Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Syed SN et al. | S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. | 2017 | Mediators Inflamm. | pmid:28804221 |
Nicholas SE et al. | Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. | 2017 | PLoS ONE | pmid:28806736 |
Swendeman SL et al. | An engineered S1P chaperone attenuates hypertension and ischemic injury. | 2017 | Sci Signal | pmid:28811382 |
Egom EE et al. | Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. | 2017 | Int J Mol Sci | pmid:28820460 |
Kuchler L et al. | Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. | 2017 | Mol. Immunol. | pmid:28846923 |
Olesch C et al. | Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. | 2017 | Mediators Inflamm. | pmid:28848247 |
Natarajan V et al. | Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. | 2017 | BMC Genomics | pmid:28851267 |
Bosteen MH et al. | Effects of apolipoprotein M in uremic atherosclerosis. | 2017 | Atherosclerosis | pmid:28866363 |
Haddadi N et al. | "Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. | 2017 | Int J Mol Sci | pmid:28869494 |
Anjum I et al. | Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis. | 2017 | Eur. J. Pharmacol. | pmid:28882559 |
Smith P et al. | Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation. | 2017 | Int J Mol Sci | pmid:28934113 |
Du Y et al. | Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. | 2017 | Cell. Physiol. Biochem. | pmid:28934733 |
Reinhard NR et al. | The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. | 2017 | Mol. Biol. Cell | pmid:28954861 |
Werth S et al. | Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. | 2017 | J. Endocrinol. | pmid:28970286 |
Wang X et al. | Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. | 2017 | Exp. Mol. Pathol. | pmid:28986246 |
Mensah SA et al. | Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. | 2017 | PLoS ONE | pmid:29023478 |
Schmidt KG et al. | Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. | 2017 | Front Immunol | pmid:29033951 |
Vu TM et al. | Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. | 2017 | Nature | pmid:29045386 |
Katsuta E et al. | Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. | 2017 | J. Surg. Res. | pmid:29078883 |
Tran HB et al. | Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. | 2017 | PLoS ONE | pmid:29112690 |
Wang M et al. | Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. | 2017 | PLoS ONE | pmid:29136008 |
Ogretmen B | Sphingolipid metabolism in cancer signalling and therapy. | 2018 | Nat. Rev. Cancer | pmid:29147025 |
Huang Y et al. | S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. | 2018 | Science | pmid:29302015 |
Książek M et al. | Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. | 2018 | Cell. Physiol. Biochem. | pmid:29316552 |
Deshpande GP et al. | Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). | 2018 | Life Sci. | pmid:29373815 |
Nádró B et al. | [The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis]. | 2018 | Orv Hetil | pmid:29376427 |
Tang HB et al. | S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29534963 |
Yu FC et al. | Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29550481 |
Yatomi Y et al. | Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. | 1995 | Anal. Biochem. | pmid:7503424 |
Törnquist K et al. | Sphingosine derivatives inhibit depolarization-evoked calcium entry in rat GH4C1 cells. | 1995 | Endocrinology | pmid:7588222 |
Gómez-Muñoz A et al. | Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. | 1995 | J. Biol. Chem. | pmid:7592842 |
Eggerickx D et al. | Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. | 1995 | Biochem. J. | pmid:7639700 |
Liu R et al. | Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: psychosine elicits release of calcium from intracellualr stores. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677781 |
Durieux ME et al. | Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling. | 1993 | Am. J. Physiol. | pmid:7684565 |
Goodemote KA et al. | Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate. | 1995 | J. Biol. Chem. | pmid:7730331 |
Jalink K et al. | Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis. | 1995 | Biochem. J. | pmid:7733903 |
Wu J et al. | Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. | 1995 | J. Biol. Chem. | pmid:7744787 |
Bornfeldt KE et al. | Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. | 1995 | J. Cell Biol. | pmid:7790372 |
Yatomi Y et al. | Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets. | 1995 | Blood | pmid:7795224 |
Pushkareva M et al. | Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. | 1995 | Biochemistry | pmid:7849048 |
Spiegel S et al. | Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells. | 1994 | Breast Cancer Res. Treat. | pmid:7881110 |
Boumendjel A and Miller SP | Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. | 1994 | J. Lipid Res. | pmid:7897327 |
Natarajan V et al. | Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8049083 |
Ghosh TK et al. | Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. | 1994 | J. Biol. Chem. | pmid:8077214 |
Mattie M et al. | Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. | 1994 | J. Biol. Chem. | pmid:8106352 |
Sadahira Y et al. | Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells. | 1994 | FEBS Lett. | pmid:8119417 |
Su Y et al. | Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. | 1994 | J. Biol. Chem. | pmid:8206962 |
Spiegel S | Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid. | 1993 | J Lipid Mediat | pmid:8268463 |
Mazurek N et al. | Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8292009 |
Desai NN et al. | Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. | 1993 | J. Cell Biol. | pmid:8389770 |