Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
Kolahdooz Z et al. | Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. | 2015 | Can J Neurol Sci | pmid:25860537 |
Pal SK et al. | A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. | 2017 | Cancer | pmid:27727447 |
Yang F et al. | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. | 2012 | Cancer Biol. Ther. | pmid:22406995 |
Beljanski V et al. | Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. | 2011 | Cancer Biol. Ther. | pmid:21258214 |
Milstien S and Spiegel S | Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. | 2006 | Cancer Cell | pmid:16530698 |
Visentin B et al. | Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. | 2006 | Cancer Cell | pmid:16530706 |
Liang J et al. | Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. | 2013 | Cancer Cell | pmid:23273921 |
Alberg AJ et al. | Plasma sphingolipids and lung cancer: a population-based, nested case-control study. | 2013 | Cancer Epidemiol. Biomarkers Prev. | pmid:23749868 |
Sutphen R et al. | Lysophospholipids are potential biomarkers of ovarian cancer. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15247129 |
Rolin J et al. | FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. | 2010 | Cancer Immunol. Immunother. | pmid:19823820 |
Dai L et al. | Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? | 2014 | Cancer Invest. | pmid:24499107 |
Vishwakarma S et al. | Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. | 2017 | Cancer Invest. | pmid:28135860 |
Sun DF et al. | Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. | 2012 | Cancer Lett. | pmid:22261335 |
Li MH et al. | S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. | 2009 | Cancer Lett. | pmid:19131156 |
Li X et al. | Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability. | 2009 | Cancer Lett. | pmid:19446953 |
Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
Van Brocklyn J et al. | Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. | 2002 | Cancer Lett. | pmid:12175535 |
Karahatay S et al. | Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. | 2007 | Cancer Lett. | pmid:17619081 |
Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
Yester JW et al. | Extracellular and intracellular sphingosine-1-phosphate in cancer. | 2011 | Cancer Metastasis Rev. | pmid:22002715 |
Li MH et al. | Sphingolipid modulation of angiogenic factor expression in neuroblastoma. | 2011 | Cancer Prev Res (Phila) | pmid:21576349 |
Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
Goetzl EJ et al. | Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. | 1999 | Cancer Res. | pmid:10493533 |
Goetzl EJ et al. | Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. | 1999 | Cancer Res. | pmid:10537322 |
Kilbey A et al. | Runx regulation of sphingolipid metabolism and survival signaling. | 2010 | Cancer Res. | pmid:20587518 |
Pchejetski D et al. | Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. | 2005 | Cancer Res. | pmid:16357178 |
Shida D et al. | Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. | 2008 | Cancer Res. | pmid:18701480 |
Bonnaud S et al. | Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. | 2007 | Cancer Res. | pmid:17308123 |
Ader I et al. | When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | 2009 | Cancer Res. | pmid:19383898 |
Wang F et al. | Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. | 1999 | Cancer Res. | pmid:10626811 |
Bonnaud S et al. | Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. | 2010 | Cancer Res. | pmid:21118968 |
Clair T et al. | Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. | 2003 | Cancer Res. | pmid:14500380 |
Pyne S et al. | Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. | 2011 | Cancer Res. | pmid:21940750 |
Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
Taniguchi K et al. | Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. | 2009 | Cancer Sci. | pmid:19493272 |
Wang F and Fishman DA | Lysophosphatidic acid and invasion. | 2009 | Cancer Treat. Res. | pmid:19763441 |
Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
Xu Y et al. | Lipid generation and signaling in ovarian cancer. | 2009 | Cancer Treat. Res. | pmid:19763440 |
Chumanevich AA et al. | Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. | 2010 | Carcinogenesis | pmid:20688834 |
Tong X et al. | The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. | 2014 | Cardiovasc Diabetol | pmid:24751283 |
Tong X et al. | High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. | 2013 | Cardiovasc Diabetol | pmid:23360427 |
Somers SJ et al. | Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. | 2012 | Cardiovasc Drugs Ther | pmid:22392184 |
Deshpande GP et al. | Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF). | 2010 | Cardiovasc Drugs Ther | pmid:20838867 |
Kelly-Laubscher RF et al. | Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3. | Cardiovasc J Afr | pmid:25000441 | |
Meissner A et al. | Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. | 2017 | Cardiovasc. Res. | pmid:28082452 |
Ohmori T et al. | Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2003 | Cardiovasc. Res. | pmid:12667959 |
Witt W et al. | Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves. | 2012 | Cardiovasc. Res. | pmid:22232739 |
Choi SK et al. | Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery. | 2009 | Cardiovasc. Res. | pmid:19218288 |
Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | 2006 | Cardiovasc. Res. | pmid:16542647 |
Ochi R et al. | Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | 2006 | Cardiovasc. Res. | pmid:16545787 |
Scherer EQ et al. | Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies? | 2006 | Cardiovasc. Res. | pmid:16533504 |
Frias MA et al. | Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. | 2010 | Cardiovasc. Res. | pmid:19700468 |
Dueñas AI et al. | Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate. | 2008 | Cardiovasc. Res. | pmid:18411230 |
Karliner JS | Sphingosine kinase regulation and cardioprotection. | 2009 | Cardiovasc. Res. | pmid:19017750 |
English D et al. | Platelet-released phospholipids link haemostasis and angiogenesis. | 2001 | Cardiovasc. Res. | pmid:11166272 |
Frias MA et al. | Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. | 2009 | Cardiovasc. Res. | pmid:19151362 |
Takashima S et al. | G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. | 2008 | Cardiovasc. Res. | pmid:18480127 |
Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. | 2007 | Cardiovasc. Res. | pmid:17331485 |
Potì F et al. | Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). | 2014 | Cardiovasc. Res. | pmid:24891400 |
Morel S et al. | Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. | 2016 | Cardiovasc. Res. | pmid:26762268 |
Hofmann U et al. | Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. | 2009 | Cardiovasc. Res. | pmid:19416991 |
Böhm A et al. | Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. | 2013 | Cardiovasc. Res. | pmid:23658376 |
Poitevin S et al. | Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. | 2014 | Cardiovasc. Res. | pmid:24743591 |
Sugiyama A et al. | Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. | 2000 | Cardiovasc. Res. | pmid:10727660 |
Heller R et al. | Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. | 2008 | Cardiovasc. Res. | pmid:18558630 |
Yan G et al. | Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. | 2008 | Cardiovasc. Res. | pmid:18192241 |
Lidington D et al. | Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. | 2013 | Cardiovasc. Res. | pmid:23180720 |
Jin ZQ et al. | A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. | 2007 | Cardiovasc. Res. | pmid:17610857 |
Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
Gellings Lowe N et al. | Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts. | 2009 | Cardiovasc. Res. | pmid:19228708 |
Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. | 2009 | Cardiovasc. Res. | pmid:19233865 |
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Morel S et al. | The natural cardioprotective particle HDL modulates connexin43 gap junction channels. | 2012 | Cardiovasc. Res. | pmid:21960685 |
Oyama O et al. | The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. | 2008 | Cardiovasc. Res. | pmid:18187460 |
Yu FX et al. | Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. | 2012 | Cell | pmid:22863277 |
Lee MJ et al. | Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. | 1999 | Cell | pmid:10555146 |
Konstantinou D et al. | Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor. | 2015 | Cell Biol. Int. | pmid:25492631 |
Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
Beech DJ et al. | TRPC channel lipid specificity and mechanisms of lipid regulation. | 2009 | Cell Calcium | pmid:19324410 |
Orlati S et al. | Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilize cytosolic calcium through different mechanisms in human airway epithelial cells. | 1998 | Cell Calcium | pmid:9924630 |
Lepannetier S et al. | Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. | 2016 | Cell Calcium | pmid:27638096 |
AL-Shawaf E et al. | GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. | 2011 | Cell Calcium | pmid:21742378 |
Shin Y et al. | Diverse effects of sphingosine on calcium mobilization and influx in differentiated HL-60 cells. | 2000 | Cell Calcium | pmid:10859593 |
Lee HS et al. | Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. | 2005 | Cell Calcium | pmid:16219349 |
Ohtoyo M et al. | Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. | 2016 | Cell Chem Biol | pmid:27185637 |
Aas V et al. | Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. | 2001 | Cell Commun. Adhes. | pmid:11936187 |
Oh YT et al. | DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. | 2017 | Cell Commun. Signal | pmid:28482915 |
Oskouian B and Saba J | Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. | 2007 | Cell Cycle | pmid:17361098 |
Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
Hagen N et al. | Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. | 2011 | Cell Death Differ. | pmid:21331079 |
Lépine S et al. | Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. | 2011 | Cell Death Differ. | pmid:20798685 |
Medina CB and Ravichandran KS | Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. | 2016 | Cell Death Differ. | pmid:26891690 |
Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
Innamorati G et al. | Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. | 2017 | Cell Death Dis | pmid:28703804 |
Kumar A et al. | S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. | 2011 | Cell Death Dis | pmid:21368890 |
Kumar A et al. | Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. | 2004 | Cell Motil. Cytoskeleton | pmid:15476260 |