Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lu X et al. | Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. | 2003 | J. Org. Chem. | pmid:12946147 |
Fegley AJ et al. | Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation. | 2003 | J. Surg. Res. | pmid:12943808 |
Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |
Bolz SS and Pohl U | Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction. | 2003 Jul-Aug | J. Vasc. Res. | pmid:12913332 |
Muraki K and Imaizumi Y | A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. | 2003 | J. Pharmacol. Sci. | pmid:12890891 |
Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. | 2003 | FASEB J. | pmid:12890700 |
Pettus BJ et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. | 2003 | FASEB J. | pmid:12890694 |
Sauer B et al. | Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. | 2003 | Melanoma Res. | pmid:12883359 |
Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
Worrall D et al. | Sphingolipids, new players in plant signaling. | 2003 | Trends Plant Sci. | pmid:12878015 |
Kohno T et al. | Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells. | 2003 | Genes Cells | pmid:12875654 |
Kim DS et al. | Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation. | 2003 | Cell. Signal. | pmid:12873705 |
Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |
Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
Annabi B et al. | Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells. | 2003 | Exp. Hematol. | pmid:12842709 |
Villullas IR et al. | Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. | 2003 | J. Neurosci. Res. | pmid:12836164 |
Meacci E et al. | Sphingosine 1-phosphate signal transduction in muscle cells. | 2003 | Ital. J. Biochem. | pmid:12833634 |
Miura S et al. | Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12821130 |
Johnson KR et al. | Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. | 2003 | J. Biol. Chem. | pmid:12815058 |
Arikawa K et al. | Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. | 2003 | J. Biol. Chem. | pmid:12810709 |
Tilly JL | Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. | 2001 | ScientificWorldJournal | pmid:12805661 |
Yamaguchi H et al. | Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells. | 2003 | Biochem. J. | pmid:12803545 |
Thors B et al. | Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. | 2003 | Atherosclerosis | pmid:12801607 |
Kim JI et al. | Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. | 2003 | J. Biol. Chem. | pmid:12796504 |
Bolz SS et al. | Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. | 2003 | Circulation | pmid:12796138 |
Watterson K et al. | Pleiotropic actions of sphingosine-1-phosphate. | 2003 | Prog. Lipid Res. | pmid:12790117 |
Coursol S et al. | Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. | 2003 | Nature | pmid:12789341 |
Chihab R et al. | Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. | 2003 | Cell. Mol. Life Sci. | pmid:12785724 |
Mao C et al. | Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. | 2003 | J. Biol. Chem. | pmid:12783875 |
Graeler MH et al. | Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. | 2003 | J. Biol. Chem. | pmid:12782628 |
Salomone S et al. | S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. | 2003 | Eur. J. Pharmacol. | pmid:12782194 |
Duan HF et al. | [Progress in the study of physiological function of sphingosine 1-phosphate]. | 2003 | Sheng Li Ke Xue Jin Zhan | pmid:12778803 |
Kimura T et al. | High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12775579 |
Frohnert PW et al. | Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. | 2003 | J. Neuropathol. Exp. Neurol. | pmid:12769191 |
Brailoiu E et al. | Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). | 2003 | Biochem. J. | pmid:12749764 |
Itagaki K and Hauser CJ | Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. | 2003 | J. Biol. Chem. | pmid:12746430 |
Dantas AP et al. | Sphingosine 1-phosphate and control of vascular tone. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12742827 |
zu Heringdorf DM et al. | Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). | 2003 | Cell. Signal. | pmid:12742228 |
Takeya H et al. | Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. | 2003 | Blood | pmid:12730100 |
Spiegel S and Milstien S | Sphingosine-1-phosphate: an enigmatic signalling lipid. | 2003 | Nat. Rev. Mol. Cell Biol. | pmid:12728273 |
Mendel J et al. | Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. | 2003 | J. Biol. Chem. | pmid:12682045 |
Buccoliero R and Futerman AH | The roles of ceramide and complex sphingolipids in neuronal cell function. | 2003 | Pharmacol. Res. | pmid:12676515 |
Hla T | Signaling and biological actions of sphingosine 1-phosphate. | 2003 | Pharmacol. Res. | pmid:12676514 |
Muraki K | [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. | 2003 | Nippon Yakurigaku Zasshi | pmid:12673948 |
Ohmori T et al. | Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. | 2003 | Cardiovasc. Res. | pmid:12667959 |
Kim DS et al. | Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. | 2003 | J. Cell. Sci. | pmid:12665551 |
Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |
Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |
Hakogi T et al. | Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639553 |
Malik ZA et al. | Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | 2003 | J. Immunol. | pmid:12626530 |
Schaphorst KL et al. | Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12626332 |
Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
Renault AD et al. | Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. | 2002 | Gene Expr. Patterns | pmid:12617823 |
Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
Osada M et al. | Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | 2002 | Thromb. Res. | pmid:12590954 |
Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
Ignatov A et al. | Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. | 2003 | J. Neurosci. | pmid:12574419 |
Cho H et al. | The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | 2003 | Biochem. J. | pmid:12564955 |
Rábano M et al. | Sphingosine-1-phosphate stimulates cortisol secretion. | 2003 | FEBS Lett. | pmid:12560086 |
Ikeda H et al. | Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. | 2003 | Gastroenterology | pmid:12557151 |
Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
Florio T et al. | Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. | 2003 | Mol. Pharmacol. | pmid:12527801 |
Meacci E et al. | Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. | 2003 | Biochemistry | pmid:12525155 |
Cho H et al. | Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. | 2003 | FASEB J. | pmid:12514120 |
Yamagata K et al. | Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. | 2003 | Glia | pmid:12509810 |
Katsuma S et al. | Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12504122 |
Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
Muraki K et al. | [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491795 |
Hirafuji M et al. | [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491784 |
Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
Yun JK and Kester M | Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | 2002 | Arch. Biochem. Biophys. | pmid:12485605 |
Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
Shikata Y et al. | S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. | 2003 | J. Appl. Physiol. | pmid:12482769 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12482430 |
Waters C et al. | Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. | 2003 | J. Biol. Chem. | pmid:12480944 |
Malchinkhuu E et al. | Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | 2003 | Biochem. J. | pmid:12470300 |
Graeler M and Goetzl EJ | Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. | 2002 | FASEB J. | pmid:12468451 |
Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
Osada M et al. | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12445827 |
Tanski W et al. | Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | 2002 | J. Surg. Res. | pmid:12443721 |
Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
Lampasso JD et al. | Role of protein kinase C alpha in primary human osteoblast proliferation. | 2002 | J. Bone Miner. Res. | pmid:12412804 |
Payne SG et al. | Sphingosine-1-phosphate: dual messenger functions. | 2002 | FEBS Lett. | pmid:12401202 |
Banno Y et al. | Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. | 2003 | Biochem. J. | pmid:12385647 |
Graeler M et al. | Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. | 2002 | J. Immunol. | pmid:12370333 |
Koide Y et al. | Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. | 2002 | J. Med. Chem. | pmid:12361389 |
Kozawa O et al. | Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide. | 2002 | Cell. Signal. | pmid:12359305 |