Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsia K et al. | Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. | 2017 | Acta Biomater | pmid:28110073 |
| Mao-Draayer Y et al. | The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. | 2017 | Clin. Immunol. | pmid:27890706 |
| Lee MH et al. | S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. | 2017 | J. Lipid Res. | pmid:27881715 |
| Ruiz M et al. | High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:27879252 |
| Barnawi J et al. | Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. | 2017 | Respirology | pmid:27868302 |
| Frias MA et al. | High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. | 2017 | Eur. J. Clin. Invest. | pmid:27861771 |
| Fang V et al. | Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. | 2017 | Nat. Immunol. | pmid:27841869 |
| Wang R et al. | Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. | 2017 | Am. J. Pathol. | pmid:27840081 |
| Engel N et al. | Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. | 2017 | PLoS ONE | pmid:28125641 |
| Vogt D and Stark H | Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. | 2017 | Med Res Rev | pmid:27480072 |
| Arish M et al. | Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28758826 |
| Polzin A et al. | Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. | 2017 | J. Mol. Cell. Cardiol. | pmid:28709768 |
| Innamorati G et al. | Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. | 2017 | Cell Death Dis | pmid:28703804 |
| Bougault C et al. | Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. | 2017 | Bone | pmid:28684192 |
| Tsai CH et al. | Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. | 2017 | Mol Oncol | pmid:28672103 |
| Schmidt KG et al. | Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. | 2017 | Front Immunol | pmid:29033951 |
| Xie Z et al. | Targeting sphingosine-1-phosphate signaling for cancer therapy. | 2017 | Sci China Life Sci | pmid:28623546 |
| Yanagida K et al. | Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28396408 |
| Takahashi C et al. | Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. | 2017 | J. Atheroscler. Thromb. | pmid:28321011 |
| Pierucci F et al. | Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. | 2017 | Neuropharmacology | pmid:28077289 |
| Leo A et al. | The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. | 2017 | CNS Neurol Disord Drug Targets | pmid:27823573 |
| Vu TM et al. | Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. | 2017 | Nature | pmid:29045386 |
| Reinhard NR et al. | The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. | 2017 | Mol. Biol. Cell | pmid:28954861 |
| Natarajan V et al. | Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. | 2017 | BMC Genomics | pmid:28851267 |
| Hajny S and Christoffersen C | A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. | 2017 | Int J Mol Sci | pmid:28749426 |
| Kurano M et al. | Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. | 2017 | PLoS ONE | pmid:28494002 |
| Al-Jarallah A and Oriowo M | The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. | 2017 | PLoS ONE | pmid:28493876 |
| Chen T et al. | Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. | 2017 | Front Biosci (Landmark Ed) | pmid:27814635 |
| Beider K et al. | The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. | 2017 | Clin. Cancer Res. | pmid:27697999 |
| Thieme M et al. | Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. | 2017 | Exp. Dermatol. | pmid:27574180 |
| Chang N et al. | HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. | 2017 | J. Mol. Med. | pmid:27543493 |
| Gudipaty SA and Rosenblatt J | Epithelial cell extrusion: Pathways and pathologies. | 2017 | Semin. Cell Dev. Biol. | pmid:27212253 |
| Mendoza A et al. | Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. | 2017 | Nature | pmid:28538737 |
| Ma S et al. | A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. | 2017 | Dev. Cell | pmid:28535372 |
| Meshcheryakova A et al. | Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. | 2017 | Expert Opin. Ther. Targets | pmid:28524744 |
| Ko J et al. | Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28492873 |
| Aoyama-Araki Y et al. | Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28418499 |
| Frej C et al. | A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28385702 |
| Nakajima M et al. | The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. | 2017 | Tumour Biol. | pmid:28381169 |
| Garbowska M et al. | Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes. | 2017 | J. Cell. Physiol. | pmid:28369933 |
| Tafelmeier M et al. | Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27163393 |
| Ren K et al. | ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. | 2017 | J. Physiol. Biochem. | pmid:28181168 |
| Ruiz M et al. | HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. | 2017 | Lipids Health Dis | pmid:28179022 |
| Moruno-Manchon JF et al. | Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. | 2017 | Hum. Mol. Genet. | pmid:28175299 |
| Rojas-Canales D et al. | Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. | 2017 | Diabetes | pmid:28174291 |
| Dela Paz NG et al. | Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. | 2017 | Am. J. Physiol., Cell Physiol. | pmid:28148497 |
| Green CL et al. | The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. | 2017 | Aging Cell | pmid:28139067 |
| Vishwakarma S et al. | Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. | 2017 | Cancer Invest. | pmid:28135860 |
| Kurano M et al. | Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28126827 |
| Wang Y et al. | The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. | 2017 | Hepatology | pmid:28120434 |