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FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. |
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Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. |
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SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. |
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CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. |
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Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. |
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Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. |
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Cell Transplant |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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PLoS ONE |
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Cell Chem Biol |
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A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. |
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Potential serum biomarkers from a metabolomics study of autism. |
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J Psychiatry Neurosci |
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
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Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
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Oncotarget |
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Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. |
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PLoS ONE |
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. |
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Mediators Inflamm. |
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
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Sci Rep |
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Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. |
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Immunity |
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Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. |
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The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. |
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The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. |
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Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. |
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Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. |
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Oxid Med Cell Longev |
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Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis. |
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Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. |
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Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. |
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Annu. Rev. Physiol. |
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Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
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Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. |
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Biochim. Biophys. Acta |
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Sphingosine-1-phosphate and estrogen signaling in breast cancer. |
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Adv Biol Regul |
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Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. |
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Am. J. Physiol. Heart Circ. Physiol. |
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
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Oncotarget |
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A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. |
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Prog. Lipid Res. |
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Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. |
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Clin. Exp. Pharmacol. Physiol. |
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C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. |
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J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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An oncogenic role for sphingosine kinase 2. |
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Oncotarget |
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Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. |
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Oncotarget |
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Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. |
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J Mammary Gland Biol Neoplasia |
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Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. |
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Sci Rep |
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Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. |
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Pharmacol. Res. |
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Implication of sphingosin-1-phosphate in cardiovascular regulation. |
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Front Biosci (Landmark Ed) |
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. |
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Brain Behav. Immun. |
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Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. |
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Stem Cell Rev |
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Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. |
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Drug Discov. Today |
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Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. |
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Microcirculation |
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Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. |
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Clin. Exp. Pharmacol. Physiol. |
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The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. |
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FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. |
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Endocr. Relat. Cancer |
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IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. |
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Int. Immunol. |
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Resveratrol exerts a biphasic effect on apolipoprotein M. |
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Br. J. Pharmacol. |
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Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. |
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Acta Derm. Venereol. |
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Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. |
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J. Hepatol. |
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Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. |
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Cell Death Differ. |
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