Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Setoguchi R | IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. | 2016 | Int. Immunol. | pmid:26857736 |
Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
Luo B et al. | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. | 2016 | Immunity | pmid:26872696 |
Ko P et al. | Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. | 2016 | Sci Rep | pmid:26877098 |
Tang X et al. | Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. | 2016 | J. Lipid Res. | pmid:26884614 |
Chumanevich A et al. | Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. | 2016 | Mediators Inflamm. | pmid:26884643 |
Uranbileg B et al. | Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. | 2016 | PLoS ONE | pmid:26886371 |
Bien-Möller S et al. | Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. | 2016 | Oncotarget | pmid:26887055 |
Medina CB and Ravichandran KS | Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. | 2016 | Cell Death Differ. | pmid:26891690 |
Park K et al. | ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26903652 |
Yang Y et al. | Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. | 2016 | Neurochem. Int. | pmid:26921668 |
Liu W et al. | Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. | 2016 | Eur. J. Pharmacol. | pmid:26921757 |
Watterson SH et al. | Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. | 2016 | J. Med. Chem. | pmid:26924461 |
Grammatikos G et al. | Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | 2016 | Oncotarget | pmid:26933996 |
Kalhori V et al. | FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. | 2016 | Endocr. Relat. Cancer | pmid:26935838 |
Guerrero M et al. | Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). | 2016 | Expert Opin Ther Pat | pmid:26947494 |
Jin J et al. | Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. | 2016 | Sci Rep | pmid:26948042 |
Chen C et al. | Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. | 2016 | Mol. Cell. Endocrinol. | pmid:26948947 |
Vito CD et al. | Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. | 2016 | Platelets | pmid:26950429 |
Chawla S et al. | S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. | 2016 | IUBMB Life | pmid:26959531 |
Brinck JW et al. | Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. | 2016 | Arterioscler. Thromb. Vasc. Biol. | pmid:26966278 |
Aoki M et al. | Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. | 2016 | Mediators Inflamm. | pmid:26966342 |
Pyne S et al. | Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. | 2016 | Prog. Lipid Res. | pmid:26970273 |
Bae SJ et al. | The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. | 2016 | Osteoporos Int | pmid:26984570 |
Frej C et al. | Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. | 2016 | J. Cell. Mol. Med. | pmid:26990127 |
Cheng JC et al. | Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. | 2016 | Cell. Signal. | pmid:26994820 |
Lv M et al. | Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. | 2016 | Inflamm. Res. | pmid:27002656 |
Zhang L et al. | Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. | 2016 | Microcirculation | pmid:27015105 |
Adams DR et al. | Sphingosine Kinases: Emerging Structure-Function Insights. | 2016 | Trends Biochem. Sci. | pmid:27021309 |
Guo J et al. | Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). | 2016 | Bioorg. Med. Chem. Lett. | pmid:27055941 |
Resop RS et al. | Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human TÂ cells from the thymus to the periphery. | 2016 | J. Allergy Clin. Immunol. | pmid:27056271 |
Koresawa R et al. | Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. | 2016 | Br. J. Haematol. | pmid:27061580 |
Anbazhagan AN et al. | Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27079615 |
Castaldi A et al. | Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. | 2016 | Cell. Signal. | pmid:27094722 |
Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
Li N and Zhang F | Implication of sphingosin-1-phosphate in cardiovascular regulation. | 2016 | Front Biosci (Landmark Ed) | pmid:27100508 |
Crespo I et al. | Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. | 2016 | J. Pineal Res. | pmid:27101794 |
Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
Barnawi J et al. | Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. | 2016 | COPD | pmid:27144721 |
Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
Tafelmeier M et al. | Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27163393 |
Ohtoyo M et al. | Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. | 2016 | Cell Chem Biol | pmid:27185637 |
Zhang XE et al. | Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. | 2016 | PLoS ONE | pmid:27187066 |
Nagahashi M et al. | Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. | 2016 | J Mammary Gland Biol Neoplasia | pmid:27194029 |
Sauvé M et al. | Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. | 2016 | Diabetes | pmid:27207546 |
Versmissen J et al. | Familial hypercholesterolaemia: cholesterol efflux and coronary disease. | 2016 | Eur. J. Clin. Invest. | pmid:27208892 |
Gudipaty SA and Rosenblatt J | Epithelial cell extrusion: Pathways and pathologies. | 2017 | Semin. Cell Dev. Biol. | pmid:27212253 |
Marfia G et al. | The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. | 2016 | Stem Cells Dev. | pmid:27217090 |
Bao XH et al. | [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. | 2016 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:27220580 |
Mirzaian M et al. | Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. | 2016 | Clin. Chim. Acta | pmid:27221202 |
Hollands A et al. | Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. | 2016 | J. Biol. Chem. | pmid:27226531 |
Puli MR et al. | Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. | 2016 | Planta | pmid:27233507 |
Juif PE et al. | Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. | 2016 | Expert Opin Drug Metab Toxicol | pmid:27249325 |
Gharbaran R | Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. | 2016 | Tumour Biol. | pmid:27317256 |
Cantalupo A and Di Lorenzo A | S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27317800 |
Yang Z et al. | TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. | 2016 | Pharmacol. Res. | pmid:27317945 |
Tsai HC and Han MH | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. | 2016 | Drugs | pmid:27318702 |
Pierucci F et al. | Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. | 2017 | Arch. Toxicol. | pmid:27318803 |
Chakrabarti SS et al. | Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. | 2016 | Curr Alzheimer Res | pmid:27335046 |
Hernández-Coronado CG et al. | Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. | 2016 | Gen. Comp. Endocrinol. | pmid:27342378 |
Harijith A et al. | Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27343196 |
Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
Rodvold JJ and Zanetti M | Tumor microenvironment on the move and the Aselli connection. | 2016 | Sci Signal | pmid:27353363 |
Jung M et al. | Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. | 2016 | Sci Signal | pmid:27353364 |
Tiper IV et al. | Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. | 2016 | Pathog Dis | pmid:27354294 |
Sanagawa A et al. | Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. | 2016 | Mol Med Rep | pmid:27357063 |
Egom EE et al. | Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. | 2016 | Mol. Cell. Biochem. | pmid:27372350 |
Liu X et al. | ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. | 2016 | J. Physiol. Biochem. | pmid:27377933 |
Tong S et al. | Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. | 2016 | J. Biol. Chem. | pmid:27405756 |
Adamiak M et al. | Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. | 2016 | Cell Transplant | pmid:27412411 |
Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
Poissonnier A et al. | CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. | 2016 | Immunity | pmid:27438772 |
Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
Evangelisti C et al. | Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. | 2016 | Leukemia | pmid:27461062 |
Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
Viswanathan P et al. | Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27473658 |
Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
Vogt D and Stark H | Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. | 2017 | Med Res Rev | pmid:27480072 |
Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
Al Alam N and Kreydiyyeh SI | FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. | 2016 | Biochem. Cell Biol. | pmid:27501354 |
Gstalder C et al. | FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. | 2016 | Mol. Cancer Ther. | pmid:27507852 |
Harris CM et al. | Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27519818 |
Van Veldhoven PP et al. | A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. | 1989 | J. Lipid Res. | pmid:2754341 |
Chang N et al. | HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. | 2017 | J. Mol. Med. | pmid:27543493 |
Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
Sasset L et al. | Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. | 2016 | Trends Endocrinol. Metab. | pmid:27562337 |
Nagahashi M et al. | High levels of sphingolipids in human breast cancer. | 2016 | J. Surg. Res. | pmid:27565080 |
Thieme M et al. | Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. | 2017 | Exp. Dermatol. | pmid:27574180 |
Machida T et al. | Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. | 2016 | J. Pharmacol. Sci. | pmid:27581589 |
Gazit SL et al. | Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. | 2016 | Circ. Res. | pmid:27582371 |
Hamidi Shishavan M et al. | Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. | 2016 | PLoS ONE | pmid:27583547 |
Neubauer HA et al. | An oncogenic role for sphingosine kinase 2. | 2016 | Oncotarget | pmid:27588496 |
Chen W et al. | Sphingosine 1-phosphate in metabolic syndrome (Review). | 2016 | Int. J. Mol. Med. | pmid:27600830 |
Higashi K et al. | Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. | 2016 | Bone | pmid:27612439 |
Pruvost R and Le Stunff H | [Sphingosine kinase-1: role in non alcoholic fatty liver disease]. | Med Sci (Paris) | pmid:27615179 |