Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Paik JH et al. | Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. | 2001 | J. Biol. Chem. | pmid:11150298 |
Pébay A et al. | Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | 2001 | Eur. J. Neurosci. | pmid:11467306 |
Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
Igarashi J and Michel T | Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. | 2001 | J. Biol. Chem. | pmid:11470796 |
Hla T | Sphingosine 1-phosphate receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324703 |
Mandala SM | Sphingosine-1-phosphate phosphatases. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11324704 |
Renault AD et al. | Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. | 2002 | Gene Expr. Patterns | pmid:12617823 |
Candelore MR et al. | Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12270137 |
Gennero I et al. | Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density. | 2002 | J. Biol. Chem. | pmid:11821388 |
Baumruker T and Prieschl EE | Sphingolipids and the regulation of the immune response. | 2002 | Semin. Immunol. | pmid:11884231 |
Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
Min JK et al. | Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. | 2002 | Anal. Biochem. | pmid:11950216 |
Essler M et al. | Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. | 2002 | Cell. Signal. | pmid:11955953 |
Endo A et al. | Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. | 2002 | J. Biol. Chem. | pmid:11956190 |
Bartholomä P et al. | Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. | 2002 | Biochem. Pharmacol. | pmid:11996893 |
Formigli L et al. | Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11997251 |
Schilling T et al. | Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels. | 2002 | Neuroscience | pmid:11927165 |
Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |
Koide Y et al. | Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. | 2002 | J. Med. Chem. | pmid:12361389 |
Tamama K and Okajima F | Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology. | 2002 | Curr. Opin. Lipidol. | pmid:12352012 |