Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang F and Fishman DA | Lysophosphatidic acid and invasion. | 2009 | Cancer Treat. Res. | pmid:19763441 |
Kawamori T et al. | Role for sphingosine kinase 1 in colon carcinogenesis. | 2009 | FASEB J. | pmid:18824518 |
Rohatagi S et al. | Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator. | 2009 | J Clin Pharmacol | pmid:18948412 |
Satoh Y et al. | Regulation by sphingolipids of the fate of FRTL-5 cells. | 2009 | J. Biochem. | pmid:18953023 |
Michaelson LV et al. | Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. | 2009 | Plant Physiol. | pmid:18978071 |
Jo SK et al. | Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. | 2009 | Kidney Int. | pmid:18971925 |
Wang L and Dudek SM | Regulation of vascular permeability by sphingosine 1-phosphate. | 2009 | Microvasc. Res. | pmid:18973762 |
Sun X et al. | Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. | 2009 | Microvasc. Res. | pmid:19323978 |
Beech DJ et al. | TRPC channel lipid specificity and mechanisms of lipid regulation. | 2009 | Cell Calcium | pmid:19324410 |
Hayashi H et al. | FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19325137 |
Annabi B et al. | Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. | 2009 | Mol. Carcinog. | pmid:19326372 |
Boyce BF | Sphingosine-1 phosphate: a new player in osteoimmunology. | 2009 | Dev. Cell | pmid:19289077 |
Yamane D et al. | Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis. | 2009 | J. Biol. Chem. | pmid:19293152 |
Green DS et al. | Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. | 2009 | J. Virol. | pmid:19297493 |
Yu H et al. | Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration. | 2009 | Genes Cells | pmid:19371379 |
Milara J et al. | Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis. | 2009 | Eur. J. Pharmacol. | pmid:19285497 |
Huang YL et al. | Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells. | 2009 | J. Biochem. | pmid:19692429 |
Antoon JW et al. | Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. | 2009 | J. Med. Chem. | pmid:19694470 |
Zhao J et al. | Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement. | 2009 | Cell. Signal. | pmid:19755153 |
Crousillac S et al. | Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. | 2009 | J. Neurophysiol. | pmid:19776367 |
Igarashi J et al. | Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19710365 |
Stamer WD et al. | Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. | 2009 | Exp. Eye Res. | pmid:19715693 |
Li C et al. | Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. | 2009 | Am. J. Pathol. | pmid:19729475 |
Hait NC et al. | Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. | 2009 | Science | pmid:19729656 |
Czech B et al. | The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19720050 |
Mochizuki N | [Discovery of S1P transporter may uncover the unidentified S1P-regulated signal in circulation, immunity, and bone metabolism]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19764473 |
Zhao YD et al. | Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. | 2009 | Circ. Res. | pmid:19696411 |
Yamamura T | [Molecular target drug development for curing multiple sclerosis]. | 2009 | Brain Nerve | pmid:19697881 |
Ranty ML et al. | Ceramide production associated with retinal apoptosis after retinal detachment. | 2009 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:18958490 |
Young N et al. | Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. | 2009 | Mol. Cancer Res. | pmid:19147534 |
Weis N et al. | Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. | 2009 | Mol. Biol. Cell | pmid:19129475 |
Li MH et al. | S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. | 2009 | Cancer Lett. | pmid:19131156 |
Gérard A et al. | The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. | 2009 | Blood | pmid:19139083 |
Berdyshev EV et al. | FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. | 2009 | J. Biol. Chem. | pmid:19119142 |
Vogel P et al. | Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. | 2009 | PLoS ONE | pmid:19119317 |
Roztocil E et al. | Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration. | 2009 | Surgery | pmid:19081473 |
Evindar G et al. | Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19081720 |
Lagadari M et al. | Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. | 2009 | Int. J. Oncol. | pmid:19082500 |
Yonesu K et al. | Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog. | 2009 | Biochem. Pharmacol. | pmid:19150609 |
Frias MA et al. | Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. | 2009 | Cardiovasc. Res. | pmid:19151362 |
Liao JJ et al. | Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. | 2009 | FASEB J. | pmid:19158154 |
Jang C et al. | Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19112163 |
Bergelin N et al. | Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2. | 2009 | Endocrinology | pmid:19116345 |
Malchinkhuu E et al. | Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. | 2009 | Mol. Biol. Cell | pmid:19864456 |
Morris AJ et al. | Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation. | 2009 | Trends Cardiovasc. Med. | pmid:19818950 |
Tachikawa M et al. | Lysophospholipids enhance taurine release from rat retinal vascular endothelial cells under hypoosmotic stress. | 2009 | Microvasc. Res. | pmid:19804786 |
Kimber I et al. | Langerhans cell migration: not necessarily always at the center of the skin sensitization universe. | 2009 | J. Invest. Dermatol. | pmid:19603050 |
Pyne NJ et al. | New aspects of sphingosine 1-phosphate signaling in mammalian cells. | 2009 | Adv. Enzyme Regul. | pmid:19534035 |
Price MM et al. | Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. | 2009 | FASEB J. | pmid:19535686 |
Nixon GF | Sphingolipids in inflammation: pathological implications and potential therapeutic targets. | 2009 | Br. J. Pharmacol. | pmid:19563535 |
Taniguchi K et al. | Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. | 2009 | Cancer Sci. | pmid:19493272 |
Daum G et al. | Sphingosine 1-phosphate: a regulator of arterial lesions. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19592471 |
Jung ID et al. | FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. | 2009 | Cell. Signal. | pmid:19632319 |
Martin JL et al. | Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. | 2009 | J. Biol. Chem. | pmid:19633297 |
Trifilieff A et al. | Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19636535 |
Wacker BK et al. | Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. | 2009 | Stroke | pmid:19644058 |
Miranda GE et al. | Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19357361 |
Vessey DA et al. | Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19648253 |
Ohno Y et al. | Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization. | 2009 | Genes Cells | pmid:19619245 |
Florey O and Haskard DO | Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions. | 2009 | J. Immunol. | pmid:19620297 |
Weigert A et al. | Regulation of macrophage function by sphingosine-1-phosphate. | 2009 | Immunobiology | pmid:19625101 |
Rütti S et al. | Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. | 2009 | Endocrinology | pmid:19628574 |
Rapizzi E et al. | Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. | 2009 | Cell. Mol. Life Sci. | pmid:19662499 |
Haberberger RV et al. | Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness. | 2009 | J. Allergy Clin. Immunol. | pmid:19665772 |
Kim CH | Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. | 2009 | Immunol. Cell Biol. | pmid:19652661 |
Yin H et al. | Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. | 2009 | J. Biol. Chem. | pmid:19286662 |
Ader I et al. | When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | 2009 | Cancer Res. | pmid:19383898 |
Greenspon J et al. | Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. | 2009 | Dig. Dis. Sci. | pmid:18654850 |
Malemud CJ | The discovery of novel experimental therapies for inflammatory arthritis. | 2009 | Mediators Inflamm. | pmid:20339519 |
Xie B et al. | Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization. | 2009 | J. Cell. Physiol. | pmid:18781584 |
Wetter JA et al. | Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation. | 2009 | J Biomol Screen | pmid:19726785 |
Pyne S et al. | Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. | 2009 | Cell. Signal. | pmid:18768158 |
Zebol JR et al. | The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. | 2009 | Int. J. Biochem. Cell Biol. | pmid:18775504 |
Foster DJ et al. | Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells. | 2009 | J. Neurochem. | pmid:19012745 |
Okajima F et al. | Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I. | 2009 | Endocr. J. | pmid:18753704 |
Jenne CN et al. | T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. | 2009 | J. Exp. Med. | pmid:19808259 |
Snider AJ et al. | A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. | 2009 | FASEB J. | pmid:18815359 |
Long DA and Price KL | Sphingosine kinase-1: a potential mediator of renal fibrosis. | 2009 | Kidney Int. | pmid:19789541 |
Heo K et al. | Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells. | 2009 | BMB Rep | pmid:19874715 |
Zhao M et al. | [The effects of Sphing-1-phosphate(S1P) on the potassium channel of the ventricular myocytes]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21186617 |
Jongsma M et al. | Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). | 2009 | Br. J. Pharmacol. | pmid:19309361 |
Garcia JG | Concepts in microvascular endothelial barrier regulation in health and disease. | 2009 | Microvasc. Res. | pmid:19232241 |
Igarashi J and Michel T | Sphingosine-1-phosphate and modulation of vascular tone. | 2009 | Cardiovasc. Res. | pmid:19233865 |
Sattler K and Levkau B | Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. | 2009 | Cardiovasc. Res. | pmid:19233866 |
Ishii M et al. | Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. | 2009 | Nature | pmid:19204730 |
Zhang ZY et al. | FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. | 2009 | Neuropathol. Appl. Neurobiol. | pmid:19207263 |
Gillies L et al. | The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. | 2009 | Cell. Signal. | pmid:19211033 |
Hla T and Im DS | Cell biology. The ABCs of lipophile transport. | 2009 | Science | pmid:19213902 |
Thathiah A et al. | The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. | 2009 | Science | pmid:19213921 |
Gaengel K et al. | Endothelial-mural cell signaling in vascular development and angiogenesis. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19164813 |
Benamer N et al. | Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. | 2009 | J. Mol. Cell. Cardiol. | pmid:19166858 |
Scherer M et al. | High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. | 2009 | Clin. Chem. | pmid:19325012 |
Wadgaonkar R et al. | Differential regulation of sphingosine kinases 1 and 2 in lung injury. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19168577 |
Reines I et al. | Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. | 2009 | J. Invest. Dermatol. | pmid:19194476 |
Kim RH et al. | Export and functions of sphingosine-1-phosphate. | 2009 | Biochim. Biophys. Acta | pmid:19268560 |
Shimizu M et al. | Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship. | 2009 | J. Pharmacol. Sci. | pmid:19276615 |
Limaye V et al. | Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. | 2009 | Cell. Mol. Biol. Lett. | pmid:19238330 |
Limaye V et al. | The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. | 2009 | Cell. Mol. Biol. Lett. | pmid:19238331 |
Schnitzer SE et al. | Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. | 2009 | Mol. Cancer Res. | pmid:19240180 |
Xu Y et al. | Lipid generation and signaling in ovarian cancer. | 2009 | Cancer Treat. Res. | pmid:19763440 |