Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kolahdooz Z et al. | Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. | 2015 | Can J Neurol Sci | pmid:25860537 |
Ren K et al. | Apolipoprotein M. | 2015 | Clin. Chim. Acta | pmid:25858547 |
Molinari G | Is hydrogen ion (H(+)) the real second messenger in calcium signalling? | 2015 | Cell. Signal. | pmid:25843778 |
Nussbaum C et al. | Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. | 2015 | Nat Commun | pmid:25832730 |
Riley RT et al. | A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. | 2015 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:25833119 |
Proia RL and Hla T | Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. | 2015 | J. Clin. Invest. | pmid:25831442 |
Lee SY et al. | Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. | 2015 | Hepatology | pmid:25808625 |
Salama MF et al. | A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. | 2015 | FASEB J. | pmid:25805832 |
Potì F et al. | SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. | 2015 | Atherosclerosis | pmid:25801013 |
Hsu CK et al. | Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. | 2015 | J. Cell. Physiol. | pmid:25201048 |
Liu M et al. | Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. | 2015 | J. Biol. Chem. | pmid:25627684 |
Hwang IY et al. | An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. | 2015 | J. Immunol. | pmid:25617475 |
Mikłosz A et al. | Hyperthyroidism evokes myocardial ceramide accumulation. | 2015 | Cell. Physiol. Biochem. | pmid:25613909 |
Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
Chen LY et al. | The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells. | 2015 | Nat Commun | pmid:25591940 |
Zhang L et al. | Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. | 2015 | Clin. Cancer Res. | pmid:25589614 |
Chavez A et al. | S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. | 2015 | J. Cell. Sci. | pmid:25588843 |
Woszczek G and Fuerst E | Ca2+ mobilization assays in GPCR drug discovery. | 2015 | Methods Mol. Biol. | pmid:25563178 |
Li Q et al. | Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells. | 2015 | Exp. Physiol. | pmid:25557733 |
Chawla S and Saxena S | Differential modulation of S1PR(1-5) and specific activities of SphK and nSMase in pulmonary and cerebral tissues of rats exposed to hypobaric hypoxia. | 2015 | Lipids | pmid:25398597 |
Santos WL and Lynch KR | Drugging sphingosine kinases. | 2015 | ACS Chem. Biol. | pmid:25384187 |
Sar JI et al. | Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. | 2015 | J. Formos. Med. Assoc. | pmid:24035571 |
Kurek K et al. | Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. | 2015 | J Diabetes Res | pmid:26380311 |
Cuvillier O | [SphingomabTM, an anti-sphingosine 1-phosphate antibody to inhibit hypoxia]. | 2015 | Med Sci (Paris) | pmid:26576602 |
Moon E et al. | Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. | 2015 | Mediators Inflamm. | pmid:26576074 |
Tang H et al. | Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. | 2015 | Acta Cir Bras | pmid:26560422 |
Zhao C et al. | Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts. | 2015 | Mediators Inflamm. | pmid:26556954 |
Wang Z et al. | Decreased Splenic CD4(+) T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. | 2015 | Biomed Res Int | pmid:26543853 |
Sattler K et al. | Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-Loading. | 2015 | J. Am. Coll. Cardiol. | pmid:26403344 |
Scanlon KM et al. | Novel therapies for the treatment of pertussis disease. | 2015 | Pathog Dis | pmid:26394802 |
Frej C et al. | Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation. | 2015 | Anal Bioanal Chem | pmid:26377937 |
Klyachkin YM et al. | Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. | 2015 | Stem Cells Transl Med | pmid:26371341 |
Yester JW et al. | Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. | 2015 | FASEB J. | pmid:26246404 |
Kharel Y et al. | Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26243740 |
Gao XY et al. | Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications. | 2015 | Oncol. Rep. | pmid:26239167 |
Adada MM et al. | Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. | 2015 | FASEB J. | pmid:26209696 |
Wang H et al. | Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-β. | 2015 | Cell. Mol. Biol. Lett. | pmid:26208383 |
Manes NP et al. | Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. | 2015 | Mol. Cell Proteomics | pmid:26199343 |
Spampinato SF et al. | Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? | 2015 | PLoS ONE | pmid:26197437 |
Airola MV et al. | Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. | 2015 | Structure | pmid:26190575 |
Zhang JN et al. | The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction. | 2015 | Bone | pmid:25988659 |
Parham KA et al. | Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. | 2015 | FASEB J. | pmid:25985799 |
Schweitzer KS et al. | Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25979079 |
Lee KP et al. | DJ-1-mediated upregulation of serine palmitoyltransferase 2 controls vascular neointima via S1P autocrine. | 2015 | Int. J. Cardiol. | pmid:25978603 |
Morad SA and Cabot MC | Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications. | 2015 | Biochim. Biophys. Acta | pmid:25964209 |
Jing XD et al. | The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis. | 2015 | Clin. Chim. Acta | pmid:25958848 |
Laurenzana A et al. | Endothelial sphingosine kinase/SPNS2 axis is critical for vessel-like formation by human mesoangioblasts. | 2015 | J. Mol. Med. | pmid:25952146 |
Rahman MM et al. | Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25951977 |
Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |
Prager B et al. | Sphingosine 1-phosphate signaling at the blood-brain barrier. | 2015 | Trends Mol Med | pmid:25939882 |