Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Price MM et al. | A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:22939756 |
Kimizuka K et al. | Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels. | 2013 | Microcirculation | pmid:22913344 |
Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
Zhao CG et al. | Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. | 2013 | Physiol Res | pmid:23869887 |
Taub DD et al. | Distinct energy requirements for human memory CD4 T-cell homeostatic functions. | 2013 | FASEB J. | pmid:22972918 |
Knapp M et al. | Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:24120760 |
Yuan S et al. | Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. | 2013 | PLoS Comput. Biol. | pmid:24098103 |
Wirotanseng LN et al. | Gq rather than G11 preferentially mediates nociceptor sensitization. | 2013 | Mol Pain | pmid:24156378 |
Kurek K et al. | [The role of sphingolipids in selected cardiovascular diseases]. | 2013 | Postepy Hig Med Dosw (Online) | pmid:24088546 |
Kowalski GM et al. | Plasma sphingosine-1-phosphate is elevated in obesity. | 2013 | PLoS ONE | pmid:24039766 |
Ota K et al. | TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. | 2013 | Endocrinology | pmid:23861379 |
Ohotski J et al. | Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. | 2013 | Int. J. Cancer | pmid:22733311 |
Chan H and Pitson SM | Post-translational regulation of sphingosine kinases. | 2013 | Biochim. Biophys. Acta | pmid:22801036 |
Orr Gandy KA and Obeid LM | Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. | 2013 | Biochim. Biophys. Acta | pmid:22801037 |
Saba JD and de la Garza-Rodea AS | S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. | 2013 | Biochim. Biophys. Acta | pmid:22750505 |
Deng H et al. | Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis. | 2013 | ACS Med Chem Lett | pmid:24900589 |
Zhang W et al. | Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23770055 |
Selhub J et al. | Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease. | 2013 | J. Nutr. Biochem. | pmid:24183308 |
Watson DG et al. | The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. | 2013 | Cell. Signal. | pmid:23314175 |
Ohkawa R et al. | [Sphingolipids, possible biomarkers for atherosclerotic disorders]. | 2013 | Rinsho Byori | pmid:24369591 |
Wang X et al. | Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. | 2013 | Biochem. Pharmacol. | pmid:24134913 |
Yu H et al. | Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. | 2013 | PLoS ONE | pmid:24349009 |
Ishii M and Kikuta J | Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. | 2013 | Biochim. Biophys. Acta | pmid:22691949 |
Dziak R | The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. | 2013 | Immunol. Invest. | pmid:24004055 |
Schwalm S et al. | Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. | 2013 | Biochim. Biophys. Acta | pmid:22889995 |
Tran-Dinh A et al. | HDL and endothelial protection. | 2013 | Br. J. Pharmacol. | pmid:23488589 |
Mudd JC et al. | Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. | 2013 | Blood | pmid:23422746 |
Olivera A et al. | Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. | 2013 | J. Leukoc. Biol. | pmid:23904439 |
Camacho L et al. | Acid ceramidase as a therapeutic target in metastatic prostate cancer. | 2013 | J. Lipid Res. | pmid:23423838 |
Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
Kawahara S et al. | Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. | 2013 | Anticancer Drugs | pmid:23426175 |
Yang L et al. | Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. | 2013 | J. Hepatol. | pmid:23466305 |
Reichardt P et al. | A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. | 2013 | EMBO J. | pmid:23443048 |
Natarajan V et al. | Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23449739 |
Hardin C et al. | Glassy dynamics, cell mechanics, and endothelial permeability. | 2013 | J Phys Chem B | pmid:23638866 |
Xiang SY et al. | PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. | 2013 | Sci Signal | pmid:24345679 |
Kendig DM et al. | Sphingosine-1-phosphate induced contraction of bladder smooth muscle. | 2013 | Eur. J. Pharmacol. | pmid:24120660 |
Salmanzadeh A et al. | Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. | 2013 | Integr Biol (Camb) | pmid:23609351 |
Orr Gandy KA et al. | Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. | 2013 | FASEB J. | pmid:23629860 |
Schneider G et al. | Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. | 2013 | Mol. Cancer Res. | pmid:23615526 |
Cinq-Frais C et al. | A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. | 2013 | Biochim. Biophys. Acta | pmid:23651497 |
Christoffersen C and Nielsen LB | Apolipoprotein M: bridging HDL and endothelial function. | 2013 | Curr. Opin. Lipidol. | pmid:23652568 |
Egom EE et al. | HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. | 2013 | Curr. Opin. Lipidol. | pmid:23652570 |
Lundblad C et al. | Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. | 2013 | Acta Anaesthesiol Scand | pmid:23683126 |
Kroetsch JT and Bolz SS | The TNF-α/sphingosine-1-phosphate signaling axis drives myogenic responsiveness in heart failure. | 2013 | J. Vasc. Res. | pmid:23594703 |
Allende ML et al. | Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. | 2013 | J. Biol. Chem. | pmid:23637227 |
Schaper K et al. | Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. | 2013 | J. Dermatol. Sci. | pmid:23643308 |
Böhm A et al. | Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. | 2013 | Cardiovasc. Res. | pmid:23658376 |
Kurano M et al. | Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. | 2013 | Atherosclerosis | pmid:23664237 |
Stradner MH et al. | Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. | 2013 | Arthritis Rheum. | pmid:23666803 |
Usatyuk PV et al. | Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. | 2013 | PLoS ONE | pmid:23667561 |
Starzyńska T et al. | An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. | 2013 | J. Cell. Mol. Med. | pmid:23672538 |
Osawa Y et al. | Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. | 2013 | J. Clin. Invest. | pmid:23298833 |
Xu Y et al. | Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23239501 |
Evindar G et al. | Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23245510 |
Lee YJ et al. | Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. | 2013 | Int. J. Mol. Med. | pmid:23381659 |
Yangyuoru PM et al. | Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. | 2013 | Methods Mol. Biol. | pmid:23386355 |
Dillahunt SE et al. | Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. | 2013 | J. Immunol. | pmid:23359503 |
Tong X et al. | High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. | 2013 | Cardiovasc Diabetol | pmid:23360427 |
Finley A et al. | Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. | 2013 | PLoS ONE | pmid:23372844 |
Del Galdo S et al. | The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. | 2013 | Cell. Signal. | pmid:23993968 |
Gandy KA et al. | Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. | 2013 | Biochem. J. | pmid:23106337 |
Pantoja M et al. | Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. | 2013 | Development | pmid:23154413 |
Takahashi K et al. | Novel therapy for liver regeneration by increasing the number of platelets. | 2013 | Surg. Today | pmid:23180116 |
Lidington D et al. | Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. | 2013 | Cardiovasc. Res. | pmid:23180720 |
Nagahashi M et al. | Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. | 2013 | FASEB J. | pmid:23180825 |
Huang J et al. | Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. | 2013 | Mol. Cell. Endocrinol. | pmid:23127801 |
Carr JM et al. | Sphingosine kinase 1 in viral infections. | 2013 | Rev. Med. Virol. | pmid:22639116 |
Zu Heringdorf DM et al. | Pharmacology of the sphingosine-1-phosphate signalling system. | 2013 | Handb Exp Pharmacol | pmid:23579459 |
Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
Sobel K et al. | Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. | 2013 | J. Biol. Chem. | pmid:23589284 |
Barth BM et al. | Gaucher's disease and cancer: a sphingolipid perspective. | 2013 | Crit Rev Oncog | pmid:23510065 |
Bernhart E et al. | Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. | 2013 | Exp. Cell Res. | pmid:23562655 |
Selvam SP and Ogretmen B | Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. | 2013 | Handb Exp Pharmacol | pmid:23563649 |
Pyne S and Pyne NJ | New perspectives on the role of sphingosine 1-phosphate in cancer. | 2013 | Handb Exp Pharmacol | pmid:23563651 |
Jiang XC and Liu J | Sphingolipid metabolism and atherosclerosis. | 2013 | Handb Exp Pharmacol | pmid:23563655 |
Levkau B | Cardiovascular effects of sphingosine-1-phosphate (S1P). | 2013 | Handb Exp Pharmacol | pmid:23563656 |
Abbasi T and Garcia JG | Sphingolipids in lung endothelial biology and regulation of vascular integrity. | 2013 | Handb Exp Pharmacol | pmid:23563658 |
Gandy KA and Obeid LM | Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. | 2013 | Handb Exp Pharmacol | pmid:23563662 |
Bruni P and Donati C | Role of sphingosine 1-phosphate in skeletal muscle cell biology. | 2013 | Handb Exp Pharmacol | pmid:23563671 |
Vessey DA et al. | FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. | 2013 | Med Sci Monit Basic Res | pmid:23567658 |
Wallington-Beddoe CT et al. | Oncogenic properties of sphingosine kinases in haematological malignancies. | 2013 | Br. J. Haematol. | pmid:23521541 |
Bendall LJ and Basnett J | Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. | 2013 | Curr. Opin. Hematol. | pmid:23507960 |
Erkhembaatar LO et al. | Increased expression of sphingosine kinase in the amnion during labor. | 2013 | Placenta | pmid:23462226 |
Pyne NJ et al. | Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. | 2013 | Biochim. Biophys. Acta | pmid:22801038 |
Park K et al. | Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. | 2013 | J. Invest. Dermatol. | pmid:23856934 |
Lukowski ZL et al. | Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model. | 2013 | J. Glaucoma | pmid:21946553 |
Ohkuni A et al. | Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24269233 |
Zhang J et al. | Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. | 2013 | Hum. Reprod. | pmid:24001716 |
Kihara A | [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. | 2013 | Seikagaku | pmid:23980469 |
Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
Weichand B et al. | Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. | 2013 | Eur. J. Immunol. | pmid:23934754 |
Morad SA et al. | Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. | 2013 | Biochim. Biophys. Acta | pmid:23939396 |
Banitalebi E et al. | The effect of resistance training on plasma S1P level and gene expression of S1P1,2,3 receptors in male Wistar rats. | 2013 | Minerva Endocrinol. | pmid:24285107 |
Rokka J et al. | 19F/18F exchange synthesis for a novel [18F]S1P3-radiopharmaceutical. | 2013 | J Labelled Comp Radiopharm | pmid:24285478 |
Kajimoto T et al. | Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes. | 2013 | Nat Commun | pmid:24231649 |
Ito S et al. | Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. | 2013 | Coron. Artery Dis. | pmid:24212262 |
Lim SH et al. | Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting. | 2013 | Integr Biol (Camb) | pmid:24190477 |
Lamichhane A et al. | Nutritional components regulate the gut immune system and its association with intestinal immune disease development. | 2013 | J. Gastroenterol. Hepatol. | pmid:24251698 |