Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |
Hojjati MR et al. | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | 2005 | J. Biol. Chem. | pmid:15590644 |
Davis MD et al. | Sphingosine 1-phosphate analogs as receptor antagonists. | 2005 | J. Biol. Chem. | pmid:15590668 |
Lee MS et al. | Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590895 |
Kihara A et al. | [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16146193 |
Fieger CB et al. | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | 2005 | FASEB J. | pmid:16148028 |
Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
Schwab SR et al. | Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. | 2005 | Science | pmid:16151014 |
Shida D et al. | Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15649431 |
Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
Danieli-Betto D et al. | Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15659717 |
Pettus BJ et al. | The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. | 2005 | Mol. Pharmacol. | pmid:15900018 |
Katsuma S et al. | Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. | 2005 | FEBS Lett. | pmid:15862293 |
Johnstone ED et al. | Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | 2005 | J. Lipid Res. | pmid:15995175 |
Rosen H and Goetzl EJ | Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | 2005 | Nat. Rev. Immunol. | pmid:15999095 |
Karliner JS | Off the shelf but not mass produced. | 2005 | Chem. Biol. | pmid:15975506 |
Jo E et al. | S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. | 2005 | Chem. Biol. | pmid:15975516 |
Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
Maupas-Schwalm F et al. | The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. | 2004 | FASEB J. | pmid:15231724 |
Fujita T et al. | Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. | 2004 | Biochem. J. | pmid:15193146 |
Brinkmann V et al. | FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | 2004 | Am. J. Transplant. | pmid:15196057 |
Im DS et al. | Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. | 2004 | J. Pharmacol. Sci. | pmid:15215654 |
Pandey S and Assmann SM | The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. | 2004 | Plant Cell | pmid:15155892 |
Taha TA et al. | Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. | 2004 | Biochim. Biophys. Acta | pmid:15158755 |
Duong CQ et al. | Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. | 2004 | Biochim. Biophys. Acta | pmid:15158762 |
Zhou H and Murthy KS | Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075212 |
Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
Hung RJ et al. | Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075215 |
Wang W et al. | Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. | 2004 | FASEB J. | pmid:15084513 |
Dudek SM et al. | Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. | 2004 | J. Biol. Chem. | pmid:15056655 |
Saba JD and Hla T | Point-counterpoint of sphingosine 1-phosphate metabolism. | 2004 | Circ. Res. | pmid:15059942 |
Miura Y et al. | Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. | 2004 | J. Thromb. Haemost. | pmid:15140149 |
Garg SK et al. | Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. | 2004 | J. Infect. Dis. | pmid:15143482 |
Hale JJ et al. | Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15149705 |
Oshima Y et al. | Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization. | 2004 | J. Cell. Physiol. | pmid:15095287 |
Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
Peng X et al. | Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15020292 |
Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
Gräler MH and Goetzl EJ | The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. | 2004 | FASEB J. | pmid:14715694 |
Ohmori T et al. | Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2004 | J. Thromb. Haemost. | pmid:14717991 |
Renkl A et al. | Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. | 2004 | Int. J. Mol. Med. | pmid:14719124 |
Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
Shimamura K et al. | Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:14975703 |
Anliker B and Chun J | Cell surface receptors in lysophospholipid signaling. | 2004 | Semin. Cell Dev. Biol. | pmid:15271291 |
Pyne S et al. | Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. | 2004 | Semin. Cell Dev. Biol. | pmid:15271294 |
Tokumura A | Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. | 2004 | J. Cell. Biochem. | pmid:15258912 |
Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
Barber SC et al. | S1P and LPA trigger Schwann cell actin changes and migration. | 2004 | Eur. J. Neurosci. | pmid:15217370 |
Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
Yatomi Y et al. | Sphingosine 1-phosphate breakdown in platelets. | 2004 | J. Biochem. | pmid:15625319 |
Galaria II et al. | Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. | 2004 | J. Surg. Res. | pmid:15555614 |
Shida D et al. | Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. | 2004 | FEBS Lett. | pmid:15556605 |
Langlois S et al. | Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. | 2004 | Blood | pmid:15070679 |
Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
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Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
Allende ML et al. | Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. | 2004 | J. Biol. Chem. | pmid:15459201 |
Yamanaka M et al. | Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. | 2004 | J. Biol. Chem. | pmid:15485866 |
Alewijnse AE et al. | Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. | 2004 | Br. J. Pharmacol. | pmid:15504747 |
Bhattacharya J | Lung injury: sphingosine-1-phosphate to the rescue. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15504814 |
Hedemann J et al. | Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | 2004 | Auton Autacoid Pharmacol | pmid:15541015 |
Kumar A et al. | Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. | 2004 | Cell Motil. Cytoskeleton | pmid:15476260 |
Sun C and Bittman R | An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. | 2004 | J. Org. Chem. | pmid:15497998 |
Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
Ozbay T et al. | ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. | 2004 | Endocr. Res. | pmid:15666826 |
Mo FM et al. | Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. | 2004 | Eur. J. Pharmacol. | pmid:15063151 |
Butler J et al. | Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165029 |
Chae SS et al. | Constitutive expression of the S1P1 receptor in adult tissues. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165038 |
Geoffroy K et al. | Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids. | 2004 | J. Biol. Chem. | pmid:15184394 |
Xin C et al. | Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. | 2004 | J. Biol. Chem. | pmid:15192102 |
Baudhuin LM et al. | S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). | 2004 | FASEB J. | pmid:14657000 |
Otala M et al. | Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. | 2004 | Biol. Reprod. | pmid:14613902 |
Kelley GG et al. | Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | 2004 | Biochem. J. | pmid:14567755 |
Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
Gonzalez E et al. | Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | 2004 | J. Biol. Chem. | pmid:15292187 |
Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
McVerry BJ et al. | Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15282202 |
Ogretmen B and Hannun YA | Biologically active sphingolipids in cancer pathogenesis and treatment. | 2004 | Nat. Rev. Cancer | pmid:15286740 |
Sutphen R et al. | Lysophospholipids are potential biomarkers of ovarian cancer. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15247129 |
Sauer B et al. | Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. | 2004 | J. Biol. Chem. | pmid:15247277 |
Roviezzo F et al. | Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15254297 |
Hla T | Physiological and pathological actions of sphingosine 1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271296 |
Payne SG et al. | Modulation of adaptive immune responses by sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271297 |
Oskouian B and Saba JD | Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271298 |
Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |