Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

Cross Reference

Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Acne Vulgaris D000152 35 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fabry Disease D000795 4 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Asthma D001249 52 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Dilatation, Pathologic D004108 5 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Eye Abnormalities D005124 7 associated lipids
Fibrosis D005355 23 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Insulinoma D007340 28 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lung Neoplasms D008175 171 associated lipids
Melanoma D008545 69 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Cardiomyopathies D009202 10 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Ogle ME et al. Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. 2017 Stem Cells pmid:28026131
Yung BS et al. Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. 2017 J. Mol. Cell. Cardiol. pmid:28017639
Contaifer D et al. Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. 2017 J. Lipid Res. pmid:27993949
Myśliwiec H et al. Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. 2017 Arch. Dermatol. Res. pmid:27988894
McLean CJ et al. Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. 2017 J. Lipid Res. pmid:27784725
Abraham C et al. Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. 2017 Gastroenterology pmid:27780712
Vogt D and Stark H Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. 2017 Med Res Rev pmid:27480072
Doan NB et al. Acid ceramidase confers radioresistance to glioblastoma cells. 2017 Oncol. Rep. pmid:28765947
Arish M et al. Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. 2017 J. Recept. Signal Transduct. Res. pmid:28758826
Polzin A et al. Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. 2017 J. Mol. Cell. Cardiol. pmid:28709768
Innamorati G et al. Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. 2017 Cell Death Dis pmid:28703804
Bougault C et al. Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. 2017 Bone pmid:28684192
Tsai CH et al. Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. 2017 Mol Oncol pmid:28672103
Schmidt KG et al. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. 2017 Front Immunol pmid:29033951
Xie Z et al. Targeting sphingosine-1-phosphate signaling for cancer therapy. 2017 Sci China Life Sci pmid:28623546
Yanagida K et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:28396408
Takahashi C et al. Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. 2017 J. Atheroscler. Thromb. pmid:28321011
Pierucci F et al. Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. 2017 Neuropharmacology pmid:28077289
Leo A et al. The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. 2017 CNS Neurol Disord Drug Targets pmid:27823573
Vu TM et al. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. 2017 Nature pmid:29045386
Reinhard NR et al. The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. 2017 Mol. Biol. Cell pmid:28954861
Natarajan V et al. Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. 2017 BMC Genomics pmid:28851267
Hajny S and Christoffersen C A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. 2017 Int J Mol Sci pmid:28749426
Alqinyah M et al. Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. 2017 Mol. Pharmacol. pmid:28031332
Winkler MS et al. Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? 2017 Shock pmid:27922551
Chen T et al. Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. 2017 Front Biosci (Landmark Ed) pmid:27814635
Beider K et al. The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. 2017 Clin. Cancer Res. pmid:27697999
Feuerborn R et al. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. 2017 Atherosclerosis pmid:28038379
Thieme M et al. Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. 2017 Exp. Dermatol. pmid:27574180
Chang N et al. HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. 2017 J. Mol. Med. pmid:27543493
Gudipaty SA and Rosenblatt J Epithelial cell extrusion: Pathways and pathologies. 2017 Semin. Cell Dev. Biol. pmid:27212253
Werth S et al. Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. 2017 J. Endocrinol. pmid:28970286
Du Y et al. Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. 2017 Cell. Physiol. Biochem. pmid:28934733
Kuchler L et al. Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. 2017 Mol. Immunol. pmid:28846923
Nicholas SE et al. Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. 2017 PLoS ONE pmid:28806736
Lee SY et al. Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. 2017 Diabetes pmid:28698261
Hutami IR et al. Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. 2017 Biochem. Biophys. Res. Commun. pmid:28687489
Cannavo A et al. β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. 2017 J. Am. Coll. Cardiol. pmid:28683966
Punsawad C and Viriyavejakul P Reduction in serum sphingosine 1-phosphate concentration in malaria. 2017 PLoS ONE pmid:28666023
Luo J et al. The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. 2017 Biochem. Biophys. Res. Commun. pmid:28655617
Chang CH and Randolph GJ Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. 2017 Dev. Cell pmid:28633013
Fang R et al. Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. 2017 Arch. Med. Res. pmid:28625317
Andrieu G et al. Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. 2017 Sci Signal pmid:28351953
Becker S et al. Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. 2017 PLoS ONE pmid:28334008
Karunakaran I and van Echten-Deckert G Sphingosine 1-phosphate - A double edged sword in the brain. 2017 Biochim. Biophys. Acta pmid:28315304
Navarrete A et al. A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. 2017 J Pharm Biomed Anal pmid:28314215
Shirakawa H et al. Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. 2017 Glia pmid:28300348
Dyckman AJ Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. 2017 J. Med. Chem. pmid:28291340
Nielsen OH et al. Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. 2017 Trends Mol Med pmid:28283249
Peyrin-Biroulet L et al. Modulation of sphingosine-1-phosphate in inflammatory bowel disease. 2017 Autoimmun Rev pmid:28279838
Miller M et al. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. 2017 J. Immunol. pmid:28275141
Tafelmeier M et al. Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. 2017 J. Steroid Biochem. Mol. Biol. pmid:27163393
Su K et al. FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. 2017 Mediators Inflamm. pmid:28270699
Serafimidis I et al. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. 2017 PLoS Biol. pmid:28248965
Lee HM et al. Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. 2017 J. Pathol. pmid:28240350
Fu P et al. Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. 2016 J. Biol. Chem. pmid:27864331
Wang X et al. Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. 2016 PLoS Pathog. pmid:27711202
Adamiak M et al. The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. 2016 Stem Cell Rev pmid:27704316
Morillon YM et al. Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. 2016 J. Immunol. pmid:27694496
Zhang Q et al. Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. 2016 Am. J. Chin. Med. pmid:27430910
Adamiak M et al. Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. 2016 Cell Transplant pmid:27412411
Liu X et al. ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. 2016 J. Physiol. Biochem. pmid:27377933
Egom EE et al. Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. 2016 Mol. Cell. Biochem. pmid:27372350
Sanagawa A et al. Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. 2016 Mol Med Rep pmid:27357063
Tiper IV et al. Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. 2016 Pathog Dis pmid:27354294
Tong S et al. Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. 2016 J. Biol. Chem. pmid:27405756
Cai Y et al. FOXF1 maintains endothelial barrier function and prevents edema after lung injury. 2016 Sci Signal pmid:27095594
Castaldi A et al. Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. 2016 Cell. Signal. pmid:27094722
Anbazhagan AN et al. Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:27079615
Koresawa R et al. Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. 2016 Br. J. Haematol. pmid:27061580
Resop RS et al. Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery. 2016 J. Allergy Clin. Immunol. pmid:27056271
Guo J et al. Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). 2016 Bioorg. Med. Chem. Lett. pmid:27055941
Adams DR et al. Sphingosine Kinases: Emerging Structure-Function Insights. 2016 Trends Biochem. Sci. pmid:27021309
Lv M et al. Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. 2016 Inflamm. Res. pmid:27002656
Wang H et al. Potential serum biomarkers from a metabolomics study of autism. 2016 J Psychiatry Neurosci pmid:26395811
Zhang H et al. Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. 2016 Sci Rep pmid:27476912
Kim SE et al. The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. 2016 Invest. Ophthalmol. Vis. Sci. pmid:26830367
Messias CV et al. Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. 2016 PLoS ONE pmid:26824863
Pászti-Gere E et al. Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. 2016 Oxid Med Cell Longev pmid:26823955
Wiltshire R et al. Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. 2016 Sci Rep pmid:26813587
Farez MF and Correale J Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis. 2016 J. Neurol. Sci. pmid:26810518
Santos-Cortez RL et al. Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. 2016 Am. J. Hum. Genet. pmid:26805784
Bock S et al. Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. 2016 J. Dermatol. Sci. pmid:26803226
Marycz K et al. The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro. 2016 J Biomater Appl pmid:26801473
Zhang F et al. Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. 2016 Am. J. Physiol. Heart Circ. Physiol. pmid:26589326
Pyne NJ and Tigyi GJ A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. 2016 Prog. Lipid Res. pmid:26584871
Rana A and Sharma S Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. 2016 Clin. Exp. Pharmacol. Physiol. pmid:26582369
Yuasa D et al. C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. 2016 FASEB J. pmid:26578687
Patmanathan SN et al. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. 2016 Sci Rep pmid:27160553
Li N and Zhang F Implication of sphingosin-1-phosphate in cardiovascular regulation. 2016 Front Biosci (Landmark Ed) pmid:27100508
Ratajczak MZ and Suszynska M Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. 2016 Stem Cell Rev pmid:26400757
Zhang L et al. Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. 2016 Microcirculation pmid:27015105
Yaghobian D et al. Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. 2016 Clin. Exp. Pharmacol. Physiol. pmid:26414003
Bae SJ et al. The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. 2016 Osteoporos Int pmid:26984570
Kalhori V et al. FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. 2016 Endocr. Relat. Cancer pmid:26935838
Setoguchi R IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. 2016 Int. Immunol. pmid:26857736
Nojima H et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. 2016 J. Hepatol. pmid:26254847
Kim BJ et al. The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. 2016 J. Endocrinol. Invest. pmid:26219613
Touat-Hamici Z et al. Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. 2016 Cardiovasc. Res. pmid:27694435
Medina CB and Ravichandran KS Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. 2016 Cell Death Differ. pmid:26891690