| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Desai P et al. | Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis. | 2015 | Mol. Cell. Biochem. | pmid:26350564 |
| Nojima H et al. | Sphingolipids in liver injury, repair and regeneration. | 2015 | Biol. Chem. | pmid:25781682 |
| Newton J et al. | Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. | 2015 | Exp. Cell Res. | pmid:25770011 |
| O'Sullivan C and Dev KK | Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling. | 2015 | J. Cell. Sci. | pmid:26359302 |
| Nofer JR | Signal transduction by HDL: agonists, receptors, and signaling cascades. | 2015 | Handb Exp Pharmacol | pmid:25522990 |
| Baranowski M et al. | Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner. | 2015 | Eur. J. Appl. Physiol. | pmid:25519954 |
| Klocke S et al. | Slow-freezing versus vitrification for human ovarian tissue cryopreservation. | 2015 | Arch. Gynecol. Obstet. | pmid:25115279 |
| Burow P et al. | Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophages. | 2015 | Pflugers Arch. | pmid:24965069 |
| Jones EE et al. | Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. | 2015 | Bioanalysis | pmid:26505686 |
| Kim ES et al. | A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. | 2015 | Chem. Biol. Interact. | pmid:25980589 |
| Schaffert SA et al. | mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. | 2015 | J. Immunol. | pmid:26163591 |
| Gao Y et al. | Sphingosine kinase 1 as an anticancer therapeutic target. | 2015 | Drug Des Devel Ther | pmid:26150697 |
| Tian H and Yu Z | Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway. | 2015 | Int J Clin Exp Pathol | pmid:26045781 |
| Trayssac M et al. | Role of Sphingosine-1-Phosphate in Transplant Vasculopathy Evoked by Anti-HLA Antibody. | 2015 | Am. J. Transplant. | pmid:25930666 |
| Pulkoski-Gross MJ et al. | Sphingosine-1-phosphate metabolism: A structural perspective. | 2015 | Crit. Rev. Biochem. Mol. Biol. | pmid:25923252 |
| Ader I et al. | Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer. | 2015 | Oncotarget | pmid:25915662 |
| Rao PV | Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. | 2014 Mar-Apr | J Ocul Pharmacol Ther | pmid:24283588 |
| Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
| Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
| Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
| Anderson G and Maes M | Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. | 2014 | CNS Neurol Disord Drug Targets | pmid:24040808 |
| Kim YI et al. | An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. | 2014 | Mol. Cell. Biol. | pmid:25312644 |
| Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
| Takeshita E et al. | Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24486543 |
| Kamiya T et al. | Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro. | 2014 | Exp. Eye Res. | pmid:24486793 |
| Plano D et al. | Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. | 2014 | J. Med. Chem. | pmid:24471412 |
| Bradley E et al. | Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. | 2014 | PLoS ONE | pmid:25330231 |
| Xu H et al. | Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. | 2014 | Circ. J. | pmid:25319164 |
| Fukui H et al. | S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. | 2014 | Dev. Cell | pmid:25313964 |
| Obinata H et al. | Individual variation of human S1Pâ‚ coding sequence leads to heterogeneity in receptor function and drug interactions. | 2014 | J. Lipid Res. | pmid:25293589 |
| St John AL et al. | S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection. | 2014 | Immunity | pmid:25238098 |
| Davis KM and Isberg RR | Plague's partners in crime. | 2014 | Immunity | pmid:25238090 |
| Bi Y et al. | Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. | 2014 | Am. J. Pathol. | pmid:25111230 |
| Ishitsuka A et al. | FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression. | 2014 | Int. J. Mol. Med. | pmid:25109763 |
| Xiong H et al. | SphK1 confers resistance to apoptosis in gastric cancer cells by downregulating Bim via stimulating Akt/FoxO3a signaling. | 2014 | Oncol. Rep. | pmid:25109605 |
| Zhao X et al. | Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. | 2014 | J. Mol. Cell. Cardiol. | pmid:25106095 |
| Li MH et al. | Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. | 2014 | J. Pediatr. Surg. | pmid:25092091 |
| Tarbell JM et al. | Mechanosensing at the vascular interface. | 2014 | Annu Rev Biomed Eng | pmid:24905872 |
| Potì F et al. | Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). | 2014 | Cardiovasc. Res. | pmid:24891400 |
| Chawla S et al. | Exogenous sphingosine-1-phosphate boosts acclimatization in rats exposed to acute hypobaric hypoxia: assessment of haematological and metabolic effects. | 2014 | PLoS ONE | pmid:24887065 |
| Janes K et al. | The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. | 2014 | J. Biol. Chem. | pmid:24876379 |
| Smyth SS et al. | Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24482375 |
| Takabe K and Spiegel S | Export of sphingosine-1-phosphate and cancer progression. | 2014 | J. Lipid Res. | pmid:24474820 |
| Ishizawa S et al. | Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor. | 2014 | Clin. Exp. Nephrol. | pmid:24463961 |
| Couttas TA et al. | Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis. | 2014 | Acta Neuropathol Commun | pmid:24456642 |
| Gassowska M et al. | Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. | 2014 | Neurochem. Res. | pmid:24452756 |
| Abu El-Asrar AM et al. | Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy. | 2014 | Lipids Health Dis | pmid:25496321 |
| Jensen T et al. | The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25442311 |
| Ye C et al. | Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24633425 |
| Pyszko J and Strosznajder JB | Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. | 2014 | Mol. Neurobiol. | pmid:24399507 |