Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Noguchi K and Chun J | Roles for lysophospholipid S1P receptors in multiple sclerosis. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:20979571 |
Sekine Y et al. | HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion. | 2011 | Prostate | pmid:20979115 |
Wang F et al. | Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. | 2010 | J. Clin. Invest. | pmid:20978351 |
Strub GM et al. | Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. | 2011 | FASEB J. | pmid:20959514 |
Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
Kanno T et al. | Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. | 2010 | Neuroscience | pmid:20950672 |
Barra V et al. | Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB. | 2011 | Cell. Mol. Life Sci. | pmid:20949368 |
Chiba Y et al. | SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | 2010 | J. Pharmacol. Sci. | pmid:20948165 |
Su SC et al. | Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. | 2010 | J. Biol. Chem. | pmid:20947498 |
Kelly RF et al. | Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | 2010 | Basic Res. Cardiol. | pmid:20938668 |
Greenspon J et al. | Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. | 2011 | Dig. Dis. Sci. | pmid:20936358 |
Zhang N et al. | FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy. | 2010 | Autophagy | pmid:20935520 |
Scherer EQ et al. | Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling. | 2010 | Stroke | pmid:20930159 |
Oskouian B and Saba JD | Cancer treatment strategies targeting sphingolipid metabolism. | 2010 | Adv. Exp. Med. Biol. | pmid:20919655 |
Strub GM et al. | Extracellular and intracellular actions of sphingosine-1-phosphate. | 2010 | Adv. Exp. Med. Biol. | pmid:20919652 |
Watson C et al. | High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. | 2010 | Am. J. Pathol. | pmid:20889557 |
Komatsu I et al. | Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. | 2010 | J Hand Surg Am | pmid:20888494 |
Dudek SM et al. | Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. | 2010 | Mol. Biol. Cell | pmid:20861316 |
Gil PR et al. | Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₠and S1P₃ and Smad-signalling. | 2010 | Cytoskeleton (Hoboken) | pmid:20857421 |
Liu G et al. | The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. | 2010 | Nat. Immunol. | pmid:20852647 |
Chi XX and Nicol GD | The sphingosine 1-phosphate receptor, S1PRâ‚, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. | 2010 | J. Neurophysiol. | pmid:20844107 |
Deshpande GP et al. | Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF). | 2010 | Cardiovasc Drugs Ther | pmid:20838867 |
Long JS et al. | Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. | 2010 | J. Biol. Chem. | pmid:20837468 |
Durafourt BA et al. | Differential responses of human microglia and blood-derived myeloid cells to FTY720. | 2011 | J. Neuroimmunol. | pmid:20826007 |
Yonesu K et al. | A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate. | 2010 | Biol. Pharm. Bull. | pmid:20823564 |
Jiang Z et al. | Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | 2011 | Biomed. Chromatogr. | pmid:20812204 |
Bäumer W et al. | Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. | 2011 | J. Invest. Dermatol. | pmid:20811395 |
Bucki R et al. | Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20810916 |
Pattanaik D and Postlethwaite AE | A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis. | 2010 | Discov Med | pmid:20807477 |
Berdyshev EV et al. | Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. | 2011 | Anal. Biochem. | pmid:20804717 |
Lépine S et al. | Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. | 2011 | Cell Death Differ. | pmid:20798685 |
Wuertz CM et al. | p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. | 2010 | FASEB J. | pmid:20739613 |
Im DS | Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. | 2010 | Acta Pharmacol. Sin. | pmid:20729877 |
Zhang G et al. | Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20729401 |
Nelson CJ et al. | Global analysis of circulating metabolites in hibernating ground squirrels. | 2010 | Comp. Biochem. Physiol. Part D Genomics Proteomics | pmid:20728417 |
Mair KM et al. | Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | 2010 | Br. J. Pharmacol. | pmid:20718749 |
Swan DJ et al. | Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. | 2010 | J. Cell. Mol. Med. | pmid:20716131 |
Nishimura B et al. | The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea. | 2010 | Neurosci. Lett. | pmid:20709153 |
Samadi N et al. | Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance. | 2011 | Biochimie | pmid:20709140 |
Medlin MD et al. | Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20702813 |
Kim MG et al. | CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. | 2011 | Nephrol. Dial. Transplant. | pmid:20702533 |
Bourquin F et al. | Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. | 2010 | Structure | pmid:20696404 |
Morris MA et al. | Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. | 2011 | Autoimmunity | pmid:20695767 |
Chumanevich AA et al. | Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. | 2010 | Carcinogenesis | pmid:20688834 |
Canals D et al. | Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. | 2010 | J. Biol. Chem. | pmid:20679347 |
Jee BC et al. | Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts. | 2010 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:20674140 |
Tengood JE et al. | Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. | 2010 | Biomaterials | pmid:20674008 |
Hoefer J et al. | Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. | 2010 | Circ. Res. | pmid:20671234 |
Weis T et al. | Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells. | 2010 | Eur. J. Cell Biol. | pmid:20656374 |
Sattler KJ et al. | Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. | 2010 | Basic Res. Cardiol. | pmid:20652276 |
Seo J et al. | Sphingosine-1-phosphate signaling in human submandibular cells. | 2010 | J. Dent. Res. | pmid:20651091 |
Lan T et al. | Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | 2010 | Arch. Biochem. Biophys. | pmid:20646989 |
Baker DA et al. | Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. | 2010 | J. Immunol. | pmid:20644167 |
Rosa JM et al. | Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. | 2010 | Pflugers Arch. | pmid:20640579 |
Gurgui M et al. | Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. | 2010 | Cell. Signal. | pmid:20624458 |
Ohno T et al. | The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling. | 2010 | Biopharm Drug Dispos | pmid:20623701 |
Meacci E et al. | Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. | 2010 | Cell. Mol. Life Sci. | pmid:20614160 |
Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |
Cusack KP and Stoffel RH | S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. | 2010 | Curr Opin Drug Discov Devel | pmid:20597031 |
Vessey DA et al. | Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning. | 2009 Jul-Aug | Oxid Med Cell Longev | pmid:20592769 |
Maiese K | Choices and outcomes: Extending basic biology to clinical care. | 2009 Jul-Aug | Oxid Med Cell Longev | pmid:20592765 |
Sumida GM and Stamer WD | Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592229 |
Kilbey A et al. | Runx regulation of sphingolipid metabolism and survival signaling. | 2010 | Cancer Res. | pmid:20587518 |
Thangada S et al. | Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. | 2010 | J. Exp. Med. | pmid:20584883 |
He X et al. | Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells. | 2010 | J Mol Cell Biol | pmid:20584786 |
Alvarez SE et al. | Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. | 2010 | Nature | pmid:20577214 |
Blom T et al. | An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival. | 2010 | BMC Cell Biol. | pmid:20573281 |
Blachnio-Zabielska A et al. | Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | 2010 | J. Cell. Physiol. | pmid:20568228 |
Valentine WJ et al. | (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. | 2010 | Cell. Signal. | pmid:20566326 |
Fyrst H and Saba JD | An update on sphingosine-1-phosphate and other sphingolipid mediators. | 2010 | Nat. Chem. Biol. | pmid:20559316 |
Pyne NJ and Pyne S | Sphingosine 1-phosphate and cancer. | 2010 | Nat. Rev. Cancer | pmid:20555359 |
Murohara T | Printing a tissue: a new engineering strategy for cardiovascular regeneration. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20554948 |
Chiba Y et al. | Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma. | 2010 | Pharmacol. Res. | pmid:20554039 |
Wirrig C et al. | Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20551970 |
Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
Esche M et al. | Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors. | 2010 | Neurosci. Lett. | pmid:20540988 |
Kamradt T and Frey O | Arthritis: where are the T cells? | 2010 | Arthritis Res. Ther. | pmid:20537200 |
Pchejetski D et al. | Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer. | 2010 | Breast Cancer Res. Treat. | pmid:20535545 |
Lee MH et al. | HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate. | 2010 | J. Lipid Res. | pmid:20522601 |
Seo YJ et al. | Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity. | 2010 | J. Virol. | pmid:20519401 |
De Luca T et al. | Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells. | 2010 | J. Cell. Biochem. | pmid:20518072 |
Long JS et al. | Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. | 2010 | Mol. Cell. Biol. | pmid:20516217 |
Zhou Y et al. | Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. | 2010 | Stroke | pmid:20508187 |
Zhang H et al. | Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. | 1991 | J. Cell Biol. | pmid:2050740 |
Dubin AE et al. | Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. | 2010 | J. Neurosci. | pmid:20505096 |
Lucke S and Levkau B | Endothelial functions of sphingosine-1-phosphate. | 2010 | Cell. Physiol. Biochem. | pmid:20502008 |
Gräler MH | Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. | 2010 | Cell. Physiol. Biochem. | pmid:20502007 |
Bergelin N et al. | S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. | 2010 | Endocrinology | pmid:20501673 |
Prakash H et al. | Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages. | 2010 | PLoS ONE | pmid:20498849 |
Maeda Y et al. | Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. | 2010 | Int. Immunol. | pmid:20497959 |
Müller R et al. | Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells. | 2010 | Tumour Biol. | pmid:20480410 |
Liu Z et al. | Mechanical tugging force regulates the size of cell-cell junctions. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20463286 |
Gorbunova E et al. | Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. | 2010 | J. Virol. | pmid:20463083 |
Bankovich AJ et al. | CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. | 2010 | J. Biol. Chem. | pmid:20463015 |
Itoh R et al. | Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. | 2010 | J. Bone Miner. Metab. | pmid:20458606 |
Park SW et al. | Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. | 2010 | Lab. Invest. | pmid:20458275 |
Cao C et al. | The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. | 2010 | J. Clin. Invest. | pmid:20458145 |
Norman E et al. | Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. | 2010 | J. Neurochem. | pmid:20456020 |
Bolli MH et al. | 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists. | 2010 | J. Med. Chem. | pmid:20446681 |