| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang W et al. | Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23770055 |
| Cinq-Frais C et al. | A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. | 2013 | Biochim. Biophys. Acta | pmid:23651497 |
| Christoffersen C and Nielsen LB | Apolipoprotein M: bridging HDL and endothelial function. | 2013 | Curr. Opin. Lipidol. | pmid:23652568 |
| Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
| Barth BM et al. | Gaucher's disease and cancer: a sphingolipid perspective. | 2013 | Crit Rev Oncog | pmid:23510065 |
| Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
| Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
| Fournie P et al. | Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446906 |
| Tse KW et al. | Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | 2012 Jan-Feb | Cell. Immunol. | pmid:22507871 |
| Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
| Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
| Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
| Park TS and Goldberg IJ | Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. | 2012 | Heart Fail Clin | pmid:22999245 |
| Ihlefeld K et al. | Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2012 | Biochem. J. | pmid:22908849 |
| Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
| Chiba K and Yoshii N | [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. | 2012 | Nippon Yakurigaku Zasshi | pmid:22728990 |
| Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
| Yokoyama K et al. | Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | 2012 | Clin. Nephrol. | pmid:22732343 |
| Czarnota GJ et al. | Tumor radiation response enhancement by acoustical stimulation of the vasculature. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22778441 |
| Sun DF et al. | Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. | 2012 | Cancer Lett. | pmid:22261335 |
| Park SW et al. | Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. | 2012 | J. Am. Soc. Nephrol. | pmid:22095950 |
| Liu X et al. | Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. | 2012 | Mol. Cell. Biochem. | pmid:22113622 |
| Liu X et al. | ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. | 2012 | Clin. Chim. Acta | pmid:22115863 |
| Spiegel S et al. | Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. | 2012 | Oncogene | pmid:21725353 |
| Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
| Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
| Ponnusamy S et al. | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | 2012 | EMBO Mol Med | pmid:22707406 |
| Kunisawa J and Kiyono H | Immunological function of sphingosine 1-phosphate in the intestine. | 2012 | Nutrients | pmid:22666543 |
| Tencé M et al. | Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists. | 2012 | Cell. Signal. | pmid:21872657 |
| Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
| Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
| Asghar MY et al. | Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | 2012 | Endocr. Relat. Cancer | pmid:22889737 |
| Kim BJ et al. | Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22879631 |
| Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
| Beckham TH et al. | Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. | 2012 | Int. J. Cancer | pmid:22322590 |
| Brizuela L et al. | First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. | 2012 | Mol. Cancer Ther. | pmid:22784711 |
| Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
| Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
| Härmä V et al. | Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models. | 2012 | Oncogene | pmid:21996742 |
| Zhang L et al. | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. | 2012 | J. Exp. Med. | pmid:23148237 |
| Qiao Y et al. | Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:23150617 |
| Bieberich E | It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. | 2012 | Neurochem. Res. | pmid:22246226 |
| Bhattacharya M et al. | IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22561460 |
| Spohr TC et al. | Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells. | 2012 | J. Neurosci. Res. | pmid:22588662 |
| Parrill AL et al. | Structure of the first sphingosine 1-phosphate receptor. | 2012 | Sci Signal | pmid:22623751 |
| Giacomini MM et al. | Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. | 2012 | Exp. Cell Res. | pmid:22309779 |
| Trifilieff A and Fozard JR | Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22570366 |
| Van Brocklyn JR and Williams JB | The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. | 2012 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:22613819 |
| Yonesu K and Nara F | [Anti-angiogenic effect of bioactive lipid antagonists]. | 2012 | Nippon Rinsho | pmid:23513926 |
| Reina E et al. | Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. | 2012 | Chem. Phys. Lipids | pmid:22265672 |