Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Afrasiabi E et al. | Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. | 2006 | Cell. Signal. | pmid:16490345 |
Sabbadini RA | Targeting sphingosine-1-phosphate for cancer therapy. | 2006 | Br. J. Cancer | pmid:17024123 |
Dragusin M et al. | Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. | 2006 | FASEB J. | pmid:16877527 |
Garg SK et al. | Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? | 2006 | Clin. Immunol. | pmid:17049310 |
Mitra P et al. | Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17050692 |
Yatomi Y | [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | 2006 | Rinsho Byori | pmid:16913663 |
Leclercq TM and Pitson SM | Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. | 2006 | IUBMB Life | pmid:16916784 |
Kohno M et al. | Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. | 2006 | Mol. Cell. Biol. | pmid:16980623 |
Ahmad M et al. | The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647641 |
Pan CY et al. | Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells. | 2006 | Neuropharmacology | pmid:16616768 |
Sutherland CM et al. | The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. | 2006 | J. Biol. Chem. | pmid:16522638 |
Fieber CB et al. | Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. | 2006 | Exp. Cell Res. | pmid:16527273 |
Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | 2006 | Cardiovasc. Res. | pmid:16542647 |
Ochi R et al. | Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | 2006 | Cardiovasc. Res. | pmid:16545787 |
Betito S and Cuvillier O | Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16414356 |
Lee JF et al. | Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. | 2006 | Histochem. Cell Biol. | pmid:16416022 |
Taha TA et al. | Sphingosine kinase: biochemical and cellular regulation and role in disease. | 2006 | J. Biochem. Mol. Biol. | pmid:16584625 |
Lin CI et al. | Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. | 2006 | J. Cell. Biochem. | pmid:16795034 |
Weigert A et al. | Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. | 2006 | Blood | pmid:16690965 |
Kim MK et al. | Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16674917 |
Xu SZ et al. | A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. | 2006 | Circ. Res. | pmid:16675717 |
Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
Zhang YH et al. | Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. | 2006 | J. Neurophysiol. | pmid:16723416 |
Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
Hu W et al. | Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16574065 |
Zhi L et al. | Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. | 2006 | J. Cell. Physiol. | pmid:16575915 |
Wacker BK et al. | Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. | 2006 | Biomacromolecules | pmid:16602758 |
Wong RC et al. | Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16616002 |
Mathieson FA and Nixon GF | Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. | 2006 | Br. J. Pharmacol. | pmid:16402047 |
Chantrain CF et al. | Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. | 2006 | Eur. J. Cancer | pmid:16406506 |
Olivera A et al. | IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. | 2006 | J. Biol. Chem. | pmid:16316995 |
Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
Kawamori T et al. | Sphingosine kinase 1 is up-regulated in colon carcinogenesis. | 2006 | FASEB J. | pmid:16319132 |
Roviezzo F et al. | Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. | 2006 | FASEB J. | pmid:16322129 |
Der P et al. | Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. | 2006 | J. Mol. Cell. Cardiol. | pmid:16337960 |
Ramasamy R et al. | Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. | 2006 | Circ. Res. | pmid:17008596 |
Gonzalez E et al. | Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. | 2006 | J. Biol. Chem. | pmid:16339142 |
Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
Gardell SE et al. | Emerging medicinal roles for lysophospholipid signaling. | 2006 | Trends Mol Med | pmid:16406843 |
Rahaman M et al. | Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16224106 |
Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
Eigenbrod S et al. | Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. | 2006 | Immunol. Invest. | pmid:16698674 |
Smicun Y et al. | S1P regulation of ovarian carcinoma invasiveness. | 2006 | Gynecol. Oncol. | pmid:16956652 |
Squecco R et al. | Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. | 2006 | Mol. Biol. Cell | pmid:16957055 |
Whetzel AM et al. | Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | 2006 | Circ. Res. | pmid:16960101 |
El-Shewy HM et al. | Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. | 2006 | J. Biol. Chem. | pmid:16926156 |
Huang WR et al. | [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. | 2006 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16928321 |
Meriane M et al. | Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. | 2006 | Stem Cells | pmid:16931773 |
Bjursell M et al. | G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16887097 |