Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Igarashi J et al. | Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19710365 |
Francis-Goforth KN et al. | Normalization of diabetic wound healing. | 2010 | Surgery | pmid:19703697 |
Frias MA et al. | Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. | 2010 | Cardiovasc. Res. | pmid:19700468 |
Yamamura T | [Molecular target drug development for curing multiple sclerosis]. | 2009 | Brain Nerve | pmid:19697881 |
Zhao YD et al. | Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. | 2009 | Circ. Res. | pmid:19696411 |
Antoon JW et al. | Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. | 2009 | J. Med. Chem. | pmid:19694470 |
Huang YL et al. | Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells. | 2009 | J. Biochem. | pmid:19692429 |
Pasquaré SJ et al. | Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. | 2009 | Arch. Biochem. Biophys. | pmid:19691145 |
Haberberger RV et al. | Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness. | 2009 | J. Allergy Clin. Immunol. | pmid:19665772 |
Rapizzi E et al. | Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. | 2009 | Cell. Mol. Life Sci. | pmid:19662499 |
Ren S et al. | Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. | 2009 | Kidney Int. | pmid:19657322 |
Sarai K et al. | Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19657053 |
Kim CH | Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. | 2009 | Immunol. Cell Biol. | pmid:19652661 |
Ito S et al. | Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19648475 |
Vessey DA et al. | Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19648253 |
Hernandez F et al. | Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat. | 2009 | Mol. Reprod. Dev. | pmid:19645054 |
Wacker BK et al. | Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. | 2009 | Stroke | pmid:19644058 |
Trifilieff A et al. | Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19636535 |
Martin JL et al. | Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. | 2009 | J. Biol. Chem. | pmid:19633297 |
Jung ID et al. | FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. | 2009 | Cell. Signal. | pmid:19632319 |
Morris AJ et al. | Regulation of blood and vascular cell function by bioactive lysophospholipids. | 2009 | J. Thromb. Haemost. | pmid:19630765 |
Rütti S et al. | Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. | 2009 | Endocrinology | pmid:19628574 |
Weigert A et al. | Regulation of macrophage function by sphingosine-1-phosphate. | 2009 | Immunobiology | pmid:19625101 |
Florey O and Haskard DO | Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions. | 2009 | J. Immunol. | pmid:19620297 |
Ohno Y et al. | Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization. | 2009 | Genes Cells | pmid:19619245 |
Weigert A et al. | Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype. | 2009 | Int. J. Cancer | pmid:19618460 |
Syuto T et al. | Mammalian Diaphanous (mDia) may be involved in the signal transduction of sphingosine-1-phosphate on developing actin stress fiber of human fibroblasts. | 2009 Jul-Aug | Wound Repair Regen | pmid:19614924 |
Grabski AD et al. | Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19608972 |
Scott EA et al. | Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. | 2010 | Acta Biomater | pmid:19607945 |
Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
Kimber I et al. | Langerhans cell migration: not necessarily always at the center of the skin sensitization universe. | 2009 | J. Invest. Dermatol. | pmid:19603050 |
Daum G et al. | Sphingosine 1-phosphate: a regulator of arterial lesions. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19592471 |
Natsume H et al. | (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts. | 2009 | Int. J. Mol. Med. | pmid:19578793 |
Nixon GF | Sphingolipids in inflammation: pathological implications and potential therapeutic targets. | 2009 | Br. J. Pharmacol. | pmid:19563535 |
Roviezzo F et al. | Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:19556602 |
Herr B et al. | The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta. | 2009 | Blood | pmid:19549990 |
Voelkel NF and Spiegel S | Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma. | 2009 Nov-Dec | Immunol. Cell Biol. | pmid:19546879 |
Gibbs TC et al. | Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells. | 2009 | Prostate | pmid:19536794 |
Price MM et al. | Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. | 2009 | FASEB J. | pmid:19535686 |
Pyne NJ et al. | New aspects of sphingosine 1-phosphate signaling in mammalian cells. | 2009 | Adv. Enzyme Regul. | pmid:19534035 |
Kobayashi N et al. | Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. | 2009 | J. Biol. Chem. | pmid:19531471 |
Okajima F et al. | [Role of S1P in the lipoprotein-induced actions and their signaling mechanism]. | 2009 | Seikagaku | pmid:19522297 |
Tokumura A et al. | Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis. | 2009 | Int J Med Sci | pmid:19521548 |
Liu X et al. | Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. | 2009 | Burns | pmid:19520517 |
Minamitani C et al. | Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | 2009 | Int. J. Mol. Med. | pmid:19513538 |
Serebrov VY et al. | Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis. | 2008 | Bull. Exp. Biol. Med. | pmid:19513367 |
O'Brien N et al. | Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. | 2009 | J. Lipid Res. | pmid:19509417 |
Taniguchi K et al. | Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. | 2009 | Cancer Sci. | pmid:19493272 |
Sim-Selley LJ et al. | Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. | 2009 | J. Neurochem. | pmid:19493165 |
Schulz C et al. | Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. | 2009 | Microcirculation | pmid:19479622 |
Chang CL et al. | S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19474291 |
Monier A et al. | Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus. | 2009 | Genome Res. | pmid:19451591 |
Chao HH et al. | L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation. | 2010 | J. Nutr. Biochem. | pmid:19447019 |
Li X et al. | Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability. | 2009 | Cancer Lett. | pmid:19446953 |
Peyruchaud O | Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer. | 2009 | Anticancer Agents Med Chem | pmid:19442039 |
Yang G et al. | Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19435851 |
Tao R et al. | Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19433984 |
Mullershausen F et al. | Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. | 2009 | Nat. Chem. Biol. | pmid:19430484 |
Michaud MD et al. | Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19423865 |
Hofmann U et al. | Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. | 2009 | Cardiovasc. Res. | pmid:19416991 |
Guzmán-Hernández ML et al. | Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. | 2009 | J. Biol. Chem. | pmid:19403526 |
Li C et al. | Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. | 2009 | J. Hepatol. | pmid:19398237 |
Ader I et al. | When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | 2009 | Cancer Res. | pmid:19383898 |
Hendriks-Balk MC et al. | Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells. | 2009 | Eur. J. Pharmacol. | pmid:19374869 |
Guillermet-Guibert J et al. | Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug. | 2009 | Mol. Cancer Ther. | pmid:19372554 |
Yu H et al. | Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration. | 2009 | Genes Cells | pmid:19371379 |
Hu W et al. | Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. | 2009 | J. Lipid Res. | pmid:19369694 |
Miranda GE et al. | Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19357361 |
Formigli L et al. | Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation. | 2009 | J. Cell. Sci. | pmid:19351713 |
RodrÃguez C et al. | Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin. | 2009 | Thromb. Haemost. | pmid:19350109 |
Straub AC et al. | Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. | 2009 | Am. J. Pathol. | pmid:19349368 |
Sasaki H et al. | pH dependence of sphingosine aggregation. | 2009 | Biophys. J. | pmid:19348755 |
Schulz C et al. | Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue. | 2009 | Immunol. Res. | pmid:19340403 |
Nincheri P et al. | Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells. | 2009 | Cell. Mol. Life Sci. | pmid:19337690 |
Annabi B et al. | Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. | 2009 | Mol. Carcinog. | pmid:19326372 |
Hayashi H et al. | FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1. | 2009 | Arterioscler. Thromb. Vasc. Biol. | pmid:19325137 |
Scherer M et al. | High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. | 2009 | Clin. Chem. | pmid:19325012 |
Beech DJ et al. | TRPC channel lipid specificity and mechanisms of lipid regulation. | 2009 | Cell Calcium | pmid:19324410 |
Sun X et al. | Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. | 2009 | Microvasc. Res. | pmid:19323978 |
Sali M et al. | Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection. | 2009 Jan-Mar | Int J Immunopathol Pharmacol | pmid:19309565 |
Jongsma M et al. | Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). | 2009 | Br. J. Pharmacol. | pmid:19309361 |
Kenagy RD et al. | Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis. | 2009 | J. Vasc. Surg. | pmid:19307078 |
Green DS et al. | Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. | 2009 | J. Virol. | pmid:19297493 |
Yamane D et al. | Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis. | 2009 | J. Biol. Chem. | pmid:19293152 |
Boyce BF | Sphingosine-1 phosphate: a new player in osteoimmunology. | 2009 | Dev. Cell | pmid:19289077 |
Yin H et al. | Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. | 2009 | J. Biol. Chem. | pmid:19286662 |
He X et al. | Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19285924 |
Milara J et al. | Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis. | 2009 | Eur. J. Pharmacol. | pmid:19285497 |
Li Y and Yu KL | [Advances in thrombin-protease-activated receptor 1-sphingosine 1-phosphate pathway during sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19278594 |
Shimizu M et al. | Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship. | 2009 | J. Pharmacol. Sci. | pmid:19276615 |
Kim RH et al. | Export and functions of sphingosine-1-phosphate. | 2009 | Biochim. Biophys. Acta | pmid:19268560 |
Valverde O et al. | GPR3 receptor, a novel actor in the emotional-like responses. | 2009 | PLoS ONE | pmid:19259266 |
Sandhu KS et al. | Regional heterogeneity in expression of the sphingosine-1-phosphate pathway in the female rat lower urinary tract. | 2009 | Am. J. Obstet. Gynecol. | pmid:19254791 |
Hagen N et al. | Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons. | 2009 | J. Biol. Chem. | pmid:19251691 |
Bandhuvula P et al. | Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19250638 |
Karliner JS | Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19247197 |
de Souza JA et al. | Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I. | 2010 | J. Cell. Mol. Med. | pmid:19243471 |
Schnitzer SE et al. | Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. | 2009 | Mol. Cancer Res. | pmid:19240180 |
Limaye V et al. | The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. | 2009 | Cell. Mol. Biol. Lett. | pmid:19238331 |
Limaye V et al. | Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. | 2009 | Cell. Mol. Biol. Lett. | pmid:19238330 |