Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Payne SG et al. | Sphingosine-1-phosphate: dual messenger functions. | 2002 | FEBS Lett. | pmid:12401202 |
| Lampasso JD et al. | Role of protein kinase C alpha in primary human osteoblast proliferation. | 2002 | J. Bone Miner. Res. | pmid:12412804 |
| Högback S et al. | Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. | 2003 | Biochem. J. | pmid:12416995 |
| Napier JA et al. | A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. | 2002 | Trends Plant Sci. | pmid:12417141 |
| Nava VE et al. | Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. | 2002 | Exp. Cell Res. | pmid:12441135 |
| Tanski W et al. | Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. | 2002 | J. Surg. Res. | pmid:12443721 |
| Osada M et al. | Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12445827 |
| Grey A et al. | The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. | 2002 | Endocrinology | pmid:12446603 |
| Graeler M and Goetzl EJ | Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. | 2002 | FASEB J. | pmid:12468451 |
| Malchinkhuu E et al. | Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. | 2003 | Biochem. J. | pmid:12470300 |
| Waters C et al. | Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. | 2003 | J. Biol. Chem. | pmid:12480944 |
| Lim HS et al. | Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12482430 |
| Shikata Y et al. | S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. | 2003 | J. Appl. Physiol. | pmid:12482769 |
| Auge N et al. | Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12482824 |
| Katsuma S et al. | Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. | 2002 | Genes Cells | pmid:12485162 |
| Yun JK and Kester M | Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. | 2002 | Arch. Biochem. Biophys. | pmid:12485605 |
| Jeng YJ et al. | Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. | 2003 | Endocrinology | pmid:12488330 |
| Hirafuji M et al. | [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491784 |
| Muraki K et al. | [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. | 2002 | Nippon Yakurigaku Zasshi | pmid:12491795 |
| Benaud CM et al. | Deregulated activation of matriptase in breast cancer cells. | 2002 | Clin. Exp. Metastasis | pmid:12498394 |
| Katsuma S et al. | Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12504122 |
| Yamagata K et al. | Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. | 2003 | Glia | pmid:12509810 |
| Cho H et al. | Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. | 2003 | FASEB J. | pmid:12514120 |
| Meacci E et al. | Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. | 2003 | Biochemistry | pmid:12525155 |
| Florio T et al. | Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. | 2003 | Mol. Pharmacol. | pmid:12527801 |
| Cuvillier O | Sphingosine in apoptosis signaling. | 2002 | Biochim. Biophys. Acta | pmid:12531549 |
| Maceyka M et al. | Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. | 2002 | Biochim. Biophys. Acta | pmid:12531554 |
| Young KW and Nahorski SR | Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. | 2002 Nov-Dec | Cell Calcium | pmid:12543093 |
| Ikeda H et al. | Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. | 2003 | Gastroenterology | pmid:12557151 |
| Rábano M et al. | Sphingosine-1-phosphate stimulates cortisol secretion. | 2003 | FEBS Lett. | pmid:12560086 |
| Cho H et al. | The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. | 2003 | Biochem. J. | pmid:12564955 |
| Ignatov A et al. | Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. | 2003 | J. Neurosci. | pmid:12574419 |
| Dolezalova H et al. | Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. | 2003 | J. Cell. Biochem. | pmid:12577307 |
| Kihara A et al. | Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm. | 2003 | J. Biol. Chem. | pmid:12584204 |
| Jin Y et al. | Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. | 2003 | Blood | pmid:12586615 |
| Osada M et al. | Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | 2002 | Thromb. Res. | pmid:12590954 |
| Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
| Perry DK and Kolesnick RN | Ceramide and sphingosine 1-phosphate in anti-cancer therapies. | 2003 | Cancer Treat. Res. | pmid:12613204 |
| Deroanne C et al. | EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. | 2003 | J. Cell. Sci. | pmid:12615978 |
| Renault AD et al. | Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. | 2002 | Gene Expr. Patterns | pmid:12617823 |
| Fueller M et al. | Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. | 2003 | Cell. Signal. | pmid:12618211 |
| Niedernberg A et al. | Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | 2003 | Cell. Signal. | pmid:12618218 |
| Honig SM et al. | FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. | 2003 | J. Clin. Invest. | pmid:12618517 |
| Schaphorst KL et al. | Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12626332 |
| Malik ZA et al. | Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. | 2003 | J. Immunol. | pmid:12626530 |
| Hakogi T et al. | Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639553 |
| Vogler R et al. | Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. | 2003 | J. Invest. Dermatol. | pmid:12648236 |
| Bollag WB | Paradoxical effects of sphingosine-1-phosphate. | 2003 | J. Invest. Dermatol. | pmid:12648243 |
| Uhlenbrock K et al. | Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. | 2003 | Cell. Physiol. Biochem. | pmid:12649592 |
| Gómez-Muñoz A et al. | Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. | 2003 | FEBS Lett. | pmid:12650926 |