Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kveberg L et al. | Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. | 2002 | Eur. J. Immunol. | pmid:12115604 |
Morales M | [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. | 2002 | Nefrologia | pmid:12107910 |
Liu H et al. | Sphingosine kinases: a novel family of lipid kinases. | 2002 | Prog. Nucleic Acid Res. Mol. Biol. | pmid:12102559 |
Mallick S et al. | Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells. | 2002 | J. Biosci. | pmid:12089473 |
Kohno T et al. | N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. | 2002 | FASEB J. | pmid:12087059 |
English D et al. | Lipid mediators of angiogenesis and the signalling pathways they initiate. | 2002 | Biochim. Biophys. Acta | pmid:12069833 |
Karliner JS | Lysophospholipids and the cardiovascular system. | 2002 | Biochim. Biophys. Acta | pmid:12069831 |
Siess W | Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate. | 2002 | Biochim. Biophys. Acta | pmid:12069830 |
Panetti TS | Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:12069828 |
Meyer zu Heringdorf D et al. | Sphingosylphosphorylcholine-biological functions and mechanisms of action. | 2002 | Biochim. Biophys. Acta | pmid:12069827 |
Okajima F | Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? | 2002 | Biochim. Biophys. Acta | pmid:12069820 |
Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
Kluk MJ and Hla T | Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069812 |
Le Stunff H et al. | Sphingosine-1-phosphate and lipid phosphohydrolases. | 2002 | Biochim. Biophys. Acta | pmid:12069805 |
Meacci E et al. | A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | 2002 | FEBS Lett. | pmid:12067705 |
Spiegel S et al. | Sphingosine 1-phosphate signaling: providing cells with a sense of direction. | 2002 | Trends Cell Biol. | pmid:12062172 |
Vouret-Craviari V et al. | Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. | 2002 | J. Cell. Sci. | pmid:12045218 |
Cummings RJ et al. | Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. | 2002 | J. Biol. Chem. | pmid:12039947 |