Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garris CS et al. | Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. | 2013 | Nat. Immunol. | pmid:24076635 |
| Koch A et al. | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | 2013 | Biochim. Biophys. Acta | pmid:23906789 |
| Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
| Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
| Zhao CG et al. | Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. | 2013 | Physiol Res | pmid:23869887 |
| Knapp M et al. | Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24120760 |
| Arce FT et al. | Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. | 2013 | Nanomedicine | pmid:23523769 |
| Herr DR et al. | Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. | 2013 | J. Biol. Chem. | pmid:24003216 |
| Dave JM et al. | Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). | 2013 | J. Biol. Chem. | pmid:24005669 |
| Southern C et al. | Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. | 2013 | J Biomol Screen | pmid:23396314 |
| Wang X et al. | Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. | 2013 | Biochem. Pharmacol. | pmid:24134913 |
| Mierzejewska K et al. | Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow. | 2013 | Biomed Res Int | pmid:24490172 |
| Ley S et al. | The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. | 2013 | Oncogene | pmid:22410777 |
| Dziak R | The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. | 2013 | Immunol. Invest. | pmid:24004055 |
| Beckham TH et al. | Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. | 2013 | PLoS ONE | pmid:24098536 |
| Xiong Y et al. | Sphingosine kinases are not required for inflammatory responses in macrophages. | 2013 | J. Biol. Chem. | pmid:24081141 |
| Zhang W et al. | ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. | 2013 | J. Biol. Chem. | pmid:24064218 |
| Babahosseini H et al. | Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. | 2013 | Integr Biol (Camb) | pmid:24056950 |
| Zhang O et al. | Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. | 2013 | Mol. Microbiol. | pmid:23980754 |
| Olivera A et al. | Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. | 2013 | J. Leukoc. Biol. | pmid:23904439 |
| Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
| Liu Y et al. | Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. | 2013 | J. Pathol. | pmid:23839903 |
| Riccitelli E et al. | Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. | 2013 | PLoS ONE | pmid:23826381 |
| Wang Y et al. | Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. | 2013 | Endocrinology | pmid:23787120 |
| Wang Z et al. | Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. | 2013 | Structure | pmid:23602659 |
| Salmanzadeh A et al. | Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. | 2013 | Integr Biol (Camb) | pmid:23609351 |
| Orr Gandy KA et al. | Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. | 2013 | FASEB J. | pmid:23629860 |
| Schneider G et al. | Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. | 2013 | Mol. Cancer Res. | pmid:23615526 |
| Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. | 2013 | PLoS ONE | pmid:23326540 |
| Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23307289 |
| Sharma N et al. | Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. | 2013 | J. Leukoc. Biol. | pmid:23345392 |
| Salvemini D et al. | Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. | 2013 | Trends Pharmacol. Sci. | pmid:23318139 |
| Tibolla G et al. | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. | 2013 | PLoS ONE | pmid:23320105 |
| Lee YJ et al. | Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. | 2013 | Int. J. Mol. Med. | pmid:23381659 |
| Yangyuoru PM et al. | Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. | 2013 | Methods Mol. Biol. | pmid:23386355 |
| Dillahunt SE et al. | Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. | 2013 | J. Immunol. | pmid:23359503 |
| Tong X et al. | High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. | 2013 | Cardiovasc Diabetol | pmid:23360427 |
| Del Galdo S et al. | The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. | 2013 | Cell. Signal. | pmid:23993968 |
| Di Menna L et al. | Fingolimod protects cultured cortical neurons against excitotoxic death. | 2013 | Pharmacol. Res. | pmid:23073075 |
| Zu Heringdorf DM et al. | Pharmacology of the sphingosine-1-phosphate signalling system. | 2013 | Handb Exp Pharmacol | pmid:23579459 |
| Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
| Park K et al. | Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. | 2013 | J. Invest. Dermatol. | pmid:23856934 |
| O'Sullivan C and Dev KK | The structure and function of the S1P1 receptor. | 2013 | Trends Pharmacol. Sci. | pmid:23763867 |
| Chang CH et al. | Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. | 2013 | Acta Pharmacol. Sin. | pmid:23377549 |
| Cuvillier O et al. | Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. | 2013 | Adv. Cancer Res. | pmid:23290779 |
| Alshaker H et al. | Therapeutic potential of targeting SK1 in human cancers. | 2013 | Adv. Cancer Res. | pmid:23290780 |
| Heffernan-Stroud LA and Obeid LM | Sphingosine kinase 1 in cancer. | 2013 | Adv. Cancer Res. | pmid:23290781 |
| Zhang J et al. | Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. | 2013 | Hum. Reprod. | pmid:24001716 |
| Kihara A | [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. | 2013 | Seikagaku | pmid:23980469 |
| Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |