Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gueguen G et al. | Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. | 1999 | Biochemistry | pmid:10387090 |
| Li S et al. | Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes. | 1999 | J. Lipid Res. | pmid:9869657 |
| Liu CH et al. | Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. | 1999 | Mol. Biol. Cell | pmid:10198065 |
| Watanabe Y and Akaike T | Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. | 1999 | J. Cell. Physiol. | pmid:10082131 |
| Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
| Wang F et al. | Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate. | 1999 | Exp. Cell Res. | pmid:10047444 |
| Goetzl EJ et al. | Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. | 1999 | Cancer Res. | pmid:10493533 |
| Goetzl EJ et al. | Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. | 1999 | Cancer Res. | pmid:10537322 |
| Lee OH et al. | Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10544002 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| Meacci E et al. | Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C. | 1999 | FEBS Lett. | pmid:10471775 |
| Windh RT et al. | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. | 1999 | J. Biol. Chem. | pmid:10488065 |
| Banno Y et al. | Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. | 1999 | J. Biol. Chem. | pmid:10488069 |
| Kozawa O et al. | Sphingosine 1-phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts. | 1999 | J. Bone Miner. Res. | pmid:10491224 |
| Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
| Meyer zu Heringdorf D et al. | Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor. | 1999 | FEBS Lett. | pmid:10567700 |
| Stewart CE et al. | Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis. | 1999 | Exp. Cell Res. | pmid:10413587 |
| Sabbadini RA et al. | The role of sphingolipids in the control of skeletal muscle function: a review. | 1999 | Ital J Neurol Sci | pmid:10937863 |
| Pyne S et al. | Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917611 |
| Goetzl EJ and An S | A subfamily of G protein-coupled cellular receptors for lysophospholipids and lysosphingolipids. | 1999 | Adv. Exp. Med. Biol. | pmid:10667339 |
| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Wang F et al. | Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. | 1999 | Cancer Res. | pmid:10626811 |
| Wang F et al. | Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. | 1999 | J. Biol. Chem. | pmid:10585401 |
| Denisova NA et al. | The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10641723 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Zhang Q et al. | Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. | 1999 | Blood | pmid:10216094 |
| Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
| Vasta V et al. | Effects of sphingosine 1-phosphate and bradykinin on phospholipid signalling in human epithelial A549 cells. | 1998 | Biochem. Soc. Trans. | pmid:9765948 |
| Edsall LC et al. | N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. | 1998 | Biochemistry | pmid:9737868 |
| Spiegel S et al. | Sphingosine-1-phosphate in cell growth and cell death. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668339 |
| Igarashi Y | Sphingosine-1-phosphate as an intercellular signaling molecule. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668340 |
| Stam JC et al. | Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. | 1998 | EMBO J. | pmid:9670021 |
| Himmel HM et al. | Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. | 1998 | Mol. Pharmacol. | pmid:9584212 |
| Yatomi Y et al. | [Signal transduction related to sphingosine 1-phosphate]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9883680 |
| Lanterman MM and Saba JD | Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. | 1998 | Biochem. J. | pmid:9601083 |
| Cuvillier O et al. | Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. | 1998 | J. Biol. Chem. | pmid:9446602 |
| Okamoto H et al. | EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. | 1998 | J. Biol. Chem. | pmid:9765227 |
| Takeda H et al. | Sphingomyelinase and ceramide inhibit formation of F-actin ring in and bone resorption by rabbit mature osteoclasts. | 1998 | FEBS Lett. | pmid:9490019 |
| Kovács P et al. | The effects of ceramide and its analogues on the secretion of the mucocyst content of Tetrahymena. | 1998 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:9763202 |
| Nagiec MM et al. | The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. | 1998 | J. Biol. Chem. | pmid:9677363 |
| Van Brocklyn JR et al. | Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. | 1998 | J. Cell Biol. | pmid:9660876 |
| Mandala SM et al. | Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9419344 |
| Guo C et al. | Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate. | 1998 | Eur. J. Biochem. | pmid:9826186 |
| Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Noh SJ et al. | Different signaling pathway between sphingosine-1-phosphate and lysophosphatidic acid in Xenopus oocytes: functional coupling of the sphingosine-1-phosphate receptor to PLC-xbeta in Xenopus oocytes. | 1998 | J. Cell. Physiol. | pmid:9648929 |
| van Echten-Deckert G et al. | Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. | 1998 | J. Biol. Chem. | pmid:9722598 |
| Melendez A et al. | FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. | 1998 | J. Biol. Chem. | pmid:9545263 |
| Spiegel S et al. | Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. | 1998 | Biochemistry Mosc. | pmid:9526097 |
| Hamada K et al. | Involvement of Mac-1-mediated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9535736 |