Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brinkmann V et al. | FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. | 2004 | Am. J. Transplant. | pmid:15196057 |
| Im DS et al. | Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes. | 2004 | J. Pharmacol. Sci. | pmid:15215654 |
| Pandey S and Assmann SM | The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. | 2004 | Plant Cell | pmid:15155892 |
| Taha TA et al. | Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. | 2004 | Biochim. Biophys. Acta | pmid:15158755 |
| Duong CQ et al. | Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages. | 2004 | Biochim. Biophys. Acta | pmid:15158762 |
| Zhou H and Murthy KS | Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075212 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Hung RJ et al. | Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15075215 |
| Wang W et al. | Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. | 2004 | FASEB J. | pmid:15084513 |
| Dudek SM et al. | Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. | 2004 | J. Biol. Chem. | pmid:15056655 |
| Saba JD and Hla T | Point-counterpoint of sphingosine 1-phosphate metabolism. | 2004 | Circ. Res. | pmid:15059942 |
| Peng X et al. | Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15020292 |
| Usui S et al. | Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. | 2004 | J. Biol. Chem. | pmid:14711826 |
| Gräler MH and Goetzl EJ | The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. | 2004 | FASEB J. | pmid:14715694 |
| Ohmori T et al. | Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2004 | J. Thromb. Haemost. | pmid:14717991 |
| Renkl A et al. | Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells. | 2004 | Int. J. Mol. Med. | pmid:14719124 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Shimamura K et al. | Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. | 2004 | Eur. J. Pharmacol. | pmid:14975703 |
| Tokumura A | Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators. | 2004 | J. Cell. Biochem. | pmid:15258912 |
| Barber SC et al. | S1P and LPA trigger Schwann cell actin changes and migration. | 2004 | Eur. J. Neurosci. | pmid:15217370 |
| Yatomi Y et al. | Sphingosine 1-phosphate breakdown in platelets. | 2004 | J. Biochem. | pmid:15625319 |
| Galaria II et al. | Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration. | 2004 | J. Surg. Res. | pmid:15555614 |
| Shida D et al. | Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells. | 2004 | FEBS Lett. | pmid:15556605 |
| Langlois S et al. | Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. | 2004 | Blood | pmid:15070679 |
| Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
| vom Dorp F et al. | Inhibition of phospholipase C-epsilon by Gi-coupled receptors. | 2004 | Cell. Signal. | pmid:15157671 |
| Allende ML et al. | Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. | 2004 | J. Biol. Chem. | pmid:15459201 |
| Yamanaka M et al. | Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. | 2004 | J. Biol. Chem. | pmid:15485866 |
| Alewijnse AE et al. | Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. | 2004 | Br. J. Pharmacol. | pmid:15504747 |
| Bhattacharya J | Lung injury: sphingosine-1-phosphate to the rescue. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15504814 |
| Ozbay T et al. | ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. | 2004 | Endocr. Res. | pmid:15666826 |
| Mo FM et al. | Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. | 2004 | Eur. J. Pharmacol. | pmid:15063151 |
| Butler J et al. | Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165029 |
| Chae SS et al. | Constitutive expression of the S1P1 receptor in adult tissues. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165038 |
| Gonzalez E et al. | Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. | 2004 | J. Biol. Chem. | pmid:15292187 |
| Lee H et al. | Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism. | 2004 | Am. J. Physiol., Cell Physiol. | pmid:15294853 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
| McVerry BJ et al. | Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15282202 |
| Ogretmen B and Hannun YA | Biologically active sphingolipids in cancer pathogenesis and treatment. | 2004 | Nat. Rev. Cancer | pmid:15286740 |
| Sutphen R et al. | Lysophospholipids are potential biomarkers of ovarian cancer. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15247129 |
| Sauer B et al. | Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. | 2004 | J. Biol. Chem. | pmid:15247277 |
| Bolz SS and Pohl U | Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction. | 2003 Jul-Aug | J. Vasc. Res. | pmid:12913332 |
| Dantas AP et al. | Sphingosine 1-phosphate and control of vascular tone. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742827 |
| Itagaki K and Hauser CJ | Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. | 2003 | J. Biol. Chem. | pmid:12746430 |
| Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. | 2003 | J. Cell. Sci. | pmid:12665551 |
| Ohmori T et al. | Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2003 | Cardiovasc. Res. | pmid:12667959 |
| Muraki K | [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. | 2003 | Nippon Yakurigaku Zasshi | pmid:12673948 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: an enigmatic signalling lipid. | 2003 | Nat. Rev. Mol. Cell Biol. | pmid:12728273 |
| Takeya H et al. | Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. | 2003 | Blood | pmid:12730100 |
| Mendel J et al. | Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. | 2003 | J. Biol. Chem. | pmid:12682045 |
| Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
| Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
| Pacheco YM et al. | Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins. | 2003 | Cell. Mol. Life Sci. | pmid:14685698 |
| Kohno T and Igarashi Y | Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. | 2003 | J. Biochem. | pmid:14688232 |
| Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
| Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
| Malchinkhuu E et al. | Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | 2003 | Biochem. J. | pmid:12470300 |
| Yamagata K et al. | Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. | 2003 | Glia | pmid:12509810 |
| Cho H et al. | Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. | 2003 | FASEB J. | pmid:12514120 |
| Rosenfeldt HM et al. | Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. | 2003 | FASEB J. | pmid:14519658 |
| Waters C et al. | Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. | 2003 | J. Biol. Chem. | pmid:12480944 |
| Lim HS et al. | Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12482430 |
| Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
| Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
| Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
| Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
| Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
| Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
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| Djanani A et al. | Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes. | 2003 | Regul. Pept. | pmid:12972327 |
| Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
| Shikata Y et al. | Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. | 2003 | FASEB J. | pmid:14656986 |
| Niedernberg A et al. | Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. | 2003 | J Biomol Screen | pmid:14567777 |
| Rao TS et al. | Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | 2003 | Brain Res. | pmid:14568343 |
| Sorensen SD et al. | Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. | 2003 | Mol. Pharmacol. | pmid:14573770 |
| Spiegel S and Milstien S | Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. | 2003 | Biochem. Soc. Trans. | pmid:14641029 |
| Ignatov A et al. | Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14592418 |
| Kim DS et al. | Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. | 2003 | Arch. Pharm. Res. | pmid:14560924 |
| Coussin F et al. | Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels. | 2003 | Biochem. Pharmacol. | pmid:14563496 |
| Ozaki H et al. | Sphingosine-1-phosphate signaling in endothelial activation. | 2003 | J. Atheroscler. Thromb. | pmid:14564080 |
| Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
| Bayless KJ and Davis GE | Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651957 |
| Morii T and Weissbach L | Sphingosine 1-phosphate and cell migration: resistance to angiogenesis inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14550287 |
| Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
| Frohnert PW et al. | Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. | 2003 | J. Neuropathol. Exp. Neurol. | pmid:12769191 |
| Hakogi T et al. | Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639553 |
| Arikawa K et al. | Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | 2003 | J. Biol. Chem. | pmid:12810709 |
| Meacci E et al. | Sphingosine 1-phosphate signal transduction in muscle cells. | 2003 | Ital. J. Biochem. | pmid:12833634 |
| Villullas IR et al. | Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. | 2003 | J. Neurosci. Res. | pmid:12836164 |
| Schaphorst KL et al. | Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12626332 |
| Malik ZA et al. | Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | 2003 | J. Immunol. | pmid:12626530 |
| Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
| Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
| Van Brocklyn JR et al. | Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells. | 2003 | Cancer Lett. | pmid:12963123 |
| Olivera A et al. | Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. | 2003 | J. Biol. Chem. | pmid:12963721 |
| Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |
| Fegley AJ et al. | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | 2003 | J. Surg. Res. | pmid:12943808 |
| Lu X et al. | Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. | 2003 | J. Org. Chem. | pmid:12946147 |
| zu Heringdorf DM et al. | Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). | 2003 | Cell. Signal. | pmid:12742228 |