Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Knapp M | Cardioprotective role of sphingosine-1-phosphate. | 2011 | J. Physiol. Pharmacol. | pmid:22314562 |
| Berdyshev EV et al. | Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | 2011 | PLoS ONE | pmid:21304987 |
| Schuchardt M et al. | Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. | 2011 | Br. J. Pharmacol. | pmid:21309759 |
| Kikuta J et al. | [Encounter of cancer cells with bone. In vivo imaging of osteoclasts and their precursors in intact bone tissues]. | 2011 | Clin Calcium | pmid:21358058 |
| Mair N et al. | Genetic evidence for involvement of neuronally expressed S1Pâ‚ receptor in nociceptor sensitization and inflammatory pain. | 2011 | PLoS ONE | pmid:21359147 |
| Morris MA et al. | Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. | 2011 | Autoimmunity | pmid:20695767 |
| Ishii T et al. | The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. | 2011 | Mol. Cells | pmid:21360199 |
| Antel J and Hohlfeld R | Modulation of sphingosine 1-phosphate signaling in neurologic disease. | 2011 | Neurology | pmid:21360856 |
| Lépine S et al. | Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. | 2011 | Cell Death Differ. | pmid:20798685 |
| Kim MG et al. | CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | 2011 | Nephrol. Dial. Transplant. | pmid:20702533 |
| Jiang Z et al. | Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | 2011 | Biomed. Chromatogr. | pmid:20812204 |
| Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
| Adyshev DM et al. | Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. | 2011 | Cell. Signal. | pmid:21864676 |
| Selim S et al. | Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. | 2011 | Clin. Sci. | pmid:21749329 |
| Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype. | 2011 | J. Pharm. Pharmacol. | pmid:21749389 |
| Kojima K and Inouye K | Activation of matriptase zymogen. | 2011 | J. Biochem. | pmid:21737400 |
| AL-Shawaf E et al. | GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels. | 2011 | Cell Calcium | pmid:21742378 |
| Bautista-Pérez R et al. | Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats. | 2011 | Diabetes Res. Clin. Pract. | pmid:21775010 |
| Roviezzo F et al. | Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21421740 |
| Murakami M et al. | Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. | 2011 | J. Cell. Biochem. | pmid:21769916 |
| Yu Y and Qin SC | [An active lipid signaling molecule: sphingosine-1-phosphate and its biological characteristics]. | 2011 | Sheng Li Ke Xue Jin Zhan | pmid:21770269 |
| Tanfin Z et al. | ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium. | 2011 | Cell. Signal. | pmid:21803151 |
| Gault CR and Obeid LM | Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21787121 |
| Lee YS et al. | Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest. | 2011 | Cell Prolif. | pmid:21645154 |
| Zhao Z et al. | Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. | 2011 | J. Biomed. Sci. | pmid:21645412 |
| Kim ES et al. | Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling. | 2011 | J. Cell. Sci. | pmid:21652634 |
| Lim KG et al. | (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. | 2011 | Cell. Signal. | pmid:21620961 |
| Egom EE et al. | Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21705677 |
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| Burns TA and Luberto C | Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches. | 2011 | Anticancer Agents Med Chem | pmid:21707485 |
| Cuvillier O and Ader I | Hypoxia-inducible factors and sphingosine 1-phosphate signaling. | 2011 | Anticancer Agents Med Chem | pmid:21707486 |
| Bedia C et al. | Regulation of autophagy by sphingolipids. | 2011 | Anticancer Agents Med Chem | pmid:21707487 |
| Weigert A et al. | S1P regulation of macrophage functions in the context of cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707489 |
| Watters RJ et al. | Targeting sphingosine-1-phosphate receptors in cancer. | 2011 | Anticancer Agents Med Chem | pmid:21707490 |
| Sánchez BA et al. | Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. | 2011 | Anal Bioanal Chem | pmid:21394454 |
| Dickson MA et al. | A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. | 2011 | Clin. Cancer Res. | pmid:21257722 |
| Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
| Kumar A et al. | S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. | 2011 | Cell Death Dis | pmid:21368890 |
| Schröder M et al. | The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. | 2011 | Mol. Immunol. | pmid:21435724 |
| Kujjo LL et al. | Chemotherapy-induced late transgenerational effects in mice. | 2011 | PLoS ONE | pmid:21437292 |
| Bandhuvula P et al. | S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21335477 |
| Kennedy AJ et al. | Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. | 2011 | J. Med. Chem. | pmid:21495716 |
| Jenkins RW et al. | Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. | 2011 | J. Biol. Chem. | pmid:21335555 |
| Pinschewer DD et al. | Impact of sphingosine 1-phosphate modulation on immune outcomes. | 2011 | Neurology | pmid:21339486 |
| Mehling M et al. | Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis. | 2011 | Neurology | pmid:21339487 |
| Hla T and Brinkmann V | Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. | 2011 | Neurology | pmid:21339489 |
| Soliven B et al. | The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. | 2011 | Neurology | pmid:21339490 |
| Brecht K et al. | Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. | 2011 | FASEB J. | pmid:21450910 |
| Benamer N et al. | Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21420933 |
| Ocaña-Morgner C et al. | Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. | 2011 | J. Immunol. | pmid:21421853 |
| Delogu G et al. | Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection. | 2011 | Cell. Immunol. | pmid:21703599 |
| Strub GM et al. | Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. | 2011 | FASEB J. | pmid:20959514 |
| Sekine Y et al. | HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. | 2011 | Prostate | pmid:20979115 |
| Noguchi K and Chun J | Roles for lysophospholipid S1P receptors in multiple sclerosis. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:20979571 |
| Becker S et al. | Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. | 2011 | Biol. Reprod. | pmid:20980685 |
| Barra V et al. | Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. | 2011 | Cell. Mol. Life Sci. | pmid:20949368 |
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| Kim YM et al. | G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21212405 |
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| Gaveglio VL et al. | Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells. | 2011 | Arch. Biochem. Biophys. | pmid:21216221 |
| Ter Braak M et al. | Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator. | 2011 | Biochem. Pharmacol. | pmid:21163254 |
| Markiewicz M et al. | Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. | 2011 | Microcirculation | pmid:21166920 |
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| Jongsma M et al. | LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. | 2011 | PLoS ONE | pmid:22195035 |
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| Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
| Kang H et al. | Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices. | 2011 | J. Biol. Chem. | pmid:22002053 |
| Kartal M et al. | Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells. | 2011 | Nutr Cancer | pmid:21500096 |
| Costello RW et al. | Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells. | 2011 | Int J Mol Sci | pmid:21686182 |
| Serebrov VIu et al. | [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. | 2010 Mar-Apr | Biomed Khim | pmid:21341516 |
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| Dunlap KA et al. | The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep. | 2010 | Biol. Reprod. | pmid:20107206 |
| Takabe K et al. | Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. | 2010 | J. Biol. Chem. | pmid:20110355 |
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| Yonesu K et al. | A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate. | 2010 | Biol. Pharm. Bull. | pmid:20823564 |
| Canals D et al. | Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. | 2010 | J. Biol. Chem. | pmid:20679347 |
| Dhami R et al. | Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice. | 2010 | Cell. Physiol. Biochem. | pmid:21063112 |
| Ratajczak MZ et al. | Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. | 2010 | Leukemia | pmid:20357827 |
| Alford SK et al. | Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements. | 2010 | Ann Biomed Eng | pmid:20358290 |
| Sun HY et al. | Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20382120 |
| Liu G et al. | The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. | 2010 | Nat. Immunol. | pmid:20852647 |
| Scherer EQ et al. | Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. | 2010 | Stroke | pmid:20930159 |
| Hirahara K et al. | Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. | 2010 | Cytokine Growth Factor Rev. | pmid:21084214 |
| Kułakowska A et al. | Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis. | 2010 | Neurosci. Lett. | pmid:20434523 |
| Szczepaniak WS et al. | S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20435688 |
| Muscoli C et al. | Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. | 2010 | J. Neurosci. | pmid:21084596 |
| Tawa H et al. | Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. | 2010 | Circ. Res. | pmid:20413783 |
| Bolli MH et al. | 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists. | 2010 | J. Med. Chem. | pmid:20446681 |
| Pattanaik D and Postlethwaite AE | A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis. | 2010 | Discov Med | pmid:20807477 |
| Ito S et al. | Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19648475 |
| Alvarez SE et al. | Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. | 2010 | Nature | pmid:20577214 |
| Kamradt T and Frey O | Arthritis: where are the T cells? | 2010 | Arthritis Res. Ther. | pmid:20537200 |
| Esche M et al. | Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. | 2010 | Neurosci. Lett. | pmid:20540988 |