Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hamidi Shishavan M et al. | Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. | 2016 | PLoS ONE | pmid:27583547 |
| Gazit SL et al. | Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. | 2016 | Circ. Res. | pmid:27582371 |
| Machida T et al. | Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. | 2016 | J. Pharmacol. Sci. | pmid:27581589 |
| Thieme M et al. | Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. | 2017 | Exp. Dermatol. | pmid:27574180 |
| Nagahashi M et al. | High levels of sphingolipids in human breast cancer. | 2016 | J. Surg. Res. | pmid:27565080 |
| Sasset L et al. | Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. | 2016 | Trends Endocrinol. Metab. | pmid:27562337 |
| Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
| Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
| Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
| Chang N et al. | HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. | 2017 | J. Mol. Med. | pmid:27543493 |
| Van Veldhoven PP et al. | A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. | 1989 | J. Lipid Res. | pmid:2754341 |
| Harris CM et al. | Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27519818 |
| Gstalder C et al. | FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. | 2016 | Mol. Cancer Ther. | pmid:27507852 |
| Al Alam N and Kreydiyyeh SI | FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. | 2016 | Biochem. Cell Biol. | pmid:27501354 |
| Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
| Vogt D and Stark H | Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. | 2017 | Med Res Rev | pmid:27480072 |
| Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
| Viswanathan P et al. | Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27473658 |
| Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
| Evangelisti C et al. | Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. | 2016 | Leukemia | pmid:27461062 |
| Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
| Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
| Poissonnier A et al. | CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. | 2016 | Immunity | pmid:27438772 |
| Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
| Adamiak M et al. | Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. | 2016 | Cell Transplant | pmid:27412411 |
| Tong S et al. | Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. | 2016 | J. Biol. Chem. | pmid:27405756 |
| Liu X et al. | ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. | 2016 | J. Physiol. Biochem. | pmid:27377933 |
| Egom EE et al. | Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. | 2016 | Mol. Cell. Biochem. | pmid:27372350 |
| Sanagawa A et al. | Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. | 2016 | Mol Med Rep | pmid:27357063 |
| Tiper IV et al. | Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. | 2016 | Pathog Dis | pmid:27354294 |
| Jung M et al. | Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. | 2016 | Sci Signal | pmid:27353364 |
| Rodvold JJ and Zanetti M | Tumor microenvironment on the move and the Aselli connection. | 2016 | Sci Signal | pmid:27353363 |
| Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
| Harijith A et al. | Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27343196 |
| Hernández-Coronado CG et al. | Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. | 2016 | Gen. Comp. Endocrinol. | pmid:27342378 |
| Chakrabarti SS et al. | Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. | 2016 | Curr Alzheimer Res | pmid:27335046 |
| Pierucci F et al. | Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. | 2017 | Arch. Toxicol. | pmid:27318803 |
| Tsai HC and Han MH | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. | 2016 | Drugs | pmid:27318702 |
| Yang Z et al. | TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. | 2016 | Pharmacol. Res. | pmid:27317945 |
| Cantalupo A and Di Lorenzo A | S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27317800 |
| Gharbaran R | Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. | 2016 | Tumour Biol. | pmid:27317256 |
| Juif PE et al. | Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. | 2016 | Expert Opin Drug Metab Toxicol | pmid:27249325 |
| Puli MR et al. | Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. | 2016 | Planta | pmid:27233507 |
| Hollands A et al. | Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. | 2016 | J. Biol. Chem. | pmid:27226531 |
| Mirzaian M et al. | Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. | 2016 | Clin. Chim. Acta | pmid:27221202 |
| Bao XH et al. | [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. | 2016 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:27220580 |
| Marfia G et al. | The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. | 2016 | Stem Cells Dev. | pmid:27217090 |
| Gudipaty SA and Rosenblatt J | Epithelial cell extrusion: Pathways and pathologies. | 2017 | Semin. Cell Dev. Biol. | pmid:27212253 |
| Versmissen J et al. | Familial hypercholesterolaemia: cholesterol efflux and coronary disease. | 2016 | Eur. J. Clin. Invest. | pmid:27208892 |
| Sauvé M et al. | Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. | 2016 | Diabetes | pmid:27207546 |