| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Fabry Disease | D000795 | 4 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
| Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
| Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
| Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
| Tanaka K et al. | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. | 2014 | Clin. Exp. Immunol. | pmid:24028747 |
| Anderson G and Maes M | Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. | 2014 | CNS Neurol Disord Drug Targets | pmid:24040808 |
| Waeber C and Walther T | Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction. | 2014 | Circ. J. | pmid:24632793 |
| Snider AJ et al. | Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. | 2014 | PLoS ONE | pmid:25460165 |
| Nakanaga K et al. | Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. | 2014 | J. Biochem. | pmid:24451492 |
| Kim YI et al. | An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. | 2014 | Mol. Cell. Biol. | pmid:25312644 |
| Miller DS | Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24385389 |
| Dai L et al. | Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? | 2014 | Cancer Invest. | pmid:24499107 |
| Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
| Takeshita E et al. | Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24486543 |
| Kamiya T et al. | Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. | 2014 | Exp. Eye Res. | pmid:24486793 |
| Plano D et al. | Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. | 2014 | J. Med. Chem. | pmid:24471412 |
| Nakamura H and Murayama T | Role of sphingolipids in arachidonic acid metabolism. | 2014 | J. Pharmacol. Sci. | pmid:24599139 |
| Guo S et al. | Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. | 2014 | Biochim. Biophys. Acta | pmid:24603322 |
| Lepletier A et al. | Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. | 2014 | PLoS Negl Trop Dis | pmid:25330249 |
| Bradley E et al. | Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. | 2014 | PLoS ONE | pmid:25330231 |
| Xu H et al. | Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. | 2014 | Circ. J. | pmid:25319164 |
| Fukui H et al. | S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. | 2014 | Dev. Cell | pmid:25313964 |
| Obinata H et al. | Individual variation of human S1Pâ‚ coding sequence leads to heterogeneity in receptor function and drug interactions. | 2014 | J. Lipid Res. | pmid:25293589 |
| Fernández-Pisonero I et al. | Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells. | 2014 | PLoS ONE | pmid:25275309 |
| Kim ES et al. | Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. | 2014 | Oncogene | pmid:23955082 |
| St John AL et al. | S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. | 2014 | Immunity | pmid:25238098 |
| Davis KM and Isberg RR | Plague's partners in crime. | 2014 | Immunity | pmid:25238090 |
| Bi Y et al. | Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. | 2014 | Am. J. Pathol. | pmid:25111230 |
| Ishitsuka A et al. | FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. | 2014 | Int. J. Mol. Med. | pmid:25109763 |
| Xiong H et al. | SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. | 2014 | Oncol. Rep. | pmid:25109605 |
| Rolin J and Maghazachi AA | Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. | 2014 | J. Leukoc. Biol. | pmid:24493826 |
| Zhao X et al. | Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. | 2014 | J. Mol. Cell. Cardiol. | pmid:25106095 |
| Li MH et al. | Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. | 2014 | J. Pediatr. Surg. | pmid:25092091 |
| Awojoodu AO et al. | Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. | 2014 | Blood | pmid:25075126 |
| Tarbell JM et al. | Mechanosensing at the vascular interface. | 2014 | Annu Rev Biomed Eng | pmid:24905872 |
| Potì F et al. | Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). | 2014 | Cardiovasc. Res. | pmid:24891400 |
| Chawla S et al. | Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. | 2014 | PLoS ONE | pmid:24887065 |
| Janes K et al. | The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. | 2014 | J. Biol. Chem. | pmid:24876379 |
| Yan W et al. | Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. | 2014 | J. Mol. Cell. Cardiol. | pmid:24852843 |
| Sheridan GK and Dev KK | Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. | 2014 | Sci Rep | pmid:24851861 |
| Smyth SS et al. | Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24482375 |
| Takabe K and Spiegel S | Export of sphingosine-1-phosphate and cancer progression. | 2014 | J. Lipid Res. | pmid:24474820 |
| Ishizawa S et al. | Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor. | 2014 | Clin. Exp. Nephrol. | pmid:24463961 |
| Couttas TA et al. | Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. | 2014 | Acta Neuropathol Commun | pmid:24456642 |
| Gassowska M et al. | Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. | 2014 | Neurochem. Res. | pmid:24452756 |
| Fujii K et al. | Sphingosine 1-phosphate increases an intracellular Ca(2+) concentration via S1P3 receptor in cultured vascular smooth muscle cells. | 2014 | J. Pharm. Pharmacol. | pmid:24450400 |
| Abu El-Asrar AM et al. | Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. | 2014 | Lipids Health Dis | pmid:25496321 |
| Jensen T et al. | The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25442311 |
| Ye C et al. | Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24633425 |
| Pyszko J and Strosznajder JB | Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | 2014 | Mol. Neurobiol. | pmid:24399507 |