pmid:28538737 |
Ishii M et al. | Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. | 2009 | Nature | pmid:19204730 |
Alvarez SE et al. | Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. | 2010 | Nature | pmid:20577214 |
Coursol S et al. | Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. | 2003 | Nature | pmid:12789341 |
Blaho VA et al. | HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. | 2015 | Nature | pmid:26053123 |
Wymann MP and Schneiter R | Lipid signalling in disease. | 2008 | Nat. Rev. Mol. Cell Biol. | pmid:18216772 |
Spiegel S and Milstien S | Sphingosine-1-phosphate: an enigmatic signalling lipid. | 2003 | Nat. Rev. Mol. Cell Biol. | pmid:12728273 |
Hannun YA and Obeid LM | Principles of bioactive lipid signalling: lessons from sphingolipids. | 2008 | Nat. Rev. Mol. Cell Biol. | pmid:18216770 |
Rivera J et al. | The alliance of sphingosine-1-phosphate and its receptors in immunity. | 2008 | Nat. Rev. Immunol. | pmid:18787560 |
Rosen H and Goetzl EJ | Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | 2005 | Nat. Rev. Immunol. | pmid:15999095 |
Spiegel S and Milstien S | The outs and the ins of sphingosine-1-phosphate in immunity. | 2011 | Nat. Rev. Immunol. | pmid:21546914 |
Fletcher JI et al. | ABC transporters in cancer: more than just drug efflux pumps. | 2010 | Nat. Rev. Cancer | pmid:20075923 |
Ogretmen B | Sphingolipid metabolism in cancer signalling and therapy. | 2018 | Nat. Rev. Cancer | pmid:29147025 |
Ogretmen B and Hannun YA | Biologically active sphingolipids in cancer pathogenesis and treatment. | 2004 | Nat. Rev. Cancer | pmid:15286740 |
Pyne NJ and Pyne S | Sphingosine 1-phosphate and cancer. | 2010 | Nat. Rev. Cancer | pmid:20555359 |
Hait NC et al. | Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | 2014 | Nat. Neurosci. | pmid:24859201 |
Lobo MK et al. | Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. | 2007 | Nat. Neurosci. | pmid:17934457 |
Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
Casper RF and Jurisicova A | Protecting the female germ line from cancer therapy. | 2000 | Nat. Med. | pmid:11017136 |
Morita Y et al. | Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. | 2000 | Nat. Med. | pmid:11017141 |
Paris F et al. | Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. | 2002 | Nat. Med. | pmid:12205432 |
Petrache I et al. | Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. | 2005 | Nat. Med. | pmid:15852018 |
Cantalupo A et al. | Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. | 2015 | Nat. Med. | pmid:26301690 |
Garris CS et al. | Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. | 2013 | Nat. Immunol. | pmid:24076635 |
Fang V et al. | Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. | 2017 | Nat. Immunol. | pmid:27841869 |
Walzer T et al. | Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. | 2007 | Nat. Immunol. | pmid:17965716 |
Wei SH et al. | Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. | 2005 | Nat. Immunol. | pmid:16273098 |
Liu G et al. | The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. | 2010 | Nat. Immunol. | pmid:20852647 |
Ramos-Perez WD et al. | A map of the distribution of sphingosine 1-phosphate in the spleen. | 2015 | Nat. Immunol. | pmid:26502404 |
Schwab SR and Cyster JG | Finding a way out: lymphocyte egress from lymphoid organs. | 2007 | Nat. Immunol. | pmid:18026082 |
Ledgerwood LG et al. | The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. | 2008 | Nat. Immunol. | pmid:18037890 |
Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
Mullershausen F et al. | Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. | 2009 | Nat. Chem. Biol. | pmid:19430484 |
Cahalan SM et al. | Actions of a picomolar short-acting S1Pâ‚ agonist in S1Pâ‚-eGFP knock-in mice. | 2011 | Nat. Chem. Biol. | pmid:21445057 |
Fyrst H and Saba JD | An update on sphingosine-1-phosphate and other sphingolipid mediators. | 2010 | Nat. Chem. Biol. | pmid:20559316 |