Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pandey S and Assmann SM | The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. | 2004 | Plant Cell | pmid:15155892 |
| Taha TA et al. | Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. | 2004 | Biochim. Biophys. Acta | pmid:15158755 |
| Duong CQ et al. | Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. | 2004 | Biochim. Biophys. Acta | pmid:15158762 |
| Zhou H and Murthy KS | Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075212 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Hung RJ et al. | Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075215 |
| Wang W et al. | Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. | 2004 | FASEB J. | pmid:15084513 |
| Renkl A et al. | Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. | 2004 | Int. J. Mol. Med. | pmid:14719124 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Shimamura K et al. | Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:14975703 |
| Yatomi Y et al. | Sphingosine 1-phosphate breakdown in platelets. | 2004 | J. Biochem. | pmid:15625319 |
| Galaria II et al. | Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. | 2004 | J. Surg. Res. | pmid:15555614 |
| Shida D et al. | Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. | 2004 | FEBS Lett. | pmid:15556605 |
| Langlois S et al. | Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. | 2004 | Blood | pmid:15070679 |
| Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
| vom Dorp F et al. | Inhibition of phospholipase C-epsilon by Gi-coupled receptors. | 2004 | Cell. Signal. | pmid:15157671 |
| Allende ML et al. | Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. | 2004 | J. Biol. Chem. | pmid:15459201 |
| Yamanaka M et al. | Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. | 2004 | J. Biol. Chem. | pmid:15485866 |
| Alewijnse AE et al. | Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. | 2004 | Br. J. Pharmacol. | pmid:15504747 |
| Mo FM et al. | Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. | 2004 | Eur. J. Pharmacol. | pmid:15063151 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
| McVerry BJ et al. | Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15282202 |
| Ogretmen B and Hannun YA | Biologically active sphingolipids in cancer pathogenesis and treatment. | 2004 | Nat. Rev. Cancer | pmid:15286740 |
| Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
| De Luca T et al. | NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. | 2005 | Biofactors | pmid:16873929 |
| Lindner K et al. | Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. | 2005 | Br. J. Pharmacol. | pmid:15735657 |
| Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
| Yabu T et al. | Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | 2005 | Blood | pmid:15741222 |
| Kee TH et al. | Sphingosine kinase signalling in immune cells. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743396 |
| Suomalainen L et al. | Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. | 2005 | Am. J. Pathol. | pmid:15743789 |
| Pilorget A et al. | Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. | 2005 | J. Cereb. Blood Flow Metab. | pmid:15829917 |
| Bolick DT et al. | Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15761190 |
| Blom T et al. | Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. | 2005 | Cell. Signal. | pmid:15763425 |
| Itagaki K et al. | Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. | 2005 | J. Leukoc. Biol. | pmid:15522918 |
| McVerry BJ and Garcia JG | In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. | 2005 | Cell. Signal. | pmid:15494205 |
| Waters CM et al. | c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | 2005 | Cell. Signal. | pmid:15494217 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Hsiao SH et al. | Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | 2005 | Toxicol. Sci. | pmid:15829618 |
| Geoffroy K et al. | Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. | 2005 | FEBS Lett. | pmid:15710421 |
| Takashiro Y et al. | Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. | 2005 | Biochem. Pharmacol. | pmid:15907808 |
| Halin C et al. | The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. | 2005 | Blood | pmid:15870184 |
| Takeshita A et al. | Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. | 2005 | J Oral Sci | pmid:15881228 |
| Sauer B et al. | Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. | 2005 | Pharmazie | pmid:15881612 |
| Ma Y et al. | Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. | 2005 | J. Biol. Chem. | pmid:15883165 |
| Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
| Yin F and Watsky MA | LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15914605 |
| Wu WT et al. | Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. | 2005 | Endocrinology | pmid:15878967 |
| Long J et al. | Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. | 2005 | Biochem. J. | pmid:15960610 |
| Malchinkhuu E et al. | Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. | 2005 | Oncogene | pmid:16007180 |