Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Farnoud AM et al. | The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. | 2015 | Infect. Immun. | pmid:25895971 |
Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
Pulli I et al. | A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. | 2015 | Biochim. Biophys. Acta | pmid:25892494 |
Moolenaar WH | Introduction to the ECR special issue on lysophospholipids in biology. | 2015 | Exp. Cell Res. | pmid:25746723 |
Hsu CK et al. | Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. | 2015 | J. Cell. Physiol. | pmid:25201048 |
Lin CC et al. | Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. | 2015 | PLoS ONE | pmid:25734900 |
Zhang DD et al. | Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. | 2015 | Biol. Chem. | pmid:25720064 |
Schröder M et al. | Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. | 2015 | Biol. Chem. | pmid:25720062 |
Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
Pyne NJ and Kolesnick RN | The life and work of Dr. Robert Bittman (1942-2014). | 2015 | Biol. Chem. | pmid:25473803 |
Hashimoto Y et al. | Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. | 2015 | Mol. Cell. Biochem. | pmid:25445169 |
Sano N et al. | New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. | 2015 | World J. Gastroenterol. | pmid:26668502 |
Wang K et al. | Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. | 2015 | PLoS Genet. | pmid:26474409 |
Sutter I et al. | Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. | 2015 | Atherosclerosis | pmid:26093887 |
Le Bihan O et al. | Visualization of adherent cell monolayers by cryo-electron microscopy: A snapshot of endothelial adherens junctions. | 2015 | J. Struct. Biol. | pmid:26470813 |
Cantalupo A et al. | Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. | 2015 | Nat. Med. | pmid:26301690 |
Adamiak M et al. | Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. | 2015 | Oncotarget | pmid:26299919 |
Marycz K et al. | The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells--new opportunities in regenerative medicine. | 2015 | Cell. Mol. Biol. Lett. | pmid:26110483 |
Chen MH et al. | Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. | 2015 | Oncotarget | pmid:26090720 |
El-Najjar N et al. | Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. | 2015 | PLoS ONE | pmid:26466367 |