Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brünnert D et al. | Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. | 2014 | Mol. Hum. Reprod. | pmid:24994816 |
| Di Pietro M et al. | In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. | 2017 | Mol. Hum. Reprod. | pmid:28379469 |
| Goyal P et al. | Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. | 2013 | Mol. Hum. Reprod. | pmid:23538947 |
| Scotti L et al. | Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. | 2016 | Mol. Hum. Reprod. | pmid:27645281 |
| Wilson PC et al. | Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. | 2015 | Mol. Endocrinol. | pmid:25871850 |
| El-Shewy HM et al. | Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. | 2012 | Mol. Endocrinol. | pmid:22422617 |
| Frati A et al. | Role of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxin. | 2015 | Mol. Endocrinol. | pmid:25415609 |
| Yagoub D et al. | Sphingosine kinase 1 isoform-specific interactions in breast cancer. | 2014 | Mol. Endocrinol. | pmid:25216046 |
| Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
| El-Shewy HM et al. | Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. | 2011 | Mol. Endocrinol. | pmid:22016563 |
| Ishii T et al. | The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. | 2011 | Mol. Cells | pmid:21360199 |
| Nam JH et al. | Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. | 2010 | Mol. Cells | pmid:20069383 |
| Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23307289 |
| Song HJ et al. | Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. | 2006 | Mol. Cells | pmid:16511346 |
| Kalhori V and Törnquist K | MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. | 2015 | Mol. Cell. Endocrinol. | pmid:25643979 |
| Chen C et al. | Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. | 2016 | Mol. Cell. Endocrinol. | pmid:26948947 |
| Lucki NC et al. | Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. | 2012 | Mol. Cell. Endocrinol. | pmid:21864647 |
| Björklund S et al. | Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. | 2005 | Mol. Cell. Endocrinol. | pmid:15713536 |
| Huang J et al. | Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. | 2013 | Mol. Cell. Endocrinol. | pmid:23127801 |
| Takuwa Y et al. | Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. | 2001 | Mol. Cell. Endocrinol. | pmid:11377814 |
| Hadizadeh S et al. | Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. | 2008 | Mol. Cell. Endocrinol. | pmid:18191017 |
| Kohno M et al. | Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. | 2006 | Mol. Cell. Biol. | pmid:16980623 |
| Miller AV et al. | Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. | 2008 | Mol. Cell. Biol. | pmid:18426913 |
| Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
| Kim YI et al. | An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. | 2014 | Mol. Cell. Biol. | pmid:25312644 |
| Serafimidis I et al. | G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. | 2011 | Mol. Cell. Biol. | pmid:21911471 |
| Mizugishi K et al. | Essential role for sphingosine kinases in neural and vascular development. | 2005 | Mol. Cell. Biol. | pmid:16314531 |
| Okamoto H et al. | Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. | 2000 | Mol. Cell. Biol. | pmid:11094076 |
| Tellier E et al. | Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. | 2007 | Mol. Cell. Biol. | pmid:17283058 |
| Park K et al. | A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. | 2013 | Mol. Cell. Biol. | pmid:23230267 |
| Campos LS et al. | Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. | 2016 | Mol. Cell. Biol. | pmid:26552704 |
| Kajimoto T et al. | Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. | 2007 | Mol. Cell. Biol. | pmid:17325039 |
| Long JS et al. | Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. | 2010 | Mol. Cell. Biol. | pmid:20516217 |
| Desai P et al. | Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis. | 2015 | Mol. Cell. Biochem. | pmid:26350564 |
| Liu X et al. | Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. | 2012 | Mol. Cell. Biochem. | pmid:22113622 |
| Hashimoto Y et al. | Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. | 2015 | Mol. Cell. Biochem. | pmid:25445169 |
| Lu H et al. | Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. | 2012 | Mol. Cell. Biochem. | pmid:22139303 |
| Egom EE et al. | Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. | 2016 | Mol. Cell. Biochem. | pmid:27372350 |
| Schmitz EI et al. | Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. | 2012 | Mol. Cell. Biochem. | pmid:22899173 |
| Rapizzi E et al. | Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. | 2008 | Mol. Cell. Biochem. | pmid:18454302 |
| Harvey KA et al. | Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. | 2010 | Mol. Cell. Biochem. | pmid:20401628 |
| Furukawa A et al. | Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds. | 2007 | Mol. Cell. Biochem. | pmid:17577630 |
| Guo Y et al. | Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | 2007 | Mol. Cell Proteomics | pmid:17210631 |
| Manes NP et al. | Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. | 2015 | Mol. Cell Proteomics | pmid:26199343 |
| Gottlieb D et al. | The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. | 1999 | Mol. Cell Biol. Res. Commun. | pmid:10329480 |
| Lee MJ et al. | Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | 2001 | Mol. Cell | pmid:11583630 |
| Nakahara K et al. | The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. | 2012 | Mol. Cell | pmid:22633490 |
| Annabi B et al. | Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. | 2009 | Mol. Carcinog. | pmid:19326372 |
| Wang D et al. | S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. | 2008 | Mol. Cancer Ther. | pmid:18645009 |
| Pchejetski D et al. | Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. | 2008 | Mol. Cancer Ther. | pmid:18644996 |