Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
Maupas-Schwalm F et al. | The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | 2004 | FASEB J. | pmid:15231724 |
Fujita T et al. | Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | 2004 | Biochem. J. | pmid:15193146 |
Brinkmann V et al. | FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | 2004 | Am. J. Transplant. | pmid:15196057 |
Im DS et al. | Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. | 2004 | J. Pharmacol. Sci. | pmid:15215654 |
Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
Cui J et al. | Role of ceramide in ischemic preconditioning. | 2004 | J. Am. Coll. Surg. | pmid:15110811 |
Jolly PS et al. | Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. | 2004 | J. Exp. Med. | pmid:15067032 |
Segura BJ et al. | Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. | 2004 | J. Surg. Res. | pmid:14732348 |
Sanna MG et al. | Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. | 2004 | J. Biol. Chem. | pmid:14732717 |
Forrest M et al. | Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14747617 |
Yue J et al. | Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. | 2004 | Cell. Signal. | pmid:14687668 |
Harada J et al. | Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | 2004 | J. Neurochem. | pmid:14756825 |
Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
Panetti TS et al. | Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | 2004 | J. Thromb. Haemost. | pmid:15333043 |
Gräler MH and Goetzl EJ | The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. | 2004 | FASEB J. | pmid:14715694 |
Ohmori T et al. | Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2004 | J. Thromb. Haemost. | pmid:14717991 |
Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
Holdsworth G et al. | A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. | 2004 | BMC Biochem. | pmid:15298705 |
Anliker B and Chun J | Cell surface receptors in lysophospholipid signaling. | 2004 | Semin. Cell Dev. Biol. | pmid:15271291 |
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Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
Kohno T and Igarashi Y | Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. | 2004 | Glycoconj. J. | pmid:15750791 |
Linz-McGillem LA et al. | Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation. | 2004 | Stem Cells Dev. | pmid:15588507 |
Barber SC et al. | S1P and LPA trigger Schwann cell actin changes and migration. | 2004 | Eur. J. Neurosci. | pmid:15217370 |
Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
Yatomi Y et al. | Sphingosine 1-phosphate breakdown in platelets. | 2004 | J. Biochem. | pmid:15625319 |
Hammer S et al. | Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. | 2004 | J. Cell. Biochem. | pmid:14991774 |
Tokuda H et al. | Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | 2004 | J. Cell. Biochem. | pmid:15034939 |
Goetzl EJ and Gräler MH | Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. | 2004 | J. Leukoc. Biol. | pmid:14982946 |
Fukuda Y et al. | Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation. | 2004 | Biochim. Biophys. Acta | pmid:14984734 |
Tanimoto T et al. | Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. | 2004 | Circ. Res. | pmid:15044318 |
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Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
Nakamura H et al. | Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. | 2004 | Biochem. Pharmacol. | pmid:15498509 |
Billich A and Ettmayer P | Fluorescence-based assay of sphingosine kinases. | 2004 | Anal. Biochem. | pmid:14769343 |
Liu S et al. | Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. | 2004 | J. Biol. Chem. | pmid:15466414 |
Birukov KG et al. | Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | 2004 | Circ. Res. | pmid:15472119 |
Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
Nosi D et al. | Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | 2004 | Cells Tissues Organs (Print) | pmid:15655330 |
Xin C et al. | Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15466446 |
Ozbay T et al. | ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. | 2004 | Endocr. Res. | pmid:15666826 |
Elices MJ | Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | 2004 | Curr Opin Investig Drugs | pmid:15573862 |
Kelley GG et al. | Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | 2004 | Biochem. J. | pmid:14567755 |
Yu N et al. | Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | 2004 | Glia | pmid:14648542 |
Formigli L et al. | Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells. | 2004 | J. Cell. Physiol. | pmid:14584038 |
Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
Gonzalez E et al. | Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | 2004 | J. Biol. Chem. | pmid:15292187 |
Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |
Chavakis T et al. | Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. | 2004 | FASEB J. | pmid:15208269 |
Xu CB et al. | Sphingosine signaling and atherogenesis. | 2004 | Acta Pharmacol. Sin. | pmid:15210056 |
Yokoo E et al. | Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells. | 2004 | J. Biochem. | pmid:15213242 |
Pierre SC et al. | PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. | 2004 | EMBO J. | pmid:15257286 |
McVerry BJ and Garcia JG | Endothelial cell barrier regulation by sphingosine 1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258893 |
Karliner JS | Mechanisms of cardioprotection by lysophospholipids. | 2004 | J. Cell. Biochem. | pmid:15258895 |
Goetzl EJ et al. | Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. | 2004 | J. Cell. Biochem. | pmid:15258896 |
Le Stunff H et al. | Generation and metabolism of bioactive sphingosine-1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258913 |
Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |
Deretic D et al. | Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors. | 2004 | Mol. Biol. Cell | pmid:13679519 |
Ikeda H et al. | Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15240112 |
Misasi R et al. | Prosaposin: a new player in cell death prevention of U937 monocytic cells. | 2004 | Exp. Cell Res. | pmid:15242760 |
Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
Stahelin RV et al. | The mechanism of membrane targeting of human sphingosine kinase 1. | 2005 | J. Biol. Chem. | pmid:16243846 |
Lindner K et al. | Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. | 2005 | Br. J. Pharmacol. | pmid:15735657 |
Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
Yabu T et al. | Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | 2005 | Blood | pmid:15741222 |
Vessey DA et al. | A rapid radioassay for sphingosine kinase. | 2005 | Anal. Biochem. | pmid:15649386 |
Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
Mizugishi K et al. | Essential role for sphingosine kinases in neural and vascular development. | 2005 | Mol. Cell. Biol. | pmid:16314531 |
Armulik A et al. | Endothelial/pericyte interactions. | 2005 | Circ. Res. | pmid:16166562 |
Itagaki K et al. | Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. | 2005 | J. Leukoc. Biol. | pmid:15522918 |
Chun J | Lysophospholipids in the nervous system. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099390 |
Formigli L et al. | Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels. | 2005 | J. Cell. Sci. | pmid:15728255 |
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Inagaki Y et al. | Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. | 2005 | Biochem. J. | pmid:15733055 |
Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
Murakami T et al. | Synthesis and biological properties of novel sphingosine derivatives. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15686924 |
Edsbagge J et al. | Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. | 2005 | Development | pmid:15689381 |
Jaillard C et al. | Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. | 2005 | J. Neurosci. | pmid:15703400 |
Geoffroy K et al. | Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. | 2005 | FEBS Lett. | pmid:15710421 |
Duan HF et al. | [Establishment of a method for determining the sphingosine kinase activity and its initial application]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180179 |
Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
Zaslavsky A et al. | Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. | 2005 | FEBS Lett. | pmid:15987639 |
Chae SS and Hla T | Inhibition of gene expression in vivo using multiplex siRNA. | 2005 | Methods Mol. Biol. | pmid:15990401 |
Berdyshev EV et al. | Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15766719 |
Long J et al. | Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. | 2005 | Biochem. J. | pmid:15960610 |
Malchinkhuu E et al. | Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. | 2005 | Oncogene | pmid:16007180 |