Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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De Luca T et al. | NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. | 2005 | Biofactors | pmid:16873929 |
Perez GI et al. | A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | 2005 | FASEB J. | pmid:15728664 |
Kee TH et al. | Sphingosine kinase signalling in immune cells. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743396 |
Suomalainen L et al. | Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. | 2005 | Am. J. Pathol. | pmid:15743789 |
Pilorget A et al. | Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. | 2005 | J. Cereb. Blood Flow Metab. | pmid:15829917 |
Bolick DT et al. | Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15761190 |
Blom T et al. | Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. | 2005 | Cell. Signal. | pmid:15763425 |
Im YJ et al. | Study on action mode of sphingosine 1-phosphate in rat hepatocytes. | 2005 | J. Pharmacol. Sci. | pmid:15764837 |
Oberst MD et al. | HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15800053 |
Cyster JG | Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. | 2005 | Annu. Rev. Immunol. | pmid:15771568 |
Church LD et al. | TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. | 2005 | J. Leukoc. Biol. | pmid:15817701 |
Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |
Hojjati MR et al. | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | 2005 | J. Biol. Chem. | pmid:15590644 |
Kihara A et al. | [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16146193 |
Fieger CB et al. | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | 2005 | FASEB J. | pmid:16148028 |
Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
van Meeteren LA et al. | Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. | 2005 | J. Biol. Chem. | pmid:15769751 |
Shida D et al. | Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15649431 |
McVerry BJ and Garcia JG | In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. | 2005 | Cell. Signal. | pmid:15494205 |
Waters CM et al. | c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | 2005 | Cell. Signal. | pmid:15494217 |
Butter JJ et al. | A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16023899 |
Maguire JJ and Davenport AP | Regulation of vascular reactivity by established and emerging GPCRs. | 2005 | Trends Pharmacol. Sci. | pmid:16054240 |
Yopp AC et al. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | 2005 | J. Immunol. | pmid:16116177 |
Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
Hsiao SH et al. | Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | 2005 | Toxicol. Sci. | pmid:15829618 |
Budnik LT and Brunswig-Spickenheier B | Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | 2005 | J. Lipid Res. | pmid:15716590 |
Takashiro Y et al. | Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. | 2005 | Biochem. Pharmacol. | pmid:15907808 |
Halin C et al. | The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. | 2005 | Blood | pmid:15870184 |
Takeshita A et al. | Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. | 2005 | J Oral Sci | pmid:15881228 |
Yin Z and Watsky MA | Chloride channel activity in human lung fibroblasts and myofibroblasts. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15681397 |
Sauer B et al. | Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. | 2005 | Pharmazie | pmid:15881612 |
Ma Y et al. | Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. | 2005 | J. Biol. Chem. | pmid:15883165 |
Radeke HH et al. | Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. | 2005 | J. Immunol. | pmid:15728487 |
Kim JW et al. | Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. | 2005 | Bioorg. Med. Chem. | pmid:15848761 |
Kawata T et al. | Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15850807 |
Pfaff M et al. | Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | 2005 | Respir. Res. | pmid:15927078 |
Petrache I et al. | Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. | 2005 | Nat. Med. | pmid:15852018 |
Mastrandrea LD et al. | Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | 2005 | Diabetes | pmid:15855330 |
Segura BJ et al. | Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710251 |
Kim KS et al. | GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. | 2005 | FASEB J. | pmid:15857892 |
Pettus BJ et al. | The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. | 2005 | Mol. Pharmacol. | pmid:15900018 |
Katsuma S et al. | Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. | 2005 | FEBS Lett. | pmid:15862293 |
Johnstone ED et al. | Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. | 2005 | J. Lipid Res. | pmid:15995175 |
Rosen H and Goetzl EJ | Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. | 2005 | Nat. Rev. Immunol. | pmid:15999095 |
Yin F and Watsky MA | LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15914605 |
Wu WT et al. | Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. | 2005 | Endocrinology | pmid:15878967 |