Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Cummings RJ et al. | Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. | 2002 | J. Biol. Chem. | pmid:12039947 |
Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
Yun JK and Kester M | Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | 2002 | Arch. Biochem. Biophys. | pmid:12485605 |
Hirafuji M et al. | [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491784 |
Muraki K et al. | [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491795 |
Graeler M and Goetzl EJ | Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. | 2002 | FASEB J. | pmid:12468451 |
Tanski W et al. | Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | 2002 | J. Surg. Res. | pmid:12443721 |
Osada M et al. | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12445827 |
Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
Chin TY et al. | Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. | 2002 | Mol. Pharmacol. | pmid:11854428 |
Gennero I et al. | Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. | 2002 | J. Biol. Chem. | pmid:11821388 |
Baumruker T and Prieschl EE | Sphingolipids and the regulation of the immune response. | 2002 | Semin. Immunol. | pmid:11884231 |
Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
Meacci E et al. | Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. | 2002 | Biochem. J. | pmid:11853542 |
Lee M and Han SS | Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. | 2002 | Cell. Signal. | pmid:11858945 |
English D | Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | 2002 | Teratology | pmid:11877771 |
Boguslawski G et al. | Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. | 2002 | Exp. Cell Res. | pmid:11900487 |
Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
Idzko M et al. | Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. | 2002 | FASEB J. | pmid:11919175 |
Mandala S et al. | Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. | 2002 | Science | pmid:11923495 |
Ancellin N et al. | Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. | 2002 | J. Biol. Chem. | pmid:11741921 |
Van Brocklyn J et al. | Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | 2002 | Cancer Lett. | pmid:12175535 |
Birbes H et al. | Mitochondria and ceramide: intertwined roles in regulation of apoptosis. | 2002 | Adv. Enzyme Regul. | pmid:12123710 |
Johnson KR et al. | PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). | 2002 | J. Biol. Chem. | pmid:12124383 |
Spiegel S and Milstien S | Sphingosine 1-phosphate, a key cell signaling molecule. | 2002 | J. Biol. Chem. | pmid:12011102 |
Kihara A and Igarashi Y | [Sphingosine 1-phosphate in yeast]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915338 |
Okazaki T and Ito M | [Signal transduction of ceramide]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915339 |
Jin ZQ et al. | Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003800 |
Igarashi Y | [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915345 |
Black JL and Johnson PR | Factors controlling smooth muscle proliferation and airway remodelling. | 2002 | Curr Opin Allergy Clin Immunol | pmid:11964750 |
Okajima F | [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915346 |
Brinkmann V et al. | The immune modulator FTY720 targets sphingosine 1-phosphate receptors. | 2002 | J. Biol. Chem. | pmid:11967257 |
Liu H et al. | Sphingosine kinases: a novel family of lipid kinases. | 2002 | Prog. Nucleic Acid Res. Mol. Biol. | pmid:12102559 |
Morales M | [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. | 2002 | Nefrologia | pmid:12107910 |
Kim DS et al. | Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. | 2002 | Cell. Signal. | pmid:12034359 |
Pyne S | Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis. | 2002 | Subcell. Biochem. | pmid:12037985 |
Takuwa Y et al. | The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. | 2002 | J. Biochem. | pmid:12038970 |
Meacci E et al. | A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. | 2002 | FEBS Lett. | pmid:12067705 |
Le Stunff H et al. | Sphingosine-1-phosphate and lipid phosphohydrolases. | 2002 | Biochim. Biophys. Acta | pmid:12069805 |
Kluk MJ and Hla T | Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069812 |
Siehler S and Manning DR | Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069815 |
Takuwa Y | Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069818 |
Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. | 2002 | Biochim. Biophys. Acta | pmid:12069819 |
Niedernberg A et al. | Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. | 2002 | Biochem. Pharmacol. | pmid:12234605 |
Payne SG et al. | Sphingosine-1-phosphate: dual messenger functions. | 2002 | FEBS Lett. | pmid:12401202 |
Lampasso JD et al. | Role of protein kinase C alpha in primary human osteoblast proliferation. | 2002 | J. Bone Miner. Res. | pmid:12412804 |
Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
Uhlenbrock K et al. | Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. | 2002 | Cell. Signal. | pmid:12220620 |
Tanimoto T et al. | Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). | 2002 | J. Biol. Chem. | pmid:12226078 |
Porcelli AM et al. | Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. | 2002 | Cell. Signal. | pmid:11747992 |
Paik JH et al. | Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | 2001 | J. Biol. Chem. | pmid:11150298 |
Meyer zu Heringdorf D et al. | Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. | 2001 | Eur. J. Pharmacol. | pmid:11239914 |
Young KW and Nahorski SR | Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. | 2001 | Semin. Cell Dev. Biol. | pmid:11162743 |
English D et al. | Platelet-released phospholipids link haemostasis and angiogenesis. | 2001 | Cardiovasc. Res. | pmid:11166272 |
Radin NS | Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? | 2001 | Eur. J. Biochem. | pmid:11168352 |
Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
Rosenfeldt HM et al. | EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. | 2001 | FASEB J. | pmid:11726541 |
Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
Hla T et al. | Lysophospholipids--receptor revelations. | 2001 | Science | pmid:11729304 |
Muraki K and Imaizumi Y | A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. | 2001 | J. Physiol. (Lond.) | pmid:11731576 |
Lee MJ et al. | Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | 2001 | Mol. Cell | pmid:11583630 |
Li G et al. | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | 2001 | Development | pmid:11566853 |
Bischoff A et al. | Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11534858 |
Robert P et al. | EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549339 |
Marletta MA | Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | 2001 | Trends Biochem. Sci. | pmid:11551775 |
Erl W and Siess W | Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | 2001 | Circ. Res. | pmid:11557732 |
Kluk MJ and Hla T | Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | 2001 | Circ. Res. | pmid:11557736 |
Meacci E et al. | Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. | 2001 | Cell. Signal. | pmid:11483412 |
Pébay A et al. | Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | 2001 | Eur. J. Neurosci. | pmid:11467306 |
Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
Igarashi J and Michel T | Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. | 2001 | J. Biol. Chem. | pmid:11470796 |
Garcia JG et al. | Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. | 2001 | J. Clin. Invest. | pmid:11544274 |
Nadal A et al. | Glial cell responses to lipids bound to albumin in serum and plasma. | 2001 | Prog. Brain Res. | pmid:11545003 |
Tamama K et al. | Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. | 2001 | Biochem. J. | pmid:11115407 |
Ohanian J and Ohanian V | Sphingolipids in mammalian cell signalling. | 2001 | Cell. Mol. Life Sci. | pmid:11814056 |
Wang DA et al. | A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. | 2001 | J. Biol. Chem. | pmid:11604399 |
Andor A et al. | YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. | 2001 | Cell. Microbiol. | pmid:11298653 |
Ammit AJ et al. | Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. | 2001 | FASEB J. | pmid:11344091 |
Yatomi Y et al. | Sphingosine 1-phosphate: synthesis and release. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324700 |
Goetzl EJ | Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324701 |
Olivera A and Spiegel S | Sphingosine kinase: a mediator of vital cellular functions. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324702 |
Hla T | Sphingosine 1-phosphate receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324703 |
Mandala SM | Sphingosine-1-phosphate phosphatases. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324704 |
Lynch KR and Macdonald TL | Structure activity relationships of lysophospholipid mediators. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324706 |
Panetti TS et al. | Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324710 |
Alderton F et al. | G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11278307 |
Igarashi J et al. | Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278407 |
Morales-Ruiz M et al. | Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278592 |
Birchwood CJ et al. | Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | 2001 | J. Biol. Chem. | pmid:11278643 |
Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
Kranenburg O and Moolenaar WH | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | 2001 | Oncogene | pmid:11313900 |
Schwartz BM et al. | Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. | 2001 | Gynecol. Oncol. | pmid:11330965 |
Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
Alderton F et al. | Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | 2001 | J. Biol. Chem. | pmid:11359779 |
Pébay A et al. | Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | 2001 | Eur. J. Neurosci. | pmid:11422447 |
Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
Takuwa Y et al. | Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. | 2001 | Mol. Cell. Endocrinol. | pmid:11377814 |
Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |