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The Utility of Biomarkers in Osteoporosis Management. |
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The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
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Aging Cell |
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Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
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The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
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Hepatology |
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Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
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Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
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Neurology |
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Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
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Neuropharmacology |
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Nature |
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Stem Cells |
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Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. |
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PLoS ONE |
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Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
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Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
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PLoS ONE |
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. |
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Blood |
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Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? |
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Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. |
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Ann Biomed Eng |
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Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. |
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Respirology |
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Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
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Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. |
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Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. |
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Stroke |
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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
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Neuropharmacology |
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
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Oncotarget |
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The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
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Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. |
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Front Biosci (Landmark Ed) |
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Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
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Biofactors |
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
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Gastroenterology |
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A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
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Cancer |
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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
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Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. |
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Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. |
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The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. |
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Stem Cell Rev |
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The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
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Chemosphere |
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Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
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Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. |
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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. |
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Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
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To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. |
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Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
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Cell Calcium |
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Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. |
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Cell. Signal. |
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Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. |
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Mol. Microbiol. |
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High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
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Mol. Neurobiol. |
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Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. |
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Targeting sphingosine-1-phosphate signaling in lung diseases. |
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Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
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Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
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[Sphingosine kinase-1: role in non alcoholic fatty liver disease]. |
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Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. |
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Bone |
pmid:27612439
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Sphingosine 1-phosphate in metabolic syndrome (Review). |
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Oncotarget |
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