Wang F and Fishman DA |
Lysophosphatidic acid and invasion. |
2009 |
Cancer Treat. Res. |
pmid:19763441
|
Rohatagi S et al. |
Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator. |
2009 |
J Clin Pharmacol |
pmid:18948412
|
Satoh Y et al. |
Regulation by sphingolipids of the fate of FRTL-5 cells. |
2009 |
J. Biochem. |
pmid:18953023
|
Michaelson LV et al. |
Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. |
2009 |
Plant Physiol. |
pmid:18978071
|
Antoon JW et al. |
Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells. |
2009 |
J. Med. Chem. |
pmid:19694470
|
Zhao J et al. |
Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement. |
2009 |
Cell. Signal. |
pmid:19755153
|
Crousillac S et al. |
Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. |
2009 |
J. Neurophysiol. |
pmid:19776367
|
Igarashi J et al. |
Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells. |
2009 |
Am. J. Physiol., Cell Physiol. |
pmid:19710365
|
Stamer WD et al. |
Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. |
2009 |
Exp. Eye Res. |
pmid:19715693
|
GarcÃa-Pacios M et al. |
Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments. |
2009 |
Biophys. J. |
pmid:19720028
|
Weis N et al. |
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. |
2009 |
Mol. Biol. Cell |
pmid:19129475
|
Li MH et al. |
S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. |
2009 |
Cancer Lett. |
pmid:19131156
|
Gérard A et al. |
The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration. |
2009 |
Blood |
pmid:19139083
|
Berdyshev EV et al. |
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. |
2009 |
J. Biol. Chem. |
pmid:19119142
|
Vogel P et al. |
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. |
2009 |
PLoS ONE |
pmid:19119317
|
Price MM et al. |
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. |
2009 |
FASEB J. |
pmid:19535686
|
Nixon GF |
Sphingolipids in inflammation: pathological implications and potential therapeutic targets. |
2009 |
Br. J. Pharmacol. |
pmid:19563535
|
Taniguchi K et al. |
Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth. |
2009 |
Cancer Sci. |
pmid:19493272
|
Daum G et al. |
Sphingosine 1-phosphate: a regulator of arterial lesions. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19592471
|
Jung ID et al. |
FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration. |
2009 |
Cell. Signal. |
pmid:19632319
|
Martin JL et al. |
Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. |
2009 |
J. Biol. Chem. |
pmid:19633297
|
Knapp M et al. |
Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. |
2009 |
Med. Sci. Monit. |
pmid:19721401
|
Yin H et al. |
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. |
2009 |
J. Biol. Chem. |
pmid:19286662
|
Greenspon J et al. |
Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. |
2009 |
Dig. Dis. Sci. |
pmid:18654850
|
Malemud CJ |
The discovery of novel experimental therapies for inflammatory arthritis. |
2009 |
Mediators Inflamm. |
pmid:20339519
|
Wetter JA et al. |
Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation. |
2009 |
J Biomol Screen |
pmid:19726785
|
Snider AJ et al. |
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. |
2009 |
FASEB J. |
pmid:18815359
|
Zhao M et al. |
[The effects of Sphing-1-phosphate(S1P) on the potassium channel of the ventricular myocytes]. |
2009 |
Zhongguo Ying Yong Sheng Li Xue Za Zhi |
pmid:21186617
|
Sattler K and Levkau B |
Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. |
2009 |
Cardiovasc. Res. |
pmid:19233866
|
Ishii M et al. |
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. |
2009 |
Nature |
pmid:19204730
|
Zhang ZY et al. |
FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis. |
2009 |
Neuropathol. Appl. Neurobiol. |
pmid:19207263
|
Gillies L et al. |
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. |
2009 |
Cell. Signal. |
pmid:19211033
|
Hla T and Im DS |
Cell biology. The ABCs of lipophile transport. |
2009 |
Science |
pmid:19213902
|
Thathiah A et al. |
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. |
2009 |
Science |
pmid:19213921
|
Gaengel K et al. |
Endothelial-mural cell signaling in vascular development and angiogenesis. |
2009 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:19164813
|
Pasquaré SJ et al. |
Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. |
2009 |
Arch. Biochem. Biophys. |
pmid:19691145
|
Xu Y et al. |
Lipid generation and signaling in ovarian cancer. |
2009 |
Cancer Treat. Res. |
pmid:19763440
|
Limaye V |
The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology. |
2008 May-Jun |
Endothelium |
pmid:18568950
|
Vessey DA et al. |
Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. |
2008 Mar-Apr |
J. Biochem. Mol. Toxicol. |
pmid:18418901
|
Won J and Lee GH |
T-cell-targeted signaling inhibitors. |
2008 Jan-Apr |
Int. Rev. Immunol. |
pmid:18300054
|
Liu Q et al. |
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. |
2008 |
Blood |
pmid:17761520
|
Stradner MH et al. |
Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes. |
2008 |
Osteoarthr. Cartil. |
pmid:17703957
|
Wacker BK et al. |
Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. |
2008 |
Biophys. J. |
pmid:17827231
|
Provençal M et al. |
Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. |
2008 |
Thromb. Haemost. |
pmid:18327407
|
Beyer T and Meyer-Hermann M |
Mechanisms of organogenesis of primary lymphoid follicles. |
2008 |
Int. Immunol. |
pmid:18334502
|
Li QF et al. |
Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18423379
|
Wu YP et al. |
Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. |
2008 |
Hum. Mol. Genet. |
pmid:18424450
|
Lavieu G et al. |
Sphingolipids in macroautophagy. |
2008 |
Methods Mol. Biol. |
pmid:18425450
|
Miller AV et al. |
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. |
2008 |
Mol. Cell. Biol. |
pmid:18426913
|
Igarashi J and Michel T |
The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. |
2008 |
Circ. Res. |
pmid:18369161
|
Gohda M et al. |
Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. |
2008 |
J. Immunol. |
pmid:18390715
|
Avery K et al. |
Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells. |
2008 |
Stem Cells Dev. |
pmid:18393631
|
Eskan MA et al. |
TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells. |
2008 |
Eur. J. Immunol. |
pmid:18395849
|
De Luca T et al. |
Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. |
2008 |
Biofactors |
pmid:19734127
|
Krump-Konvalinkova V et al. |
FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18402775
|
Olivera A |
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. |
2008 |
Prostaglandins Other Lipid Mediat. |
pmid:18403224
|
Sefcik LS et al. |
Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. |
2008 |
Biomaterials |
pmid:18405965
|
Arce FT et al. |
Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. |
2008 |
Biophys. J. |
pmid:18408039
|
Goetzl EJ et al. |
Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity. |
2008 |
Biochim. Biophys. Acta |
pmid:18381082
|
Chung FY et al. |
Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. |
2008 |
Arch. Pharm. Res. |
pmid:19023540
|
Osborne N et al. |
The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. |
2008 |
Curr. Biol. |
pmid:19062281
|
Borges S et al. |
Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron. |
2008 |
J. Physiol. (Lond.) |
pmid:18033816
|
Pederson L et al. |
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:19075223
|
Szczepaniak WS et al. |
Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. |
2008 |
Transl Res |
pmid:19010292
|
Kohno T and Igarashi Y |
Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P. |
2008 |
Genes Cells |
pmid:18513330
|
Miron VE et al. |
FTY720 modulates human oligodendrocyte progenitor process extension and survival. |
2008 |
Ann. Neurol. |
pmid:17918267
|
Harvey KA et al. |
Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. |
2008 |
Br. J. Nutr. |
pmid:17925051
|
Takashima S et al. |
G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. |
2008 |
Cardiovasc. Res. |
pmid:18480127
|
Yatomi Y |
Plasma sphingosine 1-phosphate metabolism and analysis. |
2008 |
Biochim. Biophys. Acta |
pmid:17980708
|
Rivera R and Chun J |
Biological effects of lysophospholipids. |
2008 |
Rev. Physiol. Biochem. Pharmacol. |
pmid:18481029
|
Jang S et al. |
Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress. |
2008 |
Neurochem. Res. |
pmid:17940874
|
Bu S et al. |
Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. |
2008 |
J. Biol. Chem. |
pmid:18482992
|
Gavrilovskaya IN et al. |
Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability. |
2008 |
J. Virol. |
pmid:18367532
|
Zanin M et al. |
Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. |
2008 |
Am. J. Physiol., Cell Physiol. |
pmid:17942639
|
Tölle M et al. |
HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. |
2008 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:18483405
|
Huang YT et al. |
Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn. |
2008 |
Cell. Signal. |
pmid:18502612
|
Chen LY et al. |
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. |
2008 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:18502815
|
Wamhoff BR et al. |
Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. |
2008 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:18535287
|
Rapizzi E et al. |
Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. |
2008 |
Mol. Cell. Biochem. |
pmid:18454302
|
Son DJ et al. |
Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. |
2008 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:18571912
|
Peavy RD and Metcalfe DD |
Understanding the mechanisms of anaphylaxis. |
2008 |
Curr Opin Allergy Clin Immunol |
pmid:18596587
|
Cheon S et al. |
Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells. |
2008 |
Biochem. Biophys. Res. Commun. |
pmid:18602364
|
Zhao C et al. |
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha. |
2008 |
J. Lipid Res. |
pmid:18658144
|
Rivera J et al. |
The alliance of sphingosine-1-phosphate and its receptors in immunity. |
2008 |
Nat. Rev. Immunol. |
pmid:18787560
|
Jessup W |
Lipid metabolism: sources and stability of plasma sphingosine-1-phosphate. |
2008 |
Curr. Opin. Lipidol. |
pmid:18769238
|
Rivera J et al. |
New insights on mast cell activation via the high affinity receptor for IgE. |
2008 |
Adv. Immunol. |
pmid:18772004
|
Westerberg LS et al. |
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. |
2008 |
Blood |
pmid:18772454
|
Huang WR et al. |
[SphK-1/S1P signal pathway in CML cells]. |
2008 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:18718048
|
Serrano-Sanchez M et al. |
Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. |
2008 |
Endocrinology |
pmid:18723875
|
Kaya H et al. |
Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? |
2008 |
Fertil. Steril. |
pmid:17517398
|
Ruckhäberle E et al. |
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. |
2008 |
Breast Cancer Res. Treat. |
pmid:18058224
|
Singh IN and Hall ED |
Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury? |
2008 |
J. Neurosci. Res. |
pmid:18058948
|
Stuebe S et al. |
Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. |
2008 |
Naunyn Schmiedebergs Arch. Pharmacol. |
pmid:18046543
|
Ledgerwood LG et al. |
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. |
2008 |
Nat. Immunol. |
pmid:18037890
|
Nussbaumer P et al. |
An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate. |
2008 |
Chem. Phys. Lipids |
pmid:18039471
|
Srinivasan S et al. |
Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. |
2008 |
Diabetes |
pmid:18003758
|
Johann AM et al. |
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. |
2008 |
J. Immunol. |
pmid:18178864
|
Oskeritzian CA et al. |
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. |
2008 |
Blood |
pmid:18178871
|
Oyama O et al. |
The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. |
2008 |
Cardiovasc. Res. |
pmid:18187460
|
Patschan S et al. |
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. |
2008 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:18203850
|