| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Fabry Disease | D000795 | 4 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Le Stunff H et al. | Generation and metabolism of bioactive sphingosine-1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258913 |
| Muehlich S et al. | Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets. | 2004 | Atherosclerosis | pmid:15262182 |
| Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
| Melendez AJ and Ibrahim FB | Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis. | 2004 | J. Immunol. | pmid:15265887 |
| Anliker B and Chun J | Cell surface receptors in lysophospholipid signaling. | 2004 | Semin. Cell Dev. Biol. | pmid:15271291 |
| Pyne S et al. | Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases. | 2004 | Semin. Cell Dev. Biol. | pmid:15271294 |
| Hla T | Physiological and pathological actions of sphingosine 1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271296 |
| Payne SG et al. | Modulation of adaptive immune responses by sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271297 |
| Oskouian B and Saba JD | Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271298 |
| Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
| Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |
| McVerry BJ et al. | Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15282202 |
| Ogretmen B and Hannun YA | Biologically active sphingolipids in cancer pathogenesis and treatment. | 2004 | Nat. Rev. Cancer | pmid:15286740 |
| Gonzalez E et al. | Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | 2004 | J. Biol. Chem. | pmid:15292187 |
| Lockman K et al. | Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors. | 2004 | J. Biol. Chem. | pmid:15292266 |
| Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
| Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
| Holdsworth G et al. | A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. | 2004 | BMC Biochem. | pmid:15298705 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
| Panetti TS et al. | Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | 2004 | J. Thromb. Haemost. | pmid:15333043 |
| Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
| Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
| Grey A et al. | Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate. | 2004 | Calcif. Tissue Int. | pmid:15354862 |
| Argraves KM et al. | Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. | 2004 | J. Biol. Chem. | pmid:15377653 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Allende ML et al. | Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. | 2004 | J. Biol. Chem. | pmid:15459201 |
| Liu S et al. | Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. | 2004 | J. Biol. Chem. | pmid:15466414 |
| Xin C et al. | Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15466446 |
| Birukov KG et al. | Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | 2004 | Circ. Res. | pmid:15472119 |
| Kumar A et al. | Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. | 2004 | Cell Motil. Cytoskeleton | pmid:15476260 |
| Yamanaka M et al. | Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. | 2004 | J. Biol. Chem. | pmid:15485866 |
| McVerry BJ and Garcia JG | In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. | 2005 | Cell. Signal. | pmid:15494205 |
| Waters CM et al. | c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | 2005 | Cell. Signal. | pmid:15494217 |
| Sun C and Bittman R | An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. | 2004 | J. Org. Chem. | pmid:15497998 |
| Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
| Nakamura H et al. | Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. | 2004 | Biochem. Pharmacol. | pmid:15498509 |
| Alewijnse AE et al. | Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. | 2004 | Br. J. Pharmacol. | pmid:15504747 |
| Bhattacharya J | Lung injury: sphingosine-1-phosphate to the rescue. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15504814 |
| Itagaki K et al. | Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. | 2005 | J. Leukoc. Biol. | pmid:15522918 |
| Hedemann J et al. | Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | 2004 | Auton Autacoid Pharmacol | pmid:15541015 |
| Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
| Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
| Galaria II et al. | Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. | 2004 | J. Surg. Res. | pmid:15555614 |
| Shida D et al. | Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. | 2004 | FEBS Lett. | pmid:15556605 |
| Watterson KR et al. | The role of sphingosine-1-phosphate in smooth muscle contraction. | 2005 | Cell. Signal. | pmid:15567060 |
| Elices MJ | Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | 2004 | Curr Opin Investig Drugs | pmid:15573862 |
| Lee C et al. | Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition. | 2004 | J Trauma | pmid:15580017 |
| Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
| Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |