Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
Tanaka K et al. | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. | 2014 | Clin. Exp. Immunol. | pmid:24028747 |
Kihara A | Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. | 2014 | Biochim. Biophys. Acta | pmid:23994042 |
Moxon JV et al. | Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. | 2014 | Circ Cardiovasc Genet | pmid:24448739 |
Gorlino CV et al. | Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes. | 2014 | J. Immunol. | pmid:25015824 |
Anderson G and Maes M | Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. | 2014 | CNS Neurol Disord Drug Targets | pmid:24040808 |
Waeber C and Walther T | Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction. | 2014 | Circ. J. | pmid:24632793 |
Brünnert D et al. | Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. | 2014 | Mol. Hum. Reprod. | pmid:24994816 |
Willinger T et al. | Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. | 2014 | J. Exp. Med. | pmid:24638168 |
Purschke WG et al. | Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. | 2014 | Biochem. J. | pmid:24832383 |
Karaca I et al. | Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. | 2014 | J. Biol. Chem. | pmid:24808180 |
Fayyaz S et al. | Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. | 2014 | Diabetologia | pmid:24292566 |
Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
Shimizu Y et al. | Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. | 2014 | Am. J. Pathol. | pmid:24641902 |
Langeslag M et al. | Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. | 2014 | Mol Pain | pmid:25431213 |
Callihan P et al. | Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. | 2014 | ASN Neuro | pmid:25424429 |
Kułakowska A et al. | Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. | 2014 | J Neuroinflammation | pmid:25421616 |
Slattum G et al. | Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. | 2014 | Curr. Biol. | pmid:24361067 |
Gomes L et al. | Sphingosine 1-phosphate in acute dengue infection. | 2014 | PLoS ONE | pmid:25409037 |
Miller DS | Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24385389 |
Xu M et al. | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. | 2014 | Acta Pharmacol. Sin. | pmid:25399649 |
Watanabe C et al. | Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. | 2014 | Langmuir | pmid:25386673 |
Dai L et al. | Sphingosine 1-phosphate: a potential molecular target for ovarian cancer therapy? | 2014 | Cancer Invest. | pmid:24499107 |
Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
Nakajima C et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. | 2014 | Development | pmid:25377550 |
Takeshita E et al. | Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24486543 |
Barnes J and Dweik RA | Is pulmonary hypertension a metabolic disease? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25360726 |
Kamiya T et al. | Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. | 2014 | Exp. Eye Res. | pmid:24486793 |
Chen J et al. | Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. | 2014 | PLoS Genet. | pmid:25356849 |
Plano D et al. | Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. | 2014 | J. Med. Chem. | pmid:24471412 |
Nakamura H and Murayama T | Role of sphingolipids in arachidonic acid metabolism. | 2014 | J. Pharmacol. Sci. | pmid:24599139 |
Guo S et al. | Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. | 2014 | Biochim. Biophys. Acta | pmid:24603322 |
Kempf A et al. | The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. | 2014 | PLoS Biol. | pmid:24453941 |
Tao C et al. | Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. | 2014 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:24417945 |
Hamidi S et al. | TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. | 2014 | Biochim. Biophys. Acta | pmid:24440818 |
Park K et al. | The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. | 2014 | J. Nutr. Biochem. | pmid:24768661 |
Schaper K et al. | Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. | 2014 | Mol. Immunol. | pmid:24434636 |
Kono M et al. | Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. | 2014 | J. Clin. Invest. | pmid:24667638 |
Sasaki H et al. | Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. | 2014 | Arch. Biochem. Biophys. | pmid:24708996 |
Sutter I et al. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. | 2014 | J. Lipid Res. | pmid:24950692 |
Xiong Y et al. | Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. | 2014 | J. Clin. Invest. | pmid:25250575 |
Tan SJ et al. | Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. | 2014 | Reprod. Biomed. Online | pmid:25246113 |
Goñi FM et al. | Biophysical properties of sphingosine, ceramides and other simple sphingolipids. | 2014 | Biochem. Soc. Trans. | pmid:25233422 |
Yagoub D et al. | Sphingosine kinase 1 isoform-specific interactions in breast cancer. | 2014 | Mol. Endocrinol. | pmid:25216046 |
Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
Chen J et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25180446 |
Kong Y et al. | Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. | 2014 | Mediators Inflamm. | pmid:25147438 |
Shayegi N et al. | CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model. | 2014 | Br. J. Haematol. | pmid:24180707 |
Nagahashi M et al. | Sphingosine-1-phosphate transporters as targets for cancer therapy. | 2014 | Biomed Res Int | pmid:25133174 |
Nguyen AV et al. | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. | 2014 | World J. Gastroenterol. | pmid:25132744 |
Kim ES et al. | Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. | 2014 | Oncogene | pmid:23955082 |
St John AL et al. | S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. | 2014 | Immunity | pmid:25238098 |
Davis KM and Isberg RR | Plague's partners in crime. | 2014 | Immunity | pmid:25238090 |
Wakashima T et al. | Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. | 2014 | J. Biol. Chem. | pmid:25049234 |
Marfia G et al. | Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. | 2014 | Glia | pmid:25042636 |
Fuerst E et al. | Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. | 2014 | Allergy | pmid:25041788 |
Murakami M et al. | Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. | 2014 | Acta Biomater | pmid:25038462 |
Park SJ et al. | Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. | 2014 | Cell. Signal. | pmid:25035231 |
Kim EY et al. | Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. | 2014 | FASEB J. | pmid:25002116 |
Schwalm S et al. | Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:23789924 |
Hao J et al. | The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. | 2014 | Arthritis Res. Ther. | pmid:25000985 |
Tsai YC et al. | Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. | 2014 | Reprod Sci | pmid:23793475 |
Rauch BH | Sphingosine 1-phosphate as a link between blood coagulation and inflammation. | 2014 | Cell. Physiol. Biochem. | pmid:24977491 |
Sattler K et al. | HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977490 |
Thuy AV et al. | Sphingosine 1-phosphate in blood: function, metabolism, and fate. | 2014 | Cell. Physiol. Biochem. | pmid:24977489 |
van Echten-Deckert G et al. | Sphingosine-1-phosphate: boon and bane for the brain. | 2014 | Cell. Physiol. Biochem. | pmid:24977488 |
Fayyaz S et al. | Divergent role of sphingosine 1-phosphate on insulin resistance. | 2014 | Cell. Physiol. Biochem. | pmid:24977487 |
Halmer R et al. | Sphingolipids: important players in multiple sclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977485 |
BÅ‚ogowski W et al. | Perioperative release of pro-regenerative biochemical signals from human renal allografts subjected to ischemia-reperfusion injury. | 2014 | Innate Immun | pmid:23608824 |
Brizuela L et al. | Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. | 2014 | Mol Oncol | pmid:24768038 |
Poitevin S et al. | Sphingosine kinase 1 expressed by endothelial colony-forming cells has a critical role in their revascularization activity. | 2014 | Cardiovasc. Res. | pmid:24743591 |
Mahajan-Thakur S et al. | Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. | 2014 | J. Leukoc. Biol. | pmid:24990321 |
O'Sullivan MJ et al. | Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. | 2014 | PLoS ONE | pmid:24743449 |
Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
Zhu Y et al. | Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. | 2014 | Mol. Neurobiol. | pmid:24722820 |
Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |
Korbelik M et al. | Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. | 2014 | Int. Immunopharmacol. | pmid:24713544 |
Gatfield J et al. | Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. | 2014 | Cell. Signal. | pmid:24704119 |
Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
Yu H et al. | Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. | 2014 | Injury | pmid:24685054 |
Sykes DA et al. | Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. | 2014 | Br. J. Pharmacol. | pmid:24641481 |
Blaho VA and Hla T | An update on the biology of sphingosine 1-phosphate receptors. | 2014 | J. Lipid Res. | pmid:24459205 |
Guo L et al. | Roles of sphingosine-1-phosphate in reproduction. | 2014 | Reprod Sci | pmid:24336672 |
Shen Z et al. | Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). | 2014 | Cell Stress Chaperones | pmid:24293320 |
Chen JJ et al. | Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. | 2014 | Steroids | pmid:24269742 |
Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
Egom EE | Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. | 2014 | J Cardiovasc Med (Hagerstown) | pmid:23839592 |
Jensen T et al. | The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25442311 |
Ye C et al. | Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24633425 |
Pyszko J and Strosznajder JB | Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | 2014 | Mol. Neurobiol. | pmid:24399507 |
Fincher J et al. | G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. | 2014 | Dev. Neurosci. | pmid:25138637 |
Neuber C et al. | Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. | 2014 | Anal. Chem. | pmid:25137547 |
Nishi T et al. | Molecular and physiological functions of sphingosine 1-phosphate transporters. | 2014 | Biochim. Biophys. Acta | pmid:23921254 |
Xia JY et al. | The adipokine/ceramide axis: key aspects of insulin sensitization. | 2014 | Biochimie | pmid:23969158 |