Kimizuka K et al. |
Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels. |
2013 |
Microcirculation |
pmid:22913344
|
Schulz C et al. |
Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease. |
2009 |
Microcirculation |
pmid:19479622
|
Zhang L et al. |
Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. |
2016 |
Microcirculation |
pmid:27015105
|
Markiewicz M et al. |
Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. |
2011 |
Microcirculation |
pmid:21166920
|
Wang L and Dudek SM |
Regulation of vascular permeability by sphingosine 1-phosphate. |
2009 |
Microvasc. Res. |
pmid:18973762
|
Sun X et al. |
Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. |
2009 |
Microvasc. Res. |
pmid:19323978
|
Brown M et al. |
Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. |
2010 |
Microvasc. Res. |
pmid:20053363
|
Wang L et al. |
Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. |
2015 |
Microvasc. Res. |
pmid:25862132
|
Belvitch P and Dudek SM |
Role of FAK in S1P-regulated endothelial permeability. |
2012 |
Microvasc. Res. |
pmid:21925517
|
Tachikawa M et al. |
Lysophospholipids enhance taurine release from rat retinal vascular endothelial cells under hypoosmotic stress. |
2009 |
Microvasc. Res. |
pmid:19804786
|
Belvitch P et al. |
Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. |
2014 |
Microvasc. Res. |
pmid:25072537
|
Garcia JG |
Concepts in microvascular endothelial barrier regulation in health and disease. |
2009 |
Microvasc. Res. |
pmid:19232241
|
Banitalebi E et al. |
The effect of resistance training on plasma S1P level and gene expression of S1P1,2,3 receptors in male Wistar rats. |
2013 |
Minerva Endocrinol. |
pmid:24285107
|
Van Brocklyn JR |
Sphingolipid signaling pathways as potential therapeutic targets in gliomas. |
2007 |
Mini Rev Med Chem |
pmid:17979800
|
Garnero P |
The Utility of Biomarkers in Osteoporosis Management. |
2017 |
Mol Diagn Ther |
pmid:28271451
|
Sanagawa A et al. |
Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. |
2016 |
Mol Med Rep |
pmid:27357063
|
Moon MH et al. |
Activation of S1P2 receptor, a possible mechanism of inhibition of adipogenic differentiation by sphingosine 1‑phosphate. |
2015 |
Mol Med Rep |
pmid:25351259
|
Jeong JK et al. |
Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. |
2015 |
Mol Med Rep |
pmid:26459774
|
Riley RT et al. |
Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. |
2015 |
Mol Nutr Food Res |
pmid:26264677
|
Tsai CH et al. |
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
pmid:28672103
|
Brizuela L et al. |
Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells. |
2014 |
Mol Oncol |
pmid:24768038
|
Wirotanseng LN et al. |
Gq rather than G11 preferentially mediates nociceptor sensitization. |
2013 |
Mol Pain |
pmid:24156378
|
Langeslag M et al. |
Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. |
2014 |
Mol Pain |
pmid:25431213
|
Liu CH et al. |
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. |
1999 |
Mol. Biol. Cell |
pmid:10198065
|
Weis N et al. |
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. |
2009 |
Mol. Biol. Cell |
pmid:19129475
|
Malchinkhuu E et al. |
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. |
2009 |
Mol. Biol. Cell |
pmid:19864456
|
Reinhard NR et al. |
The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
2017 |
Mol. Biol. Cell |
pmid:28954861
|
Dudek SM et al. |
Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. |
2010 |
Mol. Biol. Cell |
pmid:20861316
|
Yamamoto S et al. |
A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
2016 |
Mol. Biol. Cell |
pmid:26631556
|
Weigert A et al. |
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. |
2007 |
Mol. Biol. Cell |
pmid:17652460
|
Squecco R et al. |
Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. |
2006 |
Mol. Biol. Cell |
pmid:16957055
|
Deretic D et al. |
Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors. |
2004 |
Mol. Biol. Cell |
pmid:13679519
|
Hu PF et al. |
Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis. |
2011 |
Mol. Biol. Rep. |
pmid:21116853
|
Fisher KE et al. |
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. |
2006 |
Mol. Cancer |
pmid:17156449
|
Min J et al. |
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. |
2007 |
Mol. Cancer Res. |
pmid:17699106
|
Young N et al. |
Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61. |
2009 |
Mol. Cancer Res. |
pmid:19147534
|
Li MH et al. |
Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. |
2008 |
Mol. Cancer Res. |
pmid:18922980
|
Schneider G et al. |
Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. |
2013 |
Mol. Cancer Res. |
pmid:23615526
|
Langlois S et al. |
Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation. |
2007 |
Mol. Cancer Res. |
pmid:17541067
|
Bryan L et al. |
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. |
2008 |
Mol. Cancer Res. |
pmid:18819934
|
Schnitzer SE et al. |
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. |
2009 |
Mol. Cancer Res. |
pmid:19240180
|
Guillermet-Guibert J et al. |
Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug. |
2009 |
Mol. Cancer Ther. |
pmid:19372554
|
Qin Z et al. |
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. |
2014 |
Mol. Cancer Ther. |
pmid:24140934
|
Dindo D et al. |
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. |
2006 |
Mol. Cancer Ther. |
pmid:16818511
|
Gstalder C et al. |
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
2016 |
Mol. Cancer Ther. |
pmid:27507852
|
Brizuela L et al. |
First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. |
2012 |
Mol. Cancer Ther. |
pmid:22784711
|
Wang D et al. |
S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. |
2008 |
Mol. Cancer Ther. |
pmid:18645009
|
Pchejetski D et al. |
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models. |
2008 |
Mol. Cancer Ther. |
pmid:18644996
|
Annabi B et al. |
Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling. |
2009 |
Mol. Carcinog. |
pmid:19326372
|
Lee MJ et al. |
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. |
2001 |
Mol. Cell |
pmid:11583630
|
Nakahara K et al. |
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. |
2012 |
Mol. Cell |
pmid:22633490
|
Gottlieb D et al. |
The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. |
1999 |
Mol. Cell Biol. Res. Commun. |
pmid:10329480
|
Guo Y et al. |
Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. |
2007 |
Mol. Cell Proteomics |
pmid:17210631
|
Manes NP et al. |
Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. |
2015 |
Mol. Cell Proteomics |
pmid:26199343
|
Desai P et al. |
Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis. |
2015 |
Mol. Cell. Biochem. |
pmid:26350564
|
Liu X et al. |
Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. |
2012 |
Mol. Cell. Biochem. |
pmid:22113622
|
Hashimoto Y et al. |
Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. |
2015 |
Mol. Cell. Biochem. |
pmid:25445169
|
Lu H et al. |
Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. |
2012 |
Mol. Cell. Biochem. |
pmid:22139303
|
Egom EE et al. |
Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. |
2016 |
Mol. Cell. Biochem. |
pmid:27372350
|
Schmitz EI et al. |
Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. |
2012 |
Mol. Cell. Biochem. |
pmid:22899173
|
Rapizzi E et al. |
Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. |
2008 |
Mol. Cell. Biochem. |
pmid:18454302
|
Harvey KA et al. |
Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. |
2010 |
Mol. Cell. Biochem. |
pmid:20401628
|
Furukawa A et al. |
Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds. |
2007 |
Mol. Cell. Biochem. |
pmid:17577630
|
Kohno M et al. |
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. |
2006 |
Mol. Cell. Biol. |
pmid:16980623
|
Miller AV et al. |
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. |
2008 |
Mol. Cell. Biol. |
pmid:18426913
|
Giussani P et al. |
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. |
2006 |
Mol. Cell. Biol. |
pmid:16782891
|
Kim YI et al. |
An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. |
2014 |
Mol. Cell. Biol. |
pmid:25312644
|
Serafimidis I et al. |
G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. |
2011 |
Mol. Cell. Biol. |
pmid:21911471
|
Mizugishi K et al. |
Essential role for sphingosine kinases in neural and vascular development. |
2005 |
Mol. Cell. Biol. |
pmid:16314531
|
Okamoto H et al. |
Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. |
2000 |
Mol. Cell. Biol. |
pmid:11094076
|
Tellier E et al. |
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. |
2007 |
Mol. Cell. Biol. |
pmid:17283058
|
Park K et al. |
A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. |
2013 |
Mol. Cell. Biol. |
pmid:23230267
|
Campos LS et al. |
Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. |
2016 |
Mol. Cell. Biol. |
pmid:26552704
|
Kajimoto T et al. |
Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. |
2007 |
Mol. Cell. Biol. |
pmid:17325039
|
Long JS et al. |
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells. |
2010 |
Mol. Cell. Biol. |
pmid:20516217
|
Kalhori V and Törnquist K |
MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. |
2015 |
Mol. Cell. Endocrinol. |
pmid:25643979
|
Chen C et al. |
Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
2016 |
Mol. Cell. Endocrinol. |
pmid:26948947
|
Lucki NC et al. |
Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. |
2012 |
Mol. Cell. Endocrinol. |
pmid:21864647
|
Björklund S et al. |
Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. |
2005 |
Mol. Cell. Endocrinol. |
pmid:15713536
|
Huang J et al. |
Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. |
2013 |
Mol. Cell. Endocrinol. |
pmid:23127801
|
Takuwa Y et al. |
Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. |
2001 |
Mol. Cell. Endocrinol. |
pmid:11377814
|
Hadizadeh S et al. |
Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. |
2008 |
Mol. Cell. Endocrinol. |
pmid:18191017
|
Ishii T et al. |
The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy. |
2011 |
Mol. Cells |
pmid:21360199
|
Nam JH et al. |
Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. |
2010 |
Mol. Cells |
pmid:20069383
|
Kim YD et al. |
Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. |
2013 |
Mol. Cells |
pmid:23307289
|
Song HJ et al. |
Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. |
2006 |
Mol. Cells |
pmid:16511346
|
Wilson PC et al. |
Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. |
2015 |
Mol. Endocrinol. |
pmid:25871850
|
El-Shewy HM et al. |
Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. |
2012 |
Mol. Endocrinol. |
pmid:22422617
|
Frati A et al. |
Role of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxin. |
2015 |
Mol. Endocrinol. |
pmid:25415609
|
Yagoub D et al. |
Sphingosine kinase 1 isoform-specific interactions in breast cancer. |
2014 |
Mol. Endocrinol. |
pmid:25216046
|
Lan T et al. |
Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. |
2011 |
Mol. Endocrinol. |
pmid:21998146
|
El-Shewy HM et al. |
Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. |
2011 |
Mol. Endocrinol. |
pmid:22016563
|
Brünnert D et al. |
Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. |
2014 |
Mol. Hum. Reprod. |
pmid:24994816
|
Di Pietro M et al. |
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. |
2017 |
Mol. Hum. Reprod. |
pmid:28379469
|
Goyal P et al. |
Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. |
2013 |
Mol. Hum. Reprod. |
pmid:23538947
|
Scotti L et al. |
Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
2016 |
Mol. Hum. Reprod. |
pmid:27645281
|
Schaper K et al. |
Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. |
2014 |
Mol. Immunol. |
pmid:24434636
|
Schröder M et al. |
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. |
2011 |
Mol. Immunol. |
pmid:21435724
|
Ryser MF et al. |
S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. |
2008 |
Mol. Immunol. |
pmid:18760838
|
Jolly PS et al. |
The roles of sphingosine-1-phosphate in asthma. |
2002 |
Mol. Immunol. |
pmid:12217390
|