Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
Choueiri TK et al. | Phenoxodiol: isoflavone analog with antineoplastic activity. | 2006 | Curr Oncol Rep | pmid:16507219 |
Naetzker S et al. | Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | 2006 | Genes Cells | pmid:16483315 |
Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |
von Wenckstern H et al. | The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. | 2006 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:16830220 |
Shimizu T et al. | Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. | 2007 | Circ. Res. | pmid:17872461 |
Kunisawa J et al. | Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. | 2007 | J. Exp. Med. | pmid:17875673 |
Fujiwara Y et al. | Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | 2007 | J. Biol. Chem. | pmid:17114791 |
Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
Kume H et al. | Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17105828 |
Brahmbhatt VV et al. | Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. | 2007 | Chem. Phys. Lipids | pmid:17126823 |
Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | 2007 | Blood | pmid:17234743 |
Martino A et al. | Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | 2007 | Scand. J. Immunol. | pmid:17212771 |
Johnstone ED et al. | Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17913870 |
Hänel P et al. | Erythrocytes store and release sphingosine 1-phosphate in blood. | 2007 | FASEB J. | pmid:17215483 |
Siow DL and Wattenberg BW | An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. | 2007 | Anal. Biochem. | pmid:17884005 |
Gonzalez-Cabrera PJ et al. | Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. | 2007 | J. Biol. Chem. | pmid:17218309 |
Maceyka M et al. | Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. | 2007 | Meth. Enzymol. | pmid:17954251 |
Igarashi J et al. | Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | 2007 | Br. J. Pharmacol. | pmid:17220911 |
Mitra P et al. | A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. | 2007 | Meth. Enzymol. | pmid:17954252 |
Maceyka M et al. | Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. | 2007 | Circ. Res. | pmid:17204658 |
Martino A | Sphingosine 1-phosphate as a novel immune regulator of dendritic cells. | 2007 | J. Biosci. | pmid:17954981 |
Guo Y et al. | Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | 2007 | Mol. Cell Proteomics | pmid:17210631 |
Nofer JR et al. | FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. | 2007 | Circulation | pmid:17242282 |
Alemany R et al. | Regulation and functional roles of sphingosine kinases. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17242884 |
Kim M et al. | Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17898040 |
Tan SY et al. | Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines. | 2007 | Front. Biosci. | pmid:17127411 |
Alvarez SE et al. | Autocrine and paracrine roles of sphingosine-1-phosphate. | 2007 | Trends Endocrinol. Metab. | pmid:17904858 |
Deng Q et al. | Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies. | 2007 | Mol. Pharmacol. | pmid:17170199 |
Braun A et al. | Paucity of pericytes in germinal matrix vasculature of premature infants. | 2007 | J. Neurosci. | pmid:17978043 |
Hinson JS et al. | Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16997888 |
Van Brocklyn JR | Sphingolipid signaling pathways as potential therapeutic targets in gliomas. | 2007 | Mini Rev Med Chem | pmid:17979800 |
Zhao Y et al. | Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | 2007 | J. Biol. Chem. | pmid:17379599 |
Sato K et al. | Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes. | 2007 | J. Neurochem. | pmid:17931360 |
Matsuo Y et al. | Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation. | 2007 | Atherosclerosis | pmid:17118370 |
Nodai A et al. | Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | 2007 | Life Sci. | pmid:17382352 |
Baumruker T et al. | FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. | 2007 | Expert Opin Investig Drugs | pmid:17302523 |
Baran Y et al. | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | 2007 | J. Biol. Chem. | pmid:17303574 |
Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
Jung ID et al. | Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. | 2007 | Int. Immunol. | pmid:17307797 |
Bonnaud S et al. | Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. | 2007 | Cancer Res. | pmid:17308123 |
Xue X et al. | Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17360805 |
Oskouian B and Saba J | Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. | 2007 | Cell Cycle | pmid:17361098 |
Nyalendo C et al. | Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. | 2007 | J. Biol. Chem. | pmid:17389600 |
Okazaki M et al. | Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. | 2007 | Am. J. Transplant. | pmid:17391120 |
Milstien S et al. | Sphingosine 1-phosphate in neural signalling and function. | 2007 | Acta Paediatr Suppl | pmid:17391440 |
Michel MC et al. | Vascular effects of sphingolipids. | 2007 | Acta Paediatr Suppl | pmid:17391441 |
Goetzl EJ et al. | Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. | 2007 | Acta Paediatr Suppl | pmid:17391442 |
Lobo MK et al. | Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6. | 2007 | Nat. Neurosci. | pmid:17934457 |
Peters SL and Alewijnse AE | Sphingosine-1-phosphate signaling in the cardiovascular system. | 2007 | Curr Opin Pharmacol | pmid:17280869 |
Tellier E et al. | Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. | 2007 | Mol. Cell. Biol. | pmid:17283058 |
Morales A et al. | Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo. | 2007 | Oncogene | pmid:16862171 |
Jiang LI et al. | Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway. | 2007 | J. Biol. Chem. | pmid:17283075 |
Cai Q et al. | Validation of fumonisin biomarkers in F344 rats. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904604 |
Rosen H et al. | Tipping the gatekeeper: S1P regulation of endothelial barrier function. | 2007 | Trends Immunol. | pmid:17276731 |
Liao JJ et al. | Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17442922 |
Choi CH et al. | Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | 2007 | Arch. Pharm. Res. | pmid:17489368 |
Donati C et al. | Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. | 2007 | Stem Cells | pmid:17464089 |
Naor MM et al. | Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences. | 2007 | J. Mol. Graph. Model. | pmid:17467317 |
Ito K et al. | Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17418101 |
Roztocil E et al. | Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation. | 2007 | J. Vasc. Surg. | pmid:18155002 |
Xia P | Letter by Xia regarding article, "High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor". | 2007 | Circulation | pmid:17420358 |
Kim DH et al. | Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. | 2007 | Arch. Pharm. Res. | pmid:17879749 |
Jacobson JR and Garcia JG | Novel therapies for microvascular permeability in sepsis. | 2007 | Curr Drug Targets | pmid:17430121 |
Kihara A et al. | Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. | 2007 | Prog. Lipid Res. | pmid:17449104 |
Samy ET et al. | Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17947634 |
Watterson KR et al. | Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. | 2007 | FASEB J. | pmid:17449719 |
Czeloth N et al. | Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen. | 2007 | J. Immunol. | pmid:17947659 |
Shin JH et al. | Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation. | 2007 | J. Korean Med. Sci. | pmid:17449940 |
Jongsma M et al. | Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17497135 |
Zabielski P et al. | Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17499747 |
Olivera A et al. | The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. | 2007 | Immunity | pmid:17346996 |
Catarzi S et al. | Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase. | 2007 | Biochim. Biophys. Acta | pmid:17349748 |
Park KS et al. | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17349972 |
Zhao M et al. | [The effects of sphingosine-1 1-phosphate (SIP) on the action potential and contractile in guinea pig ventricular myocardium]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171361 |
Togame H et al. | Development of a simple and robust assay to screen for inhibitors of sphingosine kinases. | 2007 | Assay Drug Dev Technol | pmid:17477830 |
Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
Murph M and Mills GB | Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. | 2007 | Expert Rev Mol Med | pmid:17935635 |
Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
Roviezzo F et al. | Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322125 |
Kajimoto T et al. | Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. | 2007 | Mol. Cell. Biol. | pmid:17325039 |
Nombela-Arrieta C et al. | A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. | 2007 | J. Exp. Med. | pmid:17325199 |
Osada M et al. | Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. | 2007 | J. Biochem. | pmid:17646176 |
Weigert A et al. | Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. | 2007 | Mol. Biol. Cell | pmid:17652460 |
Mulders AC et al. | Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. | 2007 | Auton Autacoid Pharmacol | pmid:18076478 |
Kimura A et al. | Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. | 2007 | Stem Cells | pmid:16990586 |
Schwab SR and Cyster JG | Finding a way out: lymphocyte egress from lymphoid organs. | 2007 | Nat. Immunol. | pmid:18026082 |
Lee YM et al. | A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991617 |
Leiber D et al. | Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16956968 |
Tani M et al. | Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space. | 2007 | Cell. Signal. | pmid:16963225 |
Hancke K et al. | Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. | 2007 | Fertil. Steril. | pmid:17081530 |