Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sattler K et al. | HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977490 |
Thuy AV et al. | Sphingosine 1-phosphate in blood: function, metabolism, and fate. | 2014 | Cell. Physiol. Biochem. | pmid:24977489 |
van Echten-Deckert G et al. | Sphingosine-1-phosphate: boon and bane for the brain. | 2014 | Cell. Physiol. Biochem. | pmid:24977488 |
Fayyaz S et al. | Divergent role of sphingosine 1-phosphate on insulin resistance. | 2014 | Cell. Physiol. Biochem. | pmid:24977487 |
Halmer R et al. | Sphingolipids: important players in multiple sclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977485 |
Arlt O et al. | Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. | 2014 | Cell. Physiol. Biochem. | pmid:24977479 |
Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
Don AS et al. | Re-configuration of sphingolipid metabolism by oncogenic transformation. | 2014 | Biomolecules | pmid:24970218 |
Snelder N et al. | Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. | 2014 | Drug Metab. Dispos. | pmid:24965813 |
Burow P et al. | Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. | 2015 | Pflugers Arch. | pmid:24965069 |
Nagata Y et al. | Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. | 2014 | Exp. Cell Res. | pmid:24960577 |
Sutter I et al. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. | 2014 | J. Lipid Res. | pmid:24950692 |
Ceccom J et al. | [Sphingosine 1-phosphate as a biomarker for Alzheimer's disease?]. | 2014 | Med Sci (Paris) | pmid:24939530 |
Pan HY et al. | Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. | 2015 | Int Endod J | pmid:24931601 |
Tarbell JM et al. | Mechanosensing at the vascular interface. | 2014 | Annu Rev Biomed Eng | pmid:24905872 |
Deng H et al. | Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. | 2013 | ACS Med Chem Lett | pmid:24900589 |
Maceyka M and Spiegel S | Sphingolipid metabolites in inflammatory disease. | 2014 | Nature | pmid:24899305 |
Arya D et al. | Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. | 2014 | J. Biomed. Sci. | pmid:24898615 |
Potì F et al. | Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). | 2014 | Cardiovasc. Res. | pmid:24891400 |
Chawla S et al. | Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. | 2014 | PLoS ONE | pmid:24887065 |
Janes K et al. | The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. | 2014 | J. Biol. Chem. | pmid:24876379 |
Hait NC et al. | Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | 2014 | Nat. Neurosci. | pmid:24859201 |
Yan W et al. | Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. | 2014 | J. Mol. Cell. Cardiol. | pmid:24852843 |
Sheridan GK and Dev KK | Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. | 2014 | Sci Rep | pmid:24851861 |
Ni X et al. | Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement. | 2014 | J. Cell. Biochem. | pmid:24851274 |
Zhang Y et al. | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. | 2014 | J. Clin. Invest. | pmid:24837436 |
Vanoli E et al. | Vagomimetic effects of fingolimod: physiology and clinical implications. | 2014 | CNS Neurosci Ther | pmid:24836740 |
Purschke WG et al. | Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. | 2014 | Biochem. J. | pmid:24832383 |
Park SM et al. | Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. | 2014 | Eur. J. Immunol. | pmid:24825162 |
Kurano M et al. | Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. | 2014 | Biochim. Biophys. Acta | pmid:24814049 |
Karaca I et al. | Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. | 2014 | J. Biol. Chem. | pmid:24808180 |
Zhang GQ et al. | Sphingosine-1-phosphate receptors respond differently to early myocardial ischemia and ischemia-reperfusion in vivo. | 2014 | Sheng Li Xue Bao | pmid:24777407 |
Ceglarek U et al. | Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. | 2014 | Clin. Chim. Acta | pmid:24768784 |
Park K et al. | The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. | 2014 | J. Nutr. Biochem. | pmid:24768661 |
Brizuela L et al. | Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. | 2014 | Mol Oncol | pmid:24768038 |
Oskeritzian CA | Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. | 2015 | Mol. Immunol. | pmid:24766823 |
de Assuncao TM et al. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. | 2014 | J. Biol. Chem. | pmid:24759103 |
Tong X et al. | The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. | 2014 | Cardiovasc Diabetol | pmid:24751283 |
Poitevin S et al. | Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. | 2014 | Cardiovasc. Res. | pmid:24743591 |
O'Sullivan MJ et al. | Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. | 2014 | PLoS ONE | pmid:24743449 |
Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
Xiong Y and Hla T | S1P control of endothelial integrity. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728594 |
Cahalan SM | Chemical and genetic tools to explore S1P biology. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728593 |
Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
Zhu Y et al. | Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. | 2014 | Mol. Neurobiol. | pmid:24722820 |
Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |