Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Authors Title Published Journal PubMed Link
Abuhusain HJ et al. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis. 2013 J. Biol. Chem. pmid:24265321
Bolli MH et al. Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes. 2013 J. Med. Chem. pmid:24266709
Das A et al. The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. 2013 Biomaterials pmid:24064148
Garris CS et al. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. 2013 Nat. Immunol. pmid:24076635
Koch A et al. PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. 2013 Biochim. Biophys. Acta pmid:23906789
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Zhao CG et al. Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. 2013 Physiol Res pmid:23869887
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Cortez-Retamozo V et al. Angiotensin II drives the production of tumor-promoting macrophages. 2013 Immunity pmid:23333075
Ono Y et al. Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. 2013 Lipids Health Dis pmid:23418753
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Arce FT et al. Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. 2013 Nanomedicine pmid:23523769
Herr DR et al. Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. 2013 J. Biol. Chem. pmid:24003216
Dave JM et al. Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). 2013 J. Biol. Chem. pmid:24005669
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Karliner JS Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. 2013 Biochim. Biophys. Acta pmid:22735359
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Yu H et al. Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. 2013 PLoS ONE pmid:24349009
Walls SM et al. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. 2013 PLoS Genet. pmid:24339790
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Ley S et al. The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. 2013 Oncogene pmid:22410777
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Kunkel GT et al. Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. 2013 Nat Rev Drug Discov pmid:23954895
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Beckham TH et al. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. 2013 PLoS ONE pmid:24098536
Xiong Y et al. Sphingosine kinases are not required for inflammatory responses in macrophages. 2013 J. Biol. Chem. pmid:24081141
Zhang W et al. ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. 2013 J. Biol. Chem. pmid:24064218
Babahosseini H et al. Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. 2013 Integr Biol (Camb) pmid:24056950
Zhang O et al. Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. 2013 Mol. Microbiol. pmid:23980754
Olivera A et al. Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. 2013 J. Leukoc. Biol. pmid:23904439
Reichardt P et al. A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. 2013 EMBO J. pmid:23443048
Natarajan V et al. Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. 2013 Am. J. Respir. Cell Mol. Biol. pmid:23449739
Kusch A et al. Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. 2013 Acta Physiol (Oxf) pmid:23432924
Loetscher E et al. Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors. 2013 Biochem. Biophys. Res. Commun. pmid:23499842
Moriue T et al. Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro. 2013 Clin. Exp. Dermatol. pmid:23837937
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Gao X et al. Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. 2013 Lipids pmid:23881382
Karimian G et al. Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. 2013 Biochim. Biophys. Acta pmid:23816565
Liu Y et al. Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. 2013 J. Pathol. pmid:23839903
Riccitelli E et al. Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. 2013 PLoS ONE pmid:23826381
Wang Y et al. Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. 2013 Endocrinology pmid:23787120
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Salmanzadeh A et al. Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. 2013 Integr Biol (Camb) pmid:23609351
Orr Gandy KA et al. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. 2013 FASEB J. pmid:23629860
Xu Y et al. Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. 2013 Am. J. Respir. Cell Mol. Biol. pmid:23239501
Evindar G et al. Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. 2013 Bioorg. Med. Chem. Lett. pmid:23245510
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Kleinjan A et al. Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. 2013 Allergy pmid:23253209
Kager LM et al. Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). 2013 J. Thromb. Haemost. pmid:23216621
Liang J et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. 2013 Cancer Cell pmid:23273921
Jiang LI et al. Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. 2013 Mol. Pharmacol. pmid:23229509
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Camprubí-Robles M et al. Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. 2013 J. Neurosci. pmid:23392686
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