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Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. |
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Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. |
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Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. |
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Stroke |
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Leukemia |
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Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
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Cell Calcium |
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Cell. Signal. |
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Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. |
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Mol. Microbiol. |
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Targeting sphingosine-1-phosphate signaling in lung diseases. |
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Pharmacol. Ther. |
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Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
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Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. |
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PLoS ONE |
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Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
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Circ. Res. |
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Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
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Mol. Cell. Endocrinol. |
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Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. |
2016 |
Sci Signal |
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Tumor microenvironment on the move and the Aselli connection. |
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Sci Signal |
pmid:27353363
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Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
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Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. |
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Gen. Comp. Endocrinol. |
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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. |
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Curr Alzheimer Res |
pmid:27335046
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Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. |
2016 |
Drugs |
pmid:27318702
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TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. |
2016 |
Pharmacol. Res. |
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S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. |
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J. Pharmacol. Exp. Ther. |
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Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. |
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Expert Opin Drug Metab Toxicol |
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Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. |
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Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. |
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Prog. Lipid Res. |
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. |
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Mediators Inflamm. |
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Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. |
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Arterioscler. Thromb. Vasc. Biol. |
pmid:26966278
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S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. |
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IUBMB Life |
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Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. |
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Platelets |
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Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. |
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Sci Rep |
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Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). |
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Expert Opin Ther Pat |
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Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
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Planta |
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Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. |
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Novel biological markers of bone: from bone metabolism to bone physiology. |
2016 |
Rheumatology (Oxford) |
pmid:26790456
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Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. |
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PLoS ONE |
pmid:26788916
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S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. |
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J. Immunol. |
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Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. |
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Pharmacol. Res. |
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Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. |
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. |
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Biochem. J. |
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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. |
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PLoS ONE |
pmid:26741365
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A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. |
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J. Mol. Graph. Model. |
pmid:26724452
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Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. |
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Oncotarget |
pmid:26716409
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Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. |
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J. Biol. Chem. |
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Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. |
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Mol. Cell. Biol. |
pmid:26552704
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DNA damage response and sphingolipid signaling in liver diseases. |
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Surg. Today |
pmid:26514817
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Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. |
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Cell. Signal. |
pmid:26994820
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Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. |
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Exp. Biol. Med. (Maywood) |
pmid:26376826
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Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
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