Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lépine S et al. | Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. | 2011 | J. Biol. Chem. | pmid:22052905 |
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| Wang L et al. | FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. | 2011 | Eur. Respir. J. | pmid:21071472 |
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| Cho MC et al. | Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats. | 2011 | J Sex Med | pmid:21143420 |
| Li C et al. | Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. | 2011 | J. Hepatol. | pmid:21145832 |
| Zhao Y et al. | Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21148740 |
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| Samadi N et al. | Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. | 2011 | Biochimie | pmid:20709140 |
| Yogi A et al. | Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension. | 2011 | Hypertension | pmid:21383307 |
| Zhu Q et al. | A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21478479 |
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| Jackson EK | Role of sphingosine-1-phosphate in the renal medulla. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21511695 |
| Salas A et al. | Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. | 2011 | Blood | pmid:21527515 |
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| Lim KG et al. | FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. | 2011 | J. Biol. Chem. | pmid:21464128 |
| Jung M et al. | Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin. | 2011 | Exp. Dermatol. | pmid:21366697 |
| Pyne S and Pyne NJ | Translational aspects of sphingosine 1-phosphate biology. | 2011 | Trends Mol Med | pmid:21514226 |
| Strub GM et al. | Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. | 2011 | FASEB J. | pmid:20959514 |
| Bolli MH et al. | Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls. | 2011 | Curr Top Med Chem | pmid:21261590 |
| Hopson KP et al. | S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21270296 |
| Ulrych T et al. | Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. | 2011 | J. Thromb. Haemost. | pmid:21251196 |
| Catarzi S et al. | Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor. | 2011 | Biochim. Biophys. Acta | pmid:21256191 |
| Beljanski V et al. | Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. | 2011 | Cancer Biol. Ther. | pmid:21258214 |
| Doyle T et al. | Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. | 2011 | Pain | pmid:21239112 |
| Bouma HR et al. | Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21245336 |
| Aarthi JJ et al. | Dissecting the role of the S1P/S1PR axis in health and disease. | 2011 | J. Dent. Res. | pmid:21248363 |
| Sumida GM and Stamer WD | S1Pâ‚‚ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21289286 |
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| Lee SY et al. | Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice. | 2011 | Nephrology (Carlton) | pmid:21272128 |
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| Arnon TI et al. | GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. | 2011 | Science | pmid:21960637 |
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| Kelly RF et al. | Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | 2010 | Basic Res. Cardiol. | pmid:20938668 |
| Meacci E et al. | Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. | 2010 | Cell. Mol. Life Sci. | pmid:20614160 |
| Sumida GM and Stamer WD | Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592229 |
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