Shida D et al. |
Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. |
2004 |
FEBS Lett. |
pmid:15556605
|
Yatomi Y et al. |
Distribution of sphingosine 1-phosphate, a bioactive sphingolipid, in rat tissues. |
1997 |
FEBS Lett. |
pmid:9119058
|
Alemany R et al. |
Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. |
2001 |
FEBS Lett. |
pmid:11741596
|
Nakahara T et al. |
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. |
2012 |
Fertil. Steril. |
pmid:22763095
|
Meng Y et al. |
Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. |
2014 |
Fertil. Steril. |
pmid:24993801
|
Kaya H et al. |
Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? |
2008 |
Fertil. Steril. |
pmid:17517398
|
Santulli P et al. |
Sphingosine pathway deregulation in endometriotic tissues. |
2012 |
Fertil. Steril. |
pmid:22277765
|
Hancke K et al. |
Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. |
2007 |
Fertil. Steril. |
pmid:17081530
|
Jesko H et al. |
Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. |
2014 |
Folia Neuropathol |
pmid:24729344
|
Riley RT et al. |
A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. |
2015 |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess |
pmid:25833119
|
Barthomeuf C |
Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols. |
2007 |
Free Radic. Biol. Med. |
pmid:17189837
|
Barthomeuf C et al. |
Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. |
2006 |
Free Radic. Biol. Med. |
pmid:16458188
|
Camaré C et al. |
The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. |
2016 |
Free Radic. Biol. Med. |
pmid:26855418
|
Lafargue A et al. |
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. |
2017 |
Free Radic. Biol. Med. |
pmid:28431961
|
Denisova NA et al. |
The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. |
1999 |
Free Radic. Biol. Med. |
pmid:10641723
|
Soares R and Azevedo I |
Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? |
2007 |
Free Radic. Biol. Med. |
pmid:17189836
|
Chen T et al. |
Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
2017 |
Front Biosci (Landmark Ed) |
pmid:27814635
|
Li N and Zhang F |
Implication of sphingosin-1-phosphate in cardiovascular regulation. |
2016 |
Front Biosci (Landmark Ed) |
pmid:27100508
|
Schmidt KG et al. |
Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. |
2017 |
Front Immunol |
pmid:29033951
|
Tan SY et al. |
Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines. |
2007 |
Front. Biosci. |
pmid:17127411
|
Ponnusamy S et al. |
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. |
2010 |
Future Oncol |
pmid:21062159
|
Alvero AB et al. |
Anti-tumor activity of phenoxodiol: from bench to clinic. |
2008 |
Future Oncol |
pmid:18684059
|
Ikeda H et al. |
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. |
2003 |
Gastroenterology |
pmid:12557151
|
Abraham C et al. |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
pmid:27780712
|
King A et al. |
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
2017 |
Gastroenterology |
pmid:28363640
|
Hernández-Coronado CG et al. |
Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. |
2016 |
Gen. Comp. Endocrinol. |
pmid:27342378
|
Zhang G et al. |
Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. |
1999 |
Gene |
pmid:9931453
|
Chandru H and Boggaram V |
The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. |
2007 |
Gene |
pmid:17306937
|
Deutsch G et al. |
Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
2016 |
Gene |
pmid:26707209
|
Renault AD et al. |
Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. |
2002 |
Gene Expr. Patterns |
pmid:12617823
|
Yu H et al. |
Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration. |
2009 |
Genes Cells |
pmid:19371379
|
Katsuma S et al. |
Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. |
2002 |
Genes Cells |
pmid:12485162
|
Kohno T et al. |
Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. |
2003 |
Genes Cells |
pmid:12875654
|
Kohno T and Igarashi Y |
Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P. |
2008 |
Genes Cells |
pmid:18513330
|
Ohno Y et al. |
Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization. |
2009 |
Genes Cells |
pmid:19619245
|
Kariya Y et al. |
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. |
2005 |
Genes Cells |
pmid:15938718
|
Naetzker S et al. |
Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. |
2006 |
Genes Cells |
pmid:16483315
|
Yu H et al. |
Effect of sphingosine-1-phosphate and myoblast transplantation on rat acute myocardial infarction. |
2015 |
Genet. Mol. Res. |
pmid:26535699
|
Monier A et al. |
Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus. |
2009 |
Genome Res. |
pmid:19451591
|
Espinosa Cervantes R |
[Sphingolipids in embryonic implantation]. |
2009 |
Ginecol Obstet Mex |
pmid:19899433
|
Yamagata K et al. |
Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. |
2003 |
Glia |
pmid:12509810
|
Marfia G et al. |
Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. |
2014 |
Glia |
pmid:25042636
|
López-Juárez A et al. |
Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. |
2011 |
Glia |
pmid:21319224
|
Yu N et al. |
Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. |
2004 |
Glia |
pmid:14648542
|
Shirakawa H et al. |
Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
|
Bassi R et al. |
Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. |
2006 |
Glia |
pmid:16470810
|
Wang S et al. |
A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. |
2010 |
Glycobiology |
pmid:20008963
|
Kohno T and Igarashi Y |
Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. |
2004 |
Glycoconj. J. |
pmid:15750791
|
Ranty ML et al. |
Ceramide production associated with retinal apoptosis after retinal detachment. |
2009 |
Graefes Arch. Clin. Exp. Ophthalmol. |
pmid:18958490
|
Li S et al. |
Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
2017 |
Gynecol. Endocrinol. |
pmid:28277139
|
Hancke K et al. |
Ovarian transplantation for fertility preservation in a sheep model: can follicle loss be prevented by antiapoptotic sphingosine-1-phosphate administration? |
2009 |
Gynecol. Endocrinol. |
pmid:19906004
|
Jee BC et al. |
Dose-dependent effect of sphingosine-1-phosphate in mouse oocyte maturation medium on subsequent embryo development. |
2011 |
Gynecol. Obstet. Invest. |
pmid:21160167
|
Smicun Y et al. |
S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. |
2007 |
Gynecol. Oncol. |
pmid:17716713
|
Devine KM et al. |
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. |
2008 |
Gynecol. Oncol. |
pmid:18513786
|
Schwartz BM et al. |
Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. |
2001 |
Gynecol. Oncol. |
pmid:11330965
|
Smicun Y et al. |
S1P regulation of ovarian carcinoma invasiveness. |
2006 |
Gynecol. Oncol. |
pmid:16956652
|
Montecucco F et al. |
Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions. |
2015 |
Handb Exp Pharmacol |
pmid:25522998
|
Nofer JR |
Signal transduction by HDL: agonists, receptors, and signaling cascades. |
2015 |
Handb Exp Pharmacol |
pmid:25522990
|
Zu Heringdorf DM et al. |
Pharmacology of the sphingosine-1-phosphate signalling system. |
2013 |
Handb Exp Pharmacol |
pmid:23579459
|
Selvam SP and Ogretmen B |
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. |
2013 |
Handb Exp Pharmacol |
pmid:23563649
|
Pyne S and Pyne NJ |
New perspectives on the role of sphingosine 1-phosphate in cancer. |
2013 |
Handb Exp Pharmacol |
pmid:23563651
|
Jiang XC and Liu J |
Sphingolipid metabolism and atherosclerosis. |
2013 |
Handb Exp Pharmacol |
pmid:23563655
|
Levkau B |
Cardiovascular effects of sphingosine-1-phosphate (S1P). |
2013 |
Handb Exp Pharmacol |
pmid:23563656
|
Abbasi T and Garcia JG |
Sphingolipids in lung endothelial biology and regulation of vascular integrity. |
2013 |
Handb Exp Pharmacol |
pmid:23563658
|
Gandy KA and Obeid LM |
Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. |
2013 |
Handb Exp Pharmacol |
pmid:23563662
|
Bruni P and Donati C |
Role of sphingosine 1-phosphate in skeletal muscle cell biology. |
2013 |
Handb Exp Pharmacol |
pmid:23563671
|
Minshall RD and Malik AB |
Transport across the endothelium: regulation of endothelial permeability. |
2006 |
Handb Exp Pharmacol |
pmid:16999218
|
Park TS and Goldberg IJ |
Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. |
2012 |
Heart Fail Clin |
pmid:22999245
|
Keul P et al. |
HDL and its sphingosine-1-phosphate content in cardioprotection. |
2007 |
Heart Fail Rev |
pmid:17554629
|
Lee SY et al. |
Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. |
2015 |
Hepatology |
pmid:25808625
|
Zheng DM et al. |
Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. |
2006 |
Hepatology |
pmid:17058266
|
Wang Y et al. |
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
2017 |
Hepatology |
pmid:28120434
|
Lee JF et al. |
Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. |
2006 |
Histochem. Cell Biol. |
pmid:16416022
|
Wang L et al. |
Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells. |
2008 |
Histochem. Cell Biol. |
pmid:18247041
|
Estrada R et al. |
Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. |
2009 |
Histochem. Cell Biol. |
pmid:18936953
|
Wu YP et al. |
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. |
2008 |
Hum. Mol. Genet. |
pmid:18424450
|
Moruno-Manchon JF et al. |
Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. |
2017 |
Hum. Mol. Genet. |
pmid:28175299
|
Janecke AR et al. |
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. |
2017 |
Hum. Mutat. |
pmid:28181337
|
Li F et al. |
Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. |
2014 |
Hum. Reprod. |
pmid:24221908
|
Zhang J et al. |
Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. |
2013 |
Hum. Reprod. |
pmid:24001716
|
Onions VJ et al. |
Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion. |
2008 |
Hum. Reprod. |
pmid:18216042
|
Yogi A et al. |
Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. |
2011 |
Hypertension |
pmid:21383307
|
Tar L and Vécsei L |
[Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism]. |
2012 |
Ideggyogy Sz |
pmid:23136726
|
Cortez-Retamozo V et al. |
Angiotensin II drives the production of tumor-promoting macrophages. |
2013 |
Immunity |
pmid:23333075
|
Poissonnier A et al. |
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. |
2016 |
Immunity |
pmid:27438772
|
St John AL et al. |
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. |
2014 |
Immunity |
pmid:25238098
|
Davis KM and Isberg RR |
Plague's partners in crime. |
2014 |
Immunity |
pmid:25238090
|
Luo B et al. |
Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. |
2016 |
Immunity |
pmid:26872696
|
Olivera A et al. |
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. |
2007 |
Immunity |
pmid:17346996
|
Kurobe H et al. |
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. |
2006 |
Immunity |
pmid:16473829
|
Dustin ML and Chakraborty AK |
Tug of war at the exit door. |
2008 |
Immunity |
pmid:18199414
|
Weigert A et al. |
Regulation of macrophage function by sphingosine-1-phosphate. |
2009 |
Immunobiology |
pmid:19625101
|
Voelkel NF and Spiegel S |
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma. |
2009 Nov-Dec |
Immunol. Cell Biol. |
pmid:19546879
|
Kim CH |
Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. |
2009 |
Immunol. Cell Biol. |
pmid:19652661
|
Dziak R |
The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. |
2013 |
Immunol. Invest. |
pmid:24004055
|
Eigenbrod S et al. |
Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells. |
2006 |
Immunol. Invest. |
pmid:16698674
|
Schulz C et al. |
Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue. |
2009 |
Immunol. Res. |
pmid:19340403
|
Greco E et al. |
Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. |
2010 |
Immunology |
pmid:19878354
|
Turner VM and Mabbott NA |
Ageing adversely affects the migration and function of marginal zone B cells. |
2017 |
Immunology |
pmid:28369800
|
Thamilselvan V et al. |
Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. |
2002 |
In Vitro Cell. Dev. Biol. Anim. |
pmid:12197778
|